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                            Deal Type : Inapplicable

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                            First ALS Patient Enrolled in NIH-Funded EAP Trial of MN-166

                            Details : MN-166 (ibudilast) is a small molecule compound that inhibits PDE4 and inflammatory cytokines, including MIF. It is being developed for ALS.

                            Product Name : MN-166

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 08, 2025

                            Lead Product(s) : Ibudilast

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Anavex Life Sciences

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                            Not Confirmed

                            Anavex Life Sciences

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                            Not Confirmed
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                            Lead Product(s) : Blarcamesine

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Anavex Reports Positive Long-Term Data From Alzheimer’s Trial

                            Details : ANAVEX2-73 (blarcamesine) is an oral drug that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors. It is under phase 2/3 clinical development for treating Alzheimer's disease.

                            Product Name : ANAVEX2-73

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 05, 2025

                            Lead Product(s) : Blarcamesine

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Acumen Pharmaceuticals

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                            Not Confirmed

                            Acumen Pharmaceuticals

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                            Lead Product(s) : Sabirnetug

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Acumen Completes ALTITUDE-AD Phase 2 Enrollment for Sabirnetug in Alzheimer’s

                            Details : ACU193 (sabirnetug) is a humanized monoclonal antibody (mAb), it selectively targets toxic soluble AβOs which is the primary underlying cause of the neurodegenerative process in alzheimer’s disease.

                            Product Name : ACU193

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 26, 2025

                            Lead Product(s) : Sabirnetug

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Acumen Pharmaceuticals

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                            WRIB
                            Not Confirmed

                            Acumen Pharmaceuticals

                            U.S.A arrow
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                            Not Confirmed
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                            Lead Product(s) : Sabirnetug,Hyaluronidase Enzyme

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Acumen Reports Phase 1 Data for Subcutaneous Sabirnetug in Healthy Volunteers

                            Details : ACU193 (sabirnetug) is a humanized monoclonal antibody (mAb), it selectively targets toxic soluble AβOs which is the primary underlying cause of the neurodegenerative process in alzheimer’s disease.

                            Product Name : ACU193

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 19, 2025

                            Lead Product(s) : Sabirnetug,Hyaluronidase Enzyme

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            PharmaTher

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                            Not Confirmed

                            PharmaTher

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                            Not Confirmed
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                            Lead Product(s) : Ketamine Hydrochloride

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            PharmaTher Receives US FDA Approval Goal Date for Ketamine

                            Details : Ketarx (ketamine) is a NMDA receptor antagonist, which is being evaluated as a potential treatment for mental health, and neurological disorders like parkinsons.

                            Product Name : Ketarx

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            March 11, 2025

                            Lead Product(s) : Ketamine Hydrochloride

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            PharmaTher

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                            WRIB
                            Not Confirmed

                            PharmaTher

                            Canada arrow
                            WRIB
                            Not Confirmed
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                            Lead Product(s) : Ketamine Hydrochloride

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            PharmaTher Provides Update on FDA New Drug Application for Ketamine

                            Details : Ketarx (ketamine) is a NMDA receptor antagonist, which is being evaluated as a potential treatment for mental health, and neurological disorders like parkinsons.

                            Product Name : Ketarx

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            February 12, 2025

                            Lead Product(s) : Ketamine Hydrochloride

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Anavex Life Sciences

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                            WRIB
                            Not Confirmed

                            Anavex Life Sciences

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                            WRIB
                            Not Confirmed
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                            Lead Product(s) : Blarcamesine

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Blarcamesine Data Shows Benefits for Alzheimer’s Disease in 3-Year Treatment

                            Details : ANAVEX2-73 (blarcamesine) is an oral drug that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors. It is under phase 2/3 clinical development for treating Alzheimer's disease.

                            Product Name : ANAVEX2-73

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 13, 2025

                            Lead Product(s) : Blarcamesine

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Denali Therapeutics

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                            WRIB
                            Not Confirmed

                            Denali Therapeutics

                            U.S.A arrow
                            WRIB
                            Not Confirmed
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                            Lead Product(s) : DNL343

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Denali Therapeutics Announces Results for DNL343 in HEALEY ALS Trial

                            Details : DNL343 is an eIF2B agonist, being investigated for the treatment of ALS. eIF2B is an intracellular protein complex that regulates protein synthesis and is required for neuronal health and function.

                            Product Name : DNL343

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 06, 2025

                            Lead Product(s) : DNL343

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Anavex Life Sciences

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                            WRIB
                            Not Confirmed

                            Anavex Life Sciences

                            U.S.A arrow
                            WRIB
                            Not Confirmed
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                            Lead Product(s) : Blarcamesine

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Blarcamesine Receives EMA Filing Acceptance for Treatment of Alzheimer’s Disease

                            Details : ANAVEX2-73 (blarcamesine) is an oral drug that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors. It is under phase 2/3 clinical development for treating Alzheimer's disease.

                            Product Name : ANAVEX2-73

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 23, 2024

                            Lead Product(s) : Blarcamesine

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Clene Nanomedicine

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                            WRIB
                            Not Confirmed

                            Clene Nanomedicine

                            U.S.A arrow
                            WRIB
                            Not Confirmed
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                            Lead Product(s) : CNM-Au8

                            Therapeutic Area : Neurology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Provides Roadmap for Accelerated Approval Pathway for CNM-Au8® Biomarker Data in ALS

                            Details : CNM-Au8 is a catalytically-active gold nanocrystal neuroprotective agent that enhances intracellular energy metabolism, in development for amyotrophic lateral sclerosis.

                            Product Name : CNM-Au8

                            Product Type : Vitamins/Minerals/Inorganic Salts

                            Upfront Cash : Inapplicable

                            December 10, 2024

                            Lead Product(s) : CNM-Au8

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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