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Find Clinical Drug Pipeline Developments & Deals by Neurocrine Biosciences
NBI-1076986 is an investigational, oral, M4 subtype-selective muscarinic acetylcholine receptor antagonist for the potential treatment of movement disorders.
NBI-1117567 is an investigational, oral, M1/M4 (M1 preferring) selective muscarinic agonist being investigated as a potential treatment of neurological and neuropsychiatric conditions.
Ingrezza (valbenazine) a new sprinkle formulation of capsules which is selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved by the U.S. FDA for the treatment adults with tardive dyskinesia and chorea associated with Huntington's disease (HD).
TAK-653 (NBI-1065845) is an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) positive allosteric modulator. It is being evaluated for the treatment of adults with major depressive disorder.
The collaboration will continue to leverage Sentia’s peptide-based platform and Neurocrine’s drug development expertise in CRF biology to discover novel, long-acting corticotropin-releasing factor receptor antagonist peptide therapeutics to address HPA-driven diseases.
Through the collaboration, Neurocrine Biosciences has selected a lead development candidate in the GBA1 gene therapy program for the potential treatment of Parkinson’s disease and other GBA1-mediated diseases.
Under the licensing agreement, Neurocrine gains development and commercialization rights to a broad portfolio of novel clinical and preclinical subtype-selective muscarinic M4 receptor agonists, NBI-1117568 for the treatment of Schizophrenia.
NBI-1070770 is a novel, selective, and orally active, negative allosteric modulator (NAM) of the NR2B subunit-containing N-methyl-D-aspartate (NMDA NR2B) receptor. It is being evaluated for the treatment of adults with major depressive disorder.
NBI-1065890 is an investigational, oral, selective inhibitor of the vesicular monoamine transporter-2 (VMAT2), which is being evaluated for the potential treatment of certain neurological and neuropsychiatric conditions.
Through collabraotion, Neurocrine will to focus on the development and commercialization of VY-FXN01, which helps to restore FXN protein levels. It is being evaluated in the treatment of Friedreich’s ataxia.
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