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    [{"orgOrder":0,"company":"Nuvalent","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"NVL-655","moa":"ALK receptor","graph1":"Oncology","graph2":"Phase II","graph3":"Nuvalent","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Nuvalent \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Nuvalent \/ Inapplicable"},{"orgOrder":0,"company":"Nuvalent","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"NVL-655","moa":"ALK receptor","graph1":"Oncology","graph2":"Phase II","graph3":"Nuvalent","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Nuvalent \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Nuvalent \/ Inapplicable"},{"orgOrder":0,"company":"Nuvalent","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"NVL-655","moa":"ALK receptor","graph1":"Oncology","graph2":"Phase II","graph3":"Nuvalent","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Nuvalent \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Nuvalent \/ Inapplicable"},{"orgOrder":0,"company":"Nuvalent","sponsor":"Bain Capital Life Sciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Series B Financing","leadProduct":"Zidesamtinib","moa":"ROS1 receptor","graph1":"Oncology","graph2":"Phase II","graph3":"Nuvalent","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Nuvalent \/ Bain Capital Life Sciences","highestDevelopmentStatusID":"8","companyTruncated":"Nuvalent \/ Bain Capital Life Sciences"},{"orgOrder":0,"company":"Nuvalent","sponsor":"J.P. 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Morgan","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Public Offering","leadProduct":"Zidesamtinib","moa":"ROS1 receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Nuvalent","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Nuvalent \/ J.P. Morgan","highestDevelopmentStatusID":"7","companyTruncated":"Nuvalent \/ J.P. Morgan"}]

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                            01

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                            Lead Product(s) : NVL-655

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Nuvalent Initiates Phase 2 of ALKOVE-1 Trial for ALK-Positive NSCLC and Other Solid Tumors

                            Details : NVL-655 is a novel brain-penetrant ALK-selective tyrosine kinase inhibitor. It is being developed for the treatment of ALK-positive non-small cell lung cancer and other solid tumors.

                            Product Name : NVL-655

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 02, 2024

                            Lead Product(s) : NVL-655

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Nuvalent

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                            AACR Annual meeting
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                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $500.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Nuvalent Announces Pricing of Upsized Public Offering of Common Stock

                            Details : The net proceeds will be used to fund the clinical development of NVL-520 (zidesamtinib), which is being evaluated in early-stage clinical studies for the treatment of non-small cell lung cancer.

                            Product Name : NVL-520

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            September 16, 2024

                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $500.0 million

                            Deal Type : Public Offering

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                            03

                            Nuvalent

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                            AACR Annual meeting
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                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Nuvalent Announces Public Offering of Common Stock

                            Details : The net proceeds will be used to fund the clinical development of NVL-520 (zidesamtinib), which is being evaluated in early-stage clinical studies for the treatment of non-small cell lung cancer.

                            Product Name : NVL-520

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            September 16, 2024

                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : Undisclosed

                            Deal Type : Public Offering

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                            04

                            Nuvalent

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                            AACR Annual meeting
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                            AACR Annual meeting
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                            Lead Product(s) : NVL-655

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Nuvalent Updates on ALK/ ROS1 Inhibitors Supporting Best-in-Class Profiles

                            Details : NVL-655, a potent, brain-penetrant, ALK-selective tyrosine kinase inhibitor (TKI), demonstrated encouraging efficacy and durability in heavily pretreated ALK-positive NSCLC patients.

                            Product Name : NVL-655

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 09, 2024

                            Lead Product(s) : NVL-655

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Nuvalent

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                            AACR Annual meeting
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                            AACR Annual meeting
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                            Lead Product(s) : NVL-330

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Nuvalent Announces First Patient Dosed in HEROEX-1 Phase 1a/1b Trial of NVL-330

                            Details : NVL-330 is a novel brain-penetrant HER2-selective tyrosine kinase inhibitor designed to address the combined medical need for pre-treated patients with advanced HER2-altered NSCLC.

                            Product Name : NVL-330

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 22, 2024

                            Lead Product(s) : NVL-330

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Nuvalent

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                            AACR Annual meeting
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                            Lead Product(s) : NVL-655

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Nuvalent Receives U.S. FDA Breakthrough Therapy Designation for NVL-655

                            Details : NVL-655 is a novel brain-penetrant ALK-selective tyrosine kinase inhibitor. It is being evaluated for patients with locally advanced or metastatic ALK-positive non-small cell lung cancer.

                            Product Name : NVL-655

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 16, 2024

                            Lead Product(s) : NVL-655

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Nuvalent

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                            AACR Annual meeting
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                            Nuvalent

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                            AACR Annual meeting
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                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Nuvalent Receives U.S. FDA Breakthrough Therapy Designation for NVL-520

                            Details : NVL-520 (zidesamtinib) is a novel brain-penetrant ROS1-selective tyrosine kinase inhibitor. It is being evaluated for ROS1-positive metastatic non-small cell lung cancer.

                            Product Name : NVL-520

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 27, 2024

                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Nuvalent

                            U.S.A arrow
                            AACR Annual meeting
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                            Nuