Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Boehringer Ingelheim GmbH
Deal Size : Not Applicable
Deal Type : Not Applicable
Notable Labs Receives FDA Clearance to Proceed Further with Volasertib Phase 2 Study
Details : NBL-001 (volasertib) is a PLK-1 inhibitor, small molecule drug candidate. It is being evaluated for the treatment of relapsed/refractory acute myeloid leukemia.
Brand Name : NBL-001
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 24, 2024
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Boehringer Ingelheim GmbH
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Boehringer Ingelheim GmbH
Deal Size : Not Applicable
Deal Type : Not Applicable
Notable Advances in Volasertib Phase 2 Program Using Precision Medicine for Enrollment
Details : NBL-001 (volasertib) is a PLK-1 inhibitor, small molecule drug candidate. It is being evaluated for the treatment of relapsed/refractory acute myelogenous leukemia.
Brand Name : NBL-001
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 22, 2024
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Boehringer Ingelheim GmbH
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Fosciclopirox
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : CicloMed LLC
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : CPX-POM (fosciclopirox) is a patented, parentally administered prodrug of a commercially available topical antifungal agent, ciclopirox. It is under phase 1/2 clinical development for the treatment of bladder cancer and Acute Myeloid Leukemia (AML).
Brand Name : CPX-POM
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 18, 2023
Lead Product(s) : Fosciclopirox
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : CicloMed LLC
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Study Phase : Phase II
Recipient : VBL Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
Notable Labs Closes Merger Transaction with VBL Therapeutics
Details : The Merger will focus on developing new precision medicines through Notable’s proprietary Predictive Precision Medicines Platform. NBL-001 (volasertib) is derived from PPMP and is a highly potent PLK1 inhibitor inducing cell cycle arrest and apoptosis ...
Brand Name : NBL-001
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 16, 2023
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Recipient : VBL Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Notable stockholders Builders VC
Deal Size : $10.3 million
Deal Type : Private Placement
Notable Labs Closes Merger Transaction with VBL Therapeutics
Details : The Merger will create a company developing new precision medicines through Notable’s proprietary Predictive Precision Medicines Platform (PPMP). NBL-001 (volasertib) is derived from PPMP and is a highly potent PLK1 inhibitor inducing cell cycle arrest...
Brand Name : NBL-001
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 16, 2023
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Notable stockholders Builders VC
Deal Size : $10.3 million
Deal Type : Private Placement
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : VBL Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
VBL Therapeutics and Notable Labs Announce Definitive Merger Agreement
Details : The Merger will create a clinical-stage therapeutic platform company developing new precision medicines through Notable’s proprietary PPMP. NBL-001 (volasertib) is derived from PPMP and is a highly potent PLK1 inhibitor inducing cell cycle arrest and a...
Brand Name : NBL-001
Molecule Type : Small molecule
Upfront Cash : Undisclosed
February 23, 2023
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : VBL Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Builders VC
Deal Size : $10.3 million
Deal Type : Private Placement
VBL Therapeutics and Notable Labs Announce Definitive Merger Agreement
Details : Notable’s lead asset derived from PPMP is NBL-001 (volasertib), a highly potent PLK1 inhibitor proven to induce cell cycle arrest and apoptosis in various cancer cells.
Brand Name : NBL-001
Molecule Type : Small molecule
Upfront Cash : Undisclosed
February 23, 2023
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Builders VC
Deal Size : $10.3 million
Deal Type : Private Placement
Lead Product(s) : Fosciclopirox,Cytarabine
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : CicloMed LLC
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the terms of co-development agreement, CicloMed holds the responsibility for executing clinical trial operations while Notable is focused on optimizing Notable’s predictive precision medicine platform with the goal of assessing patient responsive...
Brand Name : CPX-POM
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 01, 2021
Lead Product(s) : Fosciclopirox,Cytarabine
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : CicloMed LLC
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Oncoheroes Biosciences Inc.
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the terms of this agreement, Oncoheroes will retain the license for the development and commercialization of volasertib for pediatric cancers and continue its commitment towards childhood cancer.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
November 11, 2021
Lead Product(s) : Volasertib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Oncoheroes Biosciences Inc.
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Volasertib,Cytarabine
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Volasertib is a Polo-like kinase 1 (PLK-1) inhibitor with demonstrated activity in AML and other tumor types with significant unmet medical need. Company plan to fast-track volasertib’s development with phase 2/3 clinical trials in AML and other cancer...
Brand Name : NBL-001
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 11, 2021
Lead Product(s) : Volasertib,Cytarabine
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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