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Notable stockholders Builders VC","highestDevelopmentStatusID":"8","companyTruncated":"Notable Labs \/ Notable stockholders Builders VC"},{"orgOrder":0,"company":"Notable Labs","sponsor":"CicloMed LLC","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Fosciclopirox","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Notable Labs","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Notable Labs \/ CicloMed LLC","highestDevelopmentStatusID":"8","companyTruncated":"Notable Labs \/ CicloMed LLC"},{"orgOrder":0,"company":"Notable Labs","sponsor":"Boehringer Ingelheim GmbH","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Volasertib","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Notable Labs","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Notable Labs \/ Boehringer Ingelheim GmbH","highestDevelopmentStatusID":"6","companyTruncated":"Notable Labs \/ Boehringer Ingelheim GmbH"},{"orgOrder":0,"company":"Notable Labs","sponsor":"Boehringer Ingelheim GmbH","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Volasertib","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Notable Labs","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Notable Labs \/ Boehringer Ingelheim GmbH","highestDevelopmentStatusID":"6","companyTruncated":"Notable Labs \/ Boehringer Ingelheim GmbH"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

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                          Details : NBL-001 (volasertib) is a PLK-1 inhibitor, small molecule drug candidate. It is being evaluated for the treatment of relapsed/refractory acute myeloid leukemia.

                          Brand Name : NBL-001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 24, 2024

                          Lead Product(s) : Volasertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Boehringer Ingelheim GmbH

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          PharmaVenue
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                          Details : NBL-001 (volasertib) is a PLK-1 inhibitor, small molecule drug candidate. It is being evaluated for the treatment of relapsed/refractory acute myelogenous leukemia.

                          Brand Name : NBL-001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 22, 2024

                          Lead Product(s) : Volasertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Boehringer Ingelheim GmbH

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          PharmaVenue
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                          PharmaVenue
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                          Details : CPX-POM (fosciclopirox) is a patented, parentally administered prodrug of a commercially available topical antifungal agent, ciclopirox. It is under phase 1/2 clinical development for the treatment of bladder cancer and Acute Myeloid Leukemia (AML).

                          Brand Name : CPX-POM

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 18, 2023

                          Lead Product(s) : Fosciclopirox

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : CicloMed LLC

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : The Merger will focus on developing new precision medicines through Notable’s proprietary Predictive Precision Medicines Platform. NBL-001 (volasertib) is derived from PPMP and is a highly potent PLK1 inhibitor inducing cell cycle arrest and apoptosis ...

                          Brand Name : NBL-001

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 16, 2023

                          Lead Product(s) : Volasertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : VBL Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          05

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : The Merger will create a company developing new precision medicines through Notable’s proprietary Predictive Precision Medicines Platform (PPMP). NBL-001 (volasertib) is derived from PPMP and is a highly potent PLK1 inhibitor inducing cell cycle arrest...

                          Brand Name : NBL-001

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 16, 2023

                          Lead Product(s) : Volasertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Notable stockholders Builders VC

                          Deal Size : $10.3 million

                          Deal Type : Private Placement

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                          06

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : The Merger will create a clinical-stage therapeutic platform company developing new precision medicines through Notable’s proprietary PPMP. NBL-001 (volasertib) is derived from PPMP and is a highly potent PLK1 inhibitor inducing cell cycle arrest and a...

                          Brand Name : NBL-001

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 23, 2023

                          Lead Product(s) : Volasertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : VBL Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          07

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Notable’s lead asset derived from PPMP is NBL-001 (volasertib), a highly potent PLK1 inhibitor proven to induce cell cycle arrest and apoptosis in various cancer cells.

                          Brand Name : NBL-001

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 23, 2023

                          Lead Product(s) : Volasertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Builders VC

                          Deal Size : $10.3 million

                          Deal Type : Private Placement

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                          08

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Under the terms of co-development agreement, CicloMed holds the responsibility for executing clinical trial operations while Notable is focused on optimizing Notable’s predictive precision medicine platform with the goal of assessing patient responsive...

                          Brand Name : CPX-POM

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 01, 2021

                          Lead Product(s) : Fosciclopirox,Cytarabine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : CicloMed LLC

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          09

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : Under the terms of this agreement, Oncoheroes will retain the license for the development and commercialization of volasertib for pediatric cancers and continue its commitment towards childhood cancer.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          November 11, 2021

                          Lead Product(s) : Volasertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Oncoheroes Biosciences Inc.

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          10

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : Volasertib is a Polo-like kinase 1 (PLK-1) inhibitor with demonstrated activity in AML and other tumor types with significant unmet medical need. Company plan to fast-track volasertib’s development with phase 2/3 clinical trials in AML and other cancer...

                          Brand Name : NBL-001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 11, 2021

                          Lead Product(s) : Volasertib,Cytarabine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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