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Therapeutics","amount2":0.20000000000000001,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.20000000000000001,"dosageForm":"","sponsorNew":"Tenvie Therapeutics \/ ARCH Venture Partners","highestDevelopmentStatusID":"5","companyTruncated":"Tenvie Therapeutics \/ ARCH Venture Partners"},{"orgOrder":0,"company":"Pheno Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"PTD802","moa":"GPR17","graph1":"Neurology","graph2":"IND Enabling","graph3":"Pheno Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"Pheno Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Pheno Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"TheraVac","sponsor":"Perceiv AI","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Vaccine","year":"2025","type":"Partnership","leadProduct":"TV-301","moa":"","graph1":"Neurology","graph2":"IND Enabling","graph3":"TheraVac","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"TheraVac \/ Perceiv AI","highestDevelopmentStatusID":"5","companyTruncated":"TheraVac \/ Perceiv AI"},{"orgOrder":0,"company":"Virpax Pharmaceuticals","sponsor":"Spartan Capital Securities","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Public Offering","leadProduct":"Enkephalin","moa":"Delta opioid receptor","graph1":"Neurology","graph2":"IND Enabling","graph3":"Virpax Pharmaceuticals","amount2":0.01,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.01,"dosageForm":"Nasal Spray","sponsorNew":"Virpax Pharmaceuticals \/ Spartan Capital Securities","highestDevelopmentStatusID":"5","companyTruncated":"Virpax Pharmaceuticals \/ Spartan Capital Securities"},{"orgOrder":0,"company":"Virpax Pharmaceuticals","sponsor":"Spartan Capital Securities","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Public Offering","leadProduct":"Enkephalin","moa":"Delta opioid receptor","graph1":"Neurology","graph2":"IND Enabling","graph3":"Virpax Pharmaceuticals","amount2":0.01,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.01,"dosageForm":"Nasal Spray","sponsorNew":"Virpax Pharmaceuticals \/ Spartan Capital Securities","highestDevelopmentStatusID":"5","companyTruncated":"Virpax Pharmaceuticals \/ Spartan Capital Securities"},{"orgOrder":0,"company":"Serina Therapeutics","sponsor":"JuvVentures","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Controlled Substance","year":"2025","type":"Financing","leadProduct":"POZ-apomorphine","moa":"Dopamine receptor","graph1":"Neurology","graph2":"IND Enabling","graph3":"Serina Therapeutics","amount2":0.01,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.01,"dosageForm":"Subcutaneous Injection","sponsorNew":"Serina Therapeutics \/ JuvVentures","highestDevelopmentStatusID":"5","companyTruncated":"Serina Therapeutics \/ JuvVentures"},{"orgOrder":0,"company":"NKGen Biotech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"Troculeucel","moa":"Undisclosed","graph1":"Neurology","graph2":"IND Enabling","graph3":"NKGen Biotech","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"NKGen Biotech \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"NKGen Biotech \/ Inapplicable"},{"orgOrder":0,"company":"Mira Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Ketamine Analog","moa":"NMDA receptor","graph1":"Neurology","graph2":"IND Enabling","graph3":"Mira Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Mira Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Mira Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"CAMP4 Therapeutics","sponsor":"5AM Ventures","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Financing","leadProduct":"Undisclosed","moa":"CIDEB","graph1":"Neurology","graph2":"IND Enabling","graph3":"CAMP4 Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"CAMP4 Therapeutics \/ 5AM Ventures","highestDevelopmentStatusID":"5","companyTruncated":"CAMP4 Therapeutics \/ 5AM Ventures"},{"orgOrder":0,"company":"Atalanta Therapeutics","sponsor":"EQT Life Sciences","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2025","type":"Series B Financing","leadProduct":"ATL-201","moa":"KCNT1","graph1":"Neurology","graph2":"IND Enabling","graph3":"Atalanta Therapeutics","amount2":0.080000000000000002,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.10000000000000001,"dosageForm":"Undisclosed","sponsorNew":"Atalanta Therapeutics \/ EQT Life Sciences","highestDevelopmentStatusID":"5","companyTruncated":"Atalanta Therapeutics \/ EQT Life Sciences"},{"orgOrder":0,"company":"Atalanta Therapeutics","sponsor":"EQT Life Sciences","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2025","type":"Series B Financing","leadProduct":"ATL-201","moa":"KCNT1","graph1":"Neurology","graph2":"IND Enabling","graph3":"Atalanta Therapeutics","amount2":0.10000000000000001,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.10000000000000001,"dosageForm":"Undisclosed","sponsorNew":"Atalanta Therapeutics \/ EQT Life Sciences","highestDevelopmentStatusID":"5","companyTruncated":"Atalanta Therapeutics \/ EQT Life Sciences"},{"orgOrder":0,"company":"CAMP4 Therapeutics","sponsor":"Patient Square Capital","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Series B Financing","leadProduct":"Undisclosed","moa":"CIDEB","graph1":"Neurology","graph2":"IND Enabling","graph3":"CAMP4 Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"CAMP4 Therapeutics \/ Patient Square Capital","highestDevelopmentStatusID":"5","companyTruncated":"CAMP4 Therapeutics \/ Patient Square Capital"},{"orgOrder":0,"company":"Praxis Bioresearch","sponsor":"Invitae","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"PRAX-222","moa":"SCN2A","graph1":"Neurology","graph2":"IND Enabling","graph3":"Praxis Bioresearch","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Praxis Bioresearch \/ Invitae","highestDevelopmentStatusID":"5","companyTruncated":"Praxis Bioresearch \/ Invitae"},{"orgOrder":0,"company":"Magenta Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Antibody-drug Conjugate","year":"2020","type":"Inapplicable","leadProduct":"CD45-ADC","moa":"CD45","graph1":"Neurology","graph2":"IND Enabling","graph3":"Magenta Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Magenta Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Magenta Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Praxis Precision Medicines","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"PRAX-222","moa":"SCN2A","graph1":"Neurology","graph2":"IND Enabling","graph3":"Praxis Precision Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Praxis Precision Medicines \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Praxis Precision Medicines \/ Inapplicable"},{"orgOrder":0,"company":"Praxis Precision Medicines","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"PRAX-222","moa":"SCN2A","graph1":"Neurology","graph2":"IND Enabling","graph3":"Praxis Precision Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Praxis Precision Medicines \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Praxis Precision Medicines \/ Inapplicable"},{"orgOrder":0,"company":"Praxis Precision Medicines","sponsor":"Ionis Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Inapplicable","leadProduct":"PRAX-222","moa":"SCN2A","graph1":"Neurology","graph2":"IND Enabling","graph3":"Praxis Precision Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Praxis Precision Medicines \/ Ionis Pharmaceuticals","highestDevelopmentStatusID":"5","companyTruncated":"Praxis Precision Medicines \/ Ionis Pharmaceuticals"},{"orgOrder":0,"company":"Suven Pharmaceuticals","sponsor":"Right Brain Bio","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"INDIA","productType":"Undisclosed","year":"2025","type":"Agreement","leadProduct":"RB-190","moa":"Dopamine","graph1":"Neurology","graph2":"IND Enabling","graph3":"Suven Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Suven Pharmaceuticals \/ Right Brain Bio","highestDevelopmentStatusID":"5","companyTruncated":"Suven Pharmaceuticals \/ Right Brain Bio"}]

