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    [{"orgOrder":0,"company":"Neurophth Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"CHINA","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"rAAV2-ND4","moa":"","graph1":"Genetic Disease","graph2":"Phase II\/ Phase III","graph3":"Neurophth Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Neurophth Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"9","companyTruncated":"Neurophth Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Neurophth Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"CHINA","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"rAAV2-ND4","moa":"","graph1":"Genetic Disease","graph2":"Phase II\/ Phase 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Disease","amount2New":0,"dosageForm":"Injection","sponsorNew":"Neurophth Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Neurophth Therapeutics \/ Not Applicable"}]

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                            01

                            Neurophth Therapeutics

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                            Lead Product(s) : Esonadogene Imvoparvovec

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Neurophth Completes Enrollment for Opvika® Phase I/II Clinical Trial in the U.S.

                            Details : Opvika (Esonadogene Imvoparvovec) is a MT-ND4 modulator. It is being evaluated for the treatment of Leber hereditary optic neuropathy caused by ND4 mutation (ND4-LHON).

                            Product Name : Opvika

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            February 19, 2024

                            Lead Product(s) : Esonadogene Imvoparvovec

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Neurophth Therapeutics

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                            Lead Product(s) : NFS-02

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Neurophth Announces First Patient Dosed in Phase I/II Clinical Trial of Second Gene Therapy

                            Details : NFS-02 is Neurophth’s second gene therapy, currently evaluating in multi-region, multi-center Phase I/II clinical trial for the treatment of Leber hereditary optic neuropathy caused by ND1 mutation.

                            Product Name : NFS-02

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            August 17, 2023

                            Lead Product(s) : NFS-02

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Neurophth Therapeutics

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                            Lead Product(s) : Esonadogene Imvoparvovec

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II/ Phase III

                            Sponsor : Yangtze River-CMB International Industry Fund

                            Deal Size : $95.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Neurophth Secures Nearly 95 Million USD in Series C+ Financing for Gene Therapy Clinical Trials

                            Details : The net proceeds will advance clinical trials for Neurophth's core products, enhancing the firm's R&D capabilities and expanding its pipeline, including NFS-01 (esonadogene imvoparvovec), a rAAV2-ND4 gene therapy being developed to treat Leber's heredita...

                            Product Name : NFS-01

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            August 11, 2023

                            Lead Product(s) : Esonadogene Imvoparvovec

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Yangtze River-CMB International Industry Fund

                            Deal Size : $95.0 million

                            Deal Type : Series C Financing

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                            04

                            Neurophth Therapeutics

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                            Lead Product(s) : NR082

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Commercialization of Gene Therapy is coming soon: Neurophth Completes Patient Enrollment for Phase III clinica...

                            Details : NR082 (rAAV2-ND4), a novel recombinant AAV2, containing a mitochondria codon-optimized NADH-dehydrogenase subunit 4 gene which delivers the correct genes to the patients' damaged optic ganglion cells. It is being developed for LHON associated with mtND4 ...

                            Product Name : NR082

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            February 22, 2023

                            Lead Product(s) : NR082

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Neurophth Therapeutics

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                            Lead Product(s) : rAAV2-ND1

                            Therapeutic Area : Genetic Disease

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Neurophth Receives IND Clearance from FDA for AAV-ND1 Gene Therapy of LHON

                            Details : Investigational NFS-02, a novel recombinant adeno-associated viral serotype 2 vector (rAAV2) containing a codon-optimized of NADH-dehydrogenase subunit 1 gene, is a novel ophthalmic injection that is being developed for the treatment of Leber hereditary ...

                            Product Name : NFS-02

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            December 19, 2022

                            Lead Product(s) : rAAV2-ND1

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : rAAV2-ND4

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II/ Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            China CDE Grants Breakthrough Therapy Designation (BTD) to Neurophth's NR082 in LHON

                            Details : NR082 (rAAV2-ND4), a recombinant adeno-associated viral vector, serotype 2, containing human ND4 codon-optimized gene under the control of the cytomegalovirus promoter and enhancer, is a novel gene therapy.

                            Product Name : NR082

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 15, 2022

                            Lead Product(s) : rAAV2-ND4

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Neurophth Therapeutics

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                            Lead Product(s) : NR082

                            Therapeutic Area : Ophthalmology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Neurophth Therapeutics Receives IND Clearance to Initiate Clinical Trial for China AAV-ND4 Gene Therapy NR082 ...

                            Details : INDA Clearance received from USFDA for NFS-01 (NR082), a novel recombinant adeno-associated viral serotype 2 on the basis of results from three investigator-initiated trials which demonstrated favorable results in patients LHON associated ND4 mutation.

                            Product Name : NFS-01

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            January 18, 2022

                            Lead Product(s) : NR082

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

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                            Lead Product(s) : rAAV-ND4

                            Therapeutic Area : Genetic Disease

                            Study Phase : IND Enabling

                            Sponsor : CMG-SDIC Capital

                            Deal Size : $60.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Neurophth Raised Over $60 Million USD in Series-C Financing to Advance Gene Therapies

                            Details : The financing will be used to progress its lead clinical program in LHON to ex-China, enrich R&D pipeline and programs through business development and continue to expand the international standard gene therapy manufacturing platform.

                            Product Name : NFS-01

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            November 22, 2021

                            Lead Product(s) : rAAV-ND4

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : IND Enabling

                            Sponsor : CMG-SDIC Capital

                            Deal Size : $60.0 million

                            Deal Type : Series C Financing

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                            09

                            Neurophth Therapeutics

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                            Lead Product(s) : NR082

                            Therapeutic Area : Ophthalmology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Neurophth Announces IND Approval by the NMPA for Leber Hereditary Optic Neuropathy Gene Therapy

                            Details : NR082, a novel recombinant adeno-associated viral serotype 2 containing a codon-optimized of ND4 gene under the control of the cytomegalovirus promoter and enhancer, is a novel ophthalmic injection that is being developed for the treatment of LHON in ND4...

                            Product Name : NFS-01

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            April 01, 2021

                            Lead Product(s) : NR082

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Neurophth Therapeutics

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                            Lead Product(s) : AAV capsids-gene therapy

                            Therapeutic Area : Ophthalmology

                            Study Phase : Discovery Platform

                            Recipient : Aavnergene

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Neurophth and AAVnerGene Enter Strategic AAV Capsids Partnership for Next-Generation Ophthalmic Gene Therapy

                            Details : Subject to the terms of the agreement, Neurophth will make an initial cash payment to AAVnerGene to test ~100 AAV capsids. Within 6-12 months upon receiving the AAV capsids, Neurophth is responsible for completing the preclinical studies on these capsids...

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            January 19, 2021

                            Lead Product(s) : AAV capsids-gene therapy

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Discovery Platform

                            Recipient : Aavnergene

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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