Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : TCR Therapy
Therapeutic Area : Oncology
Study Phase : Discovery
Sponsor : AstraZeneca
Deal Size : $320.0 million
Deal Type : Acquisition
AstraZeneca To Acquire Neogene Therapeutics, Accelerating Ambition in Oncology Cell Therapy
Details : With a shared goal of bringing cell therapies to patients with solid tumours, Neogene’s expertise in TCR-T discovery, development and manufacturing will strengthen AstraZeneca’s ambition to transform outcomes for patients.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : $200.0 million
November 29, 2022
Lead Product(s) : TCR Therapy
Therapeutic Area : Oncology
Highest Development Status : Discovery
Sponsor : AstraZeneca
Deal Size : $320.0 million
Deal Type : Acquisition
Lead Product(s) : NT-125
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : NT-125, designed to contain up to five distinct neoantigen-specific TCRs per patient in single cell product of highly functional engineered T cells, allowing multiple neoantigens by HLA molecules targeted with goal to create a more impactful TCR therapy ...
Brand Name : NT-125
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
May 10, 2022
Lead Product(s) : NT-125
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : TCR-based Therapy
Therapeutic Area : Oncology
Study Phase : Discovery
Sponsor : AstraZeneca
Deal Size : $320.0 million
Deal Type : Acquisition
Acquisition of Neogene Therapeutics Completed
Details : Acquisition will provide access to next-generation T-cell receptor therapies with promising potential for targeting solid tumours to AstraZeneca. TCR-based Therapies can recognise intracellular targets, including cancer-specific mutations.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : $320.0 million
January 16, 2022
Lead Product(s) : TCR-based Therapy
Therapeutic Area : Oncology
Highest Development Status : Discovery
Sponsor : AstraZeneca
Deal Size : $320.0 million
Deal Type : Acquisition
Lead Product(s) : CAR-T cell therapy
Therapeutic Area : Oncology
Study Phase : Discovery
Recipient : Twist Bioscience
Deal Size : Undisclosed
Deal Type : Partnership
Details : The companies will leverage Neogene’s expertise in targeting tumor neo-antigens, mutated proteins found in cancer cells together with Twist’s DNA synthesis platform and product lines to develop personalized CAR) T cell therapies and TCR therapies for...
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
October 13, 2020
Lead Product(s) : CAR-T cell therapy
Therapeutic Area : Oncology
Highest Development Status : Discovery
Recipient : Twist Bioscience
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Neo-Antigen T Cell Receptor
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : EcoR1 Capital
Deal Size : $110.0 million
Deal Type : Series A Financing
Details : Neogene’s proprietary technology platform identifies specific T cell receptor (TCR) genes from routine tumor samples using state-of-the-art synthetic biology tools.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
September 14, 2020
Lead Product(s) : Neo-Antigen T Cell Receptor
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : EcoR1 Capital
Deal Size : $110.0 million
Deal Type : Series A Financing
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