Find FDA Investigational New Drug (IND) Submissions for Neurology

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : FZ008-145

                          Therapeutic Area : Neurology

                          Study Phase : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : FZ008-145 is a highly selective second-generation Nav1.8 inhibitor, offering powerful, non-addictive pain relief advantages. It is being evaluated in preclinical studies for acute and chronic pain.

                          Product Name : FZ008-145

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 10, 2024

                          Lead Product(s) : FZ008-145

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : The agreement aims for the production of its lead drug candidate, RB-190, targeting the root cause of Parkinson's disease.

                          Product Name : RB-190

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          March 11, 2025

                          Lead Product(s) : RB-190

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Right Brain Bio

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          03

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : Ketamir-2 (ketamine analog), a novel oral, NMDA receptor inhibitor which is being evaluated for the treatment of patients suffering from neuropathic pain.

                          Product Name : Ketamir-2

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 04, 2025

                          Lead Product(s) : Ketamine Analog

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : SNK01 (troculeucel) is an autologous, non-genetically modified NK cell product that has enhanced cytotoxicity and activating receptor expression, being investigated for frontotemporal dementia.

                          Product Name : SNK01

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 21, 2025

                          Lead Product(s) : Troculeucel

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : The proceeds from the finacing will help the company to advance it's IND stage product SER-252 (POZ-apomorphine) for the treatment of Parkinson's disease.

                          Product Name : SER-252

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          February 03, 2025

                          Lead Product(s) : POZ-apomorphine

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : JuvVentures

                          Deal Size : $10.0 million

                          Deal Type : Financing

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                          06

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : The net proceeds will used to fund the clinical development of Envelta (enkephalin), which is being evaluated for the treatment of neoplasms.

                          Product Name : Envelta

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 30, 2025

                          Lead Product(s) : Enkephalin

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Spartan Capital Securities

                          Deal Size : $6.0 million

                          Deal Type : Public Offering

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                          07

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : The proceeds will support Phase 1 clinical trials of the company's investigational RNAi therapies, including ATL-201 for KCNT1-related epilepsy and ATL-101 for Huntington's disease.

                          Product Name : ATL-201

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          January 28, 2025

                          Lead Product(s) : ATL-201

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : EQT Life Sciences

                          Deal Size : $75.0 million

                          Deal Type : Series B Financing

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                          08

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : The financing aims to support clinical development of the company’s investigational RNAi therapy ATL-201 for treatment of KCNT1-related epilepsy.

                          Product Name : ATL-201

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          January 28, 2025

                          Lead Product(s) : ATL-201

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : EQT Life Sciences

                          Deal Size : $97.0 million

                          Deal Type : Series B Financing

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                          09

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : PTD802 is a novel small molecule therapeutic designed to promote remyelination by inhibiting GPR17. It is being investigated for multiple sclerosis.

                          Product Name : PTD802

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 14, 2025

                          Lead Product(s) : PTD802

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          DCAT Week
                          Not Confirmed
                          DCAT Week
                          Not Confirmed

                          Details : The partnership will allow TheraVac to increase the likelihood of success of the clinical trial of its lead candidate vaccine, TV-301, for patients with mild cognitive impairment.

                          Product Name : TV-301

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          January 13, 2025

                          Lead Product(s) : TV-301

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Perceiv AI

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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