Lead Product(s) : ARO-INHBE,Tirzepatide
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Arrowhead Showcases RNAi Candidates for Obesity, Metabolic Disorders
Details : ARO-INHBE is a RNAi-based candidate, is designed to reduce the hepatic expression of the INHBE gene and its secreted gene product, Activin E, being developed for obesity and metabolic diseases.
Product Name : ARO-INHBE
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
March 06, 2025
Lead Product(s) : ARO-INHBE,Tirzepatide
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Amycretin
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Novo Nordisk Completes Phase 1b/2a Trial of Subcutaneous Amycretin for Obesity
Details : NN9487 (amycretin), a unimolecular GLP-1 & amylin receptor agonist intended for once weekly subcutaneous administration. It is being evaluated for the treatment of patients with overweight or obesity.
Product Name : NN9487
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 24, 2025
Lead Product(s) : Amycretin
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ARO-INHBE
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Arrowhead Pharmaceuticals Initiates Phase 1/2a Study of ARO-INHBE for Obesity Treatment
Details : ARO-INHBE, a RNAi-based candidate, is designed to reduce the hepatic expression of the INHBE gene and its secreted gene product, Activin E, being developed for obesity and metabolic diseases.
Product Name : ARO-INHBE
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
December 23, 2024
Lead Product(s) : ARO-INHBE
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MET-097i,MET-233i
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Altasciences Company Inc
Deal Size : Inapplicable
Deal Type : Inapplicable
Altasciences Supports Metsera in Their Early-Stage Clinical Trials for Obesity
Details : ET-097i is an ultra-long-acting injectable amylin analog, fully biased GLP-1 receptor agonist, being investigated in patients with obesity.
Product Name : MET-097i
Product Type : Peptide
Upfront Cash : Inapplicable
November 21, 2024
Lead Product(s) : MET-097i,MET-233i
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Altasciences Company Inc
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MET-097i,MET-233i
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Wellington Management
Deal Size : $215.0 million
Deal Type : Series B Financing
Metsera Secures $215 Million Series B Financing to Further Accelerate Portfolio
Details : The proceeds will be used to further advance its portfolio of NuSH analog peptides, including MET-097i, a novel, fully-biased, potential once-monthly subcutaneously injectable GLP-1 RA.
Product Name : MET-097i
Product Type : Peptide
Upfront Cash : Undisclosed
November 13, 2024
Lead Product(s) : MET-097i,MET-233i
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Wellington Management
Deal Size : $215.0 million
Deal Type : Series B Financing
Lead Product(s) : GSBR-1290
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Structure Therapeutics Doses First Patients in Phase 2b GSBR-1290 Study
Details : GSBR-1290 is an orally-available small molecule agonist of the GLP-1 receptor, a validated drug target which is being evaluated for the treatment of Type 2 Diabetes Mellitus (T2DM) and obesity.
Product Name : GSBR-1290
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 13, 2024
Lead Product(s) : GSBR-1290
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : GSBR-1290
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Structure Therapeutics Reports Positive Data from Phase 2a Obesity Study
Details : GSBR-1290 is a oral non-peptide small molecule GLP-1 receptor agonist which is being evaluated for the treatment of Obesity.
Product Name : GSBR-1290
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 06, 2024
Lead Product(s) : GSBR-1290
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Cannabinoid
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ART27.13 (synthetic cannabinoid) is a highly potent, peripherally restricted synthetic, dual G-Protein Couple Receptor agonist believed to target the cannabinoid receptors CB1 and CB2, which has the potential to increase appetite and food intake.
Product Name : ART27.13
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
April 25, 2023
Lead Product(s) : Cannabinoid
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Cannabinoid
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ART27.13 (synthetic cannabinoid)is a highly potent, peripherally restricted synthetic, dual G-Protein Couple Receptor agonist believed to target the cannabinoid receptors CB1 and CB2 , which has the potential to increase appetite and food intake.
Product Name : ART27.13
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
February 02, 2023
Lead Product(s) : Cannabinoid
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Psilocybine
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Phase I/ Phase II
Sponsor : The Sheba Center for Eating Disorders
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the Agreement, Shortwave will be the exclusive commercial partner in an investigator-initiated, open-label, phase II study of the safety and feasibility of psilocybin-assisted psychotherapy for the treatment of anorexia nervosa (the "Trial").
Product Name : Undisclosed
Product Type : Controlled Substance
Upfront Cash : Undisclosed
August 15, 2022
Lead Product(s) : Psilocybine
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Phase I/ Phase II
Sponsor : The Sheba Center for Eating Disorders
Deal Size : Undisclosed
Deal Type : Agreement