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Announces ABBV-951 (Foslevodopa\/Foscarbidopa) Showed Improvement in Controlling Motor Fluctuations Compared to Oral Levodopa\/Carbidopa Medication in Pivotal Phase 3 Trial in Patients with Advanced Parkinson's Disease","therapeuticArea":"Neurology","highestDevelopmentStatus":"Phase III","country":"","productType":"Small molecule","productStatus":"Approved","date":"October 2021","year":"2021","type":"Not Applicable","leadProduct":"Etilevodopa","moa":"D3 receptor","url1":"","url2":"","graph1":"Neurology","graph2":"Phase III","graph3":"AbbVie Inc","amount2":0,"therapeuticAreaNew":"Neurology","highestDevelopmentStatusNew":"Phase III","highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","productSubType":"","amount2New":0,"dosageForm":"Subcutaneous Infusion","sponsorNew":"AbbVie Inc \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"AbbVie Inc.."},{"orgOrder":0,"company":"Intrance Medical System","sponsor":"Erik 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.."},{"orgOrder":0,"company":"Amneal Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Amneal Announces Submission of New Drug Application to the U.S. FDA for IPX203 for the Treatment of Parkinson\u2019s Disease","therapeuticArea":"Neurology","highestDevelopmentStatus":"Phase III","country":"","productType":"Small molecule","productStatus":"New Molecular Entity","date":"August 2022","year":"2022","type":"Not Applicable","leadProduct":"Etilevodopa","moa":"D3 receptor","url1":"","url2":"","graph1":"Neurology","graph2":"Phase III","graph3":"Amneal Pharmaceuticals","amount2":0,"therapeuticAreaNew":"Neurology","highestDevelopmentStatusNew":"Phase III","highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","productSubType":"","amount2New":0,"dosageForm":"Capsule, Extended Release","sponsorNew":"Amneal Pharmaceuticals \/ Not 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                          01

                          Details : ABBV-951 (Foslevodopa/Foscarbidopa) is a solution of levodopa and carbidopa prodrugs for continuous subcutaneous infusion that is being investigated for the treatment of advanced Parkinson's disease in patients whose motor symptoms are not controlled by ...

                          Brand Name : ABBV-951

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 28, 2021

                          Lead Product(s) : Etilevodopa,Carbidopa

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

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                          Details : Crexont (carbidopa/levodopa) is a novel, oral extended-release capsule formulation. It is indicated for the treatment of parkinson's disease with motor fluctuations.

                          Brand Name : Crexont

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 07, 2024

                          Lead Product(s) : Carbidopa,Etilevodopa

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

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                          Details : Through the licensing agreement, Zambon will commercialize IPX203, an oral formulation of carbidopa/levodopa extended-release capsules designed for the treatment of Parkinson’s disease.

                          Brand Name : IPX203

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 27, 2024

                          Lead Product(s) : Carbidopa,Etilevodopa

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Zambon Group SpA

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          04

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                          Details : IPX203 (carbidopa/levodopa) is a novel, oral extended-release capsule formulation. It is being evaluated in phase 3 clinical trials for the treatment of parkinson's disease with motor fluctuations.

                          Brand Name : IPX203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 08, 2024

                          Lead Product(s) : Carbidopa,Etilevodopa

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

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                          Details : EVX-101 is a novel, proprietary, gastro-retentive, sustained-release tablet formulation of 5-hydroxytryptophan (5-HTP), which is investigated for the treatment of major depressive disorder.

                          Brand Name : EVX-101

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 02, 2023

                          Lead Product(s) : HSDB 4295,Carbidopa

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

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                          Details : EVX-101 is a novel, proprietary, gastro-retentive, sustained-release tablet formulation of 5-hydroxytryptophan (5-HTP), which is investigated for the treatment of major depressive disorder.

                          Brand Name : EVX-101

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 21, 2023

                          Lead Product(s) : HSDB 4295,Carbidopa

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase I

                          Sponsor : Quotient Sciences

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

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                          Details : ND0612 is an investigative drug-device combination therapy – a 24 hours/day, continuous subcutaneous infusion of liquid levodopa/carbidopa (LD/CD) for people with Parkinson’s disease (PD) experiencing motor fluctuations.

                          Brand Name : ND0612

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 28, 2023

                          Lead Product(s) : Etilevodopa,Carbidopa

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : NeuroDerm

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

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                          Details : IPX203 is a novel, oral formulation of contains immediate-release granules and extended-release capsules designed for the treatment of Parkinson’s disease.

                          Brand Name : IPX203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 03, 2023

                          Lead Product(s) : Carbidopa,Etilevodopa

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

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                          Details : EVX-101 is a proprietary, oral tablet, gastroretentive, slow-release formulation of 5-HTP and low-dose carbidopa. It is being developed for patients with depression responding inadequately to first-line SSRI/SNRI antidepressants monotherapy.

                          Brand Name : EVX-101

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 28, 2023

                          Lead Product(s) : HSDB 4295,Carbidopa

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

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                          Details : Through the acquisition, Navamedic will broaden its product portfolio, including Flexilev, containing two active substances, levodopa and carbidopa and to support patients suffering from medical conditions, such as Parkinson's disease.

                          Brand Name : Flexilev

                          Molecule Type : Small molecule

                          Upfront Cash : $9.3 million

                          April 24, 2023

                          Lead Product(s) : Etilevodopa,Carbidopa

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Navamedic

                          Deal Size : $9.3 million

                          Deal Type : Acquisition

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