Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-8a-(2-propenyl)-, (8aR)-
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Neuren Phase 2 trial shows significant improvements in Pitt Hopkins syndrome
Details : Neuren lead product candidate NNZ-2591 is being evaluated in the mid-stage clinical trial studies for the treatment of patients suffering from Pitt Hopkins syndrome.
Brand Name : NNZ-2591
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 27, 2024
Lead Product(s) : Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-8a-(2-propenyl)-, (8aR)-
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cyclo-Glycyl-proline Analog
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Acadia Pharmaceuticals
Deal Size : $463.0 million
Deal Type : Licensing Agreement
Details : Under the agreement, Acadia will acquire ex-North American rights to the drug as well as global rights in Rett syndrome and Fragile X syndrome to Neuren’s development candidate NNZ-2591, an investigational synthetic analogue of cGP, for Rett syndrome a...
Brand Name : NNZ-2591
Molecule Type : Small molecule
Upfront Cash : $100.0 million
July 13, 2023
Lead Product(s) : Cyclo-Glycyl-proline Analog
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Acadia Pharmaceuticals
Deal Size : $463.0 million
Deal Type : Licensing Agreement
Lead Product(s) : Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-8a-(2-propenyl)-, (8aR)-
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Positive FDA Meetings Enable Neuren to Proceed with INDs for Three Phase 2 Trials
Details : NNZ-2591 has ideal attributes – a unique mechanism of action, consistent and compelling results in the model of each disorder, a clearly identified optimum dose and proprietary manufacturing with high purity and yield.
Brand Name : NNZ-2591
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 01, 2021
Lead Product(s) : Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-8a-(2-propenyl)-, (8aR)-
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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