Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Apollomics Announces Top-Line Results Of Uproleselan Phase 3 Bridging Trial
Details : GMI-1271 (uproleselan) is a E-selectin inhibitor, which is being evaluated to treat adults with relapsed or refractory acute myeloid leukemia.
Product Name : GMI-1271
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 20, 2024
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : The Division of Cancer Treatment and Diagnosis
Deal Size : Inapplicable
Deal Type : Inapplicable
GlycoMimetics Phase 2/3 Uproleselan Study Fails To Meet Primary Cancer Endpoint
Details : GMI-1271 (uproleselan) is a E-selectin inhibitor, which is being evaluated to treat adults with newly diagnosed acute myeloid leukemia (AML) who are 60 years or older.
Product Name : GMI-1271
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 29, 2024
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : The Division of Cancer Treatment and Diagnosis
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
GlycoMimetics Announces Results from Phase 3 Study of Uproleselan in AML
Details : GMI-1271 (uproleselan) is an investigational, first-in-class E-selectin antagonist, which is under phase 3 clinical development for adults with relapsed or refractory acute myeloid leukemia.
Product Name : GMI-1271
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 05, 2024
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
GlycoMimetics Announces Results from Phase 3 of Uproleselan for Relapsed AML Patients
Details : GMI-1271 (uproleselan) is a first-in-class E-selectin antagonist, which is under phase 3 development for the treatment of of adults with relapsed or refractory acute myeloid leukemia.
Product Name : GMI-1271
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
April 06, 2024
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Apollomics Completes Enrollment in Phase 3 Study Of Uproleselan
Details : APL-106 (uproleselan), an E-selectin antagonist, is in Phase 3 trials for relapsed/refractory acute myeloid leukemia (AML).
Product Name : APL-106
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 01, 2024
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : GMI-1271 (uproleselan) is designed to bind to E-selection and block the normal processes controlled by E-selectin. E-selectin is expressed on the surface of blood vessels, and its binding to myeloid cells confers a pro-survival effect via NF-kB signaling...
Product Name : GMI-1271
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 15, 2023
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Ac-225 Lintuzumab,Cladribine,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Patients on study of Actimab-A (Lintuzumab-Ac225) received a median of 2 lines of prior therapy with 57% receiving prior treatment with venetoclax and 67% had adverse cytogenetics with 52% of patients having a TP53 mutation.
Product Name : Actimab-A
Product Type : Antibody
Upfront Cash : Inapplicable
March 11, 2022
Lead Product(s) : Ac-225 Lintuzumab,Cladribine,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The primary endpoint of APL-106 is overall survival and Secondary outcome measures the rate and duration of remission, and whether APL-106 can reduce the rate of oral mucositis, a chemotherapy-related side effect.
Product Name : APL-106
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 22, 2021
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Uproleselan is designed to block E-selectin (an adhesion molecule on cells in the bone marrow) from binding with blood cancer cells as a targeted approach to disrupting well-established mechanisms of leukemic cell resistance within the bone marrow microe...
Product Name : GMI-1271
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 15, 2021
Lead Product(s) : Uproleselan,Etoposide,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Devimistat,Cytarabine,Mitoxantrone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Rafael Pharmaceuticals' lead compound devimistat (CPI-613®) is designed to selectively target the tumor mitochondrial tricarboxylic acid (TCA) cycle, a process essential to tumor cell multiplication and survival.
Product Name : CPI-613
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 28, 2021
Lead Product(s) : Devimistat,Cytarabine,Mitoxantrone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable