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                          Details : NBI-1140675 is an investigational, oral, selective second-generation small molecule inhibitor of VMAT2. It is being evaluated for the treatment of neurological and neuropsychiatric conditions.

                          Product Name : NBI-1140675

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 05, 2025

                          Lead Product(s) : NBI-1140675

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Ingrezza (valbenazine) is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved by the U.S. FDA for the treatment adults with tardive dyskinesia.

                          Product Name : Ingrezza

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 27, 2025

                          Lead Product(s) : Valbenazine Tosylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : NBI-1065845 (osavampator) is an investigational AMPA positive allosteric modulator. It is being evaluated for the treatment of adults with major depressive disorder.

                          Product Name : NBI-1065845

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 28, 2025

                          Lead Product(s) : Osavampator

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Crenessity (crinecerfont) is a corticotropin-releasing factor type 1 receptor antagonist. It is indicated for the treatment of congenital adrenal hyperplasia.

                          Product Name : NBI-74788

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 13, 2024

                          Lead Product(s) : Crinecerfont

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Luvadaxistat (NBI-1065844) is an investigational, oral, selective inhibitor with a high binding affinity to d-amino acid oxidase (DAAO), being investigated for schizophrenia.

                          Product Name : NBI-1065844

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 09, 2024

                          Lead Product(s) : Luvadaxistat

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : NBI-1076986 is an investigational, oral, M4 subtype-selective muscarinic acetylcholine receptor antagonist for the potential treatment of movement disorders.

                          Product Name : NBI-1076986

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 05, 2024

                          Lead Product(s) : NBI-1076986

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : NBI-1117568 is an investigational, muscarinic M4 selective acetylcholine receptor agonist investigated for the treatment of schizophrenia.

                          Product Name : NBI-1117568

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 28, 2024

                          Lead Product(s) : NBI-1117568

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : NBI-1117567 is an investigational, oral, M1/M4 (M1 preferring) selective muscarinic agonist being investigated as a potential treatment of neurological and neuropsychiatric conditions.

                          Product Name : NBI-1117567

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 05, 2024

                          Lead Product(s) : NBI-1117567

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Ingrezza (valbenazine), a new sprinkle formulation of capsules, a selective VMAT2 inhibitor approved by USFDA for treating adults with tardive dyskinesia & chorea associated with Huntington's disease.

                          Product Name : Ingrezza

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 30, 2024

                          Lead Product(s) : Valbenazine Tosylate

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          10

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : TAK-653 (NBI-1065845) is an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid PAM, currently under investigation for major depressive disorder in adults.

                          Product Name : TAK-653

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 23, 2024

                          Lead Product(s) : NBI-1065845

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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