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Find Clinical Drug Development Pipelines & Deals | PipelineProspector
ADI-001 is a first-in-class allogeneic gamma delta (γδ) CAR T cell therapy, which is being developed for the treatment of pattients with lupus nephritis.
The collaboration aims to lever a large body of genetic data on patients living with chronic kidney disease, to further support the clinical advancement of Walden’s WAL0921, an anti-suPAR antibody.
WAL0921 is the first in class, proprietary, humanized monoclonal antibody that binds soluble urokinase plasminogen activator receptor, inhibiting the pro-inflammatory action that causes podocyte dysfunction and renal disease.
EQ001 (itolizumab) is a first-in-class anti-CD6 monoclonal antibody that selectively targets the CD6-ALCAM signaling pathway to selectively downregulate pathogenic T effector cells. It is being evaluated for the treatment of Lupus Nephritis.
VAR 200 (2-hydroxypropyl-beta-cyclodextrin) is being developed to mediate removal of excess cholesterol that damages the kidneys’ filtration system (renal glomeruli podocytes) in patients with Diabetic Kidney Disease.
Cilastatin is an enzymatic dipeptidase-1 (DPEP-1) inhibitor, small molecule drug. It is being evaluated for the treatment of toxin related acute kidney injury.
AlloNK (AB-101) is an allogeneic NK cell therapy candidate designed to enhance the antibody-dependent cellular cytotoxicity effect of monoclonal antibodies or NK cell engagers. in combination with rituximab or obinutuzumab for the treatment of lupus nephritis.
DISC-0974 is an investigational monoclonal antibody targeting a BMP-signaling co-receptor called hemojuvelin (HJV). It is being developed for the treatment of anemia in non-dialysis dependent chronic kidney disease.
Auxora (zegocractin) is a potent and selective small molecule inhibitor of Orai1-containing CRAC channels, to be evaluated in a Phase 2 trial in acute kidney injury (AKI) with associated acute hypoxemic respiratory failure (AHRF).
Under the collaboration, Walden and U-M will analyze the effect in plasma of reducing suPAR levels seen in Walden’s single ascending dose study of WAL0921, first-in-class, proprietary, humanized monoclonal antibody that binds suPAR, in healthy subjects.