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Prodrug","moa":"","graph1":"Neurology","graph2":"Phase II","graph3":"Ensysce Biosciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"Ensysce Biosciences \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Ensysce Biosciences \/ Undisclosed"},{"orgOrder":0,"company":"Alector","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"AL002","moa":"","graph1":"Neurology","graph2":"Phase II","graph3":"Alector","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"Alector \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Alector \/ Not Applicable"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Frexalimab

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : SAR441344 (frexalimab) is a novel monoclonal antibody that is thought to block the costimulatory CD40/CD40L and investigational product relapsing multiple sclerosis.

                          Brand Name : SAR441344

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 31, 2023

                          Lead Product(s) : Frexalimab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Lead Product(s) : Bupivacaine

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : Allay Therapeutics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : ATX-101 is a small product placed directly into the TKA surgical site in a simple, ‘place & go’ manner designed to add minimal extra complexity and time to the procedure.

                          Brand Name : ATX-101

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 13, 2022

                          Lead Product(s) : Bupivacaine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Allay Therapeutics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Evonik company banner

                          03

                          Lead Product(s) : Medical Cannabis Product

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : MediCane Health

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Details : As part of a collaboration between Dr. Reddy's and MediCane that started in 2021, MediCane will supply the medical cannabis products to Dr. Reddy's from its EU-GMP-certified facilities in Portugal along with providing logistical and regulatory support.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          April 01, 2022

                          Lead Product(s) : Medical Cannabis Product

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : MediCane Health

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Dr Reddy Company Banner

                          04

                          Lead Product(s) : ENT-01

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : Enterin

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Details : Enterin completed the first human clinical trials for ENT-01 which demonstrated that oral administration of its treatment has restored function of the nervous system of the gastrointestinal tract in Parkinson’s patients.

                          Brand Name : ENT-01

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 28, 2022

                          Lead Product(s) : ENT-01

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Enterin

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Pfizer centreOne

                          05

                          Lead Product(s) : Simufilam

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : Cassava Sciences

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Details : Evonik to supply commercial quantities of simufilam, a drug candidate for the treatment of Alzheimer’s disease. Simufilam is a novel drug, discovered at Cassava Sciences, that targets both neuroinflammation and neurodegeneration.

                          Brand Name : PTI-125

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 09, 2021

                          Lead Product(s) : Simufilam

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Cassava Sciences

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Evonik company banner

                          06

                          Lead Product(s) : Tolebrutinib

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Study’s primary endpoint was met, demonstrating that the BTK inhibitor significantly reduced disease activity associated with multiple sclerosis (MS) as measured by magnetic resonance imaging.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 17, 2020

                          Lead Product(s) : Tolebrutinib

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          07

                          Lead Product(s) : Tolebrutinib

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Sanofi’s BTK inhibitor will be first disease-modifying therapy to address sources of multiple sclerosis damage in the brain.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 06, 2020

                          Lead Product(s) : Tolebrutinib

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          08

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : The net proceeds will be used to fund the clinical advancement of the company's lead product BMB-101, which is being evaluated for the treatment of Epilepsy. "

                          Brand Name : BMB-101

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          November 04, 2024

                          Lead Product(s) : BMB-101

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Asset Management

                          Deal Size : $35.0 million

                          Deal Type : Private Placement

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                          09

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : The proceeds will advance company's Phase 2a clinical trial for the intranasal delivery of TZLS-401 (foralumab) in patients with non-active secondary progressive multiple sclerosis.

                          Brand Name : TZLS-401

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 30, 2024

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Titan Partners Group

                          Deal Size : $10.0 million

                          Deal Type : Public Offering

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                          10

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : NOE-105(gemlapodect) is a potential first-in-class phosphodiesterase-10A (PDE10A) inhibitor in mid-stage clinical development as a dopamine modulator for Tourette syndrome.

                          Brand Name : NOE-105

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 30, 2024

                          Lead Product(s) : Gemlapodect

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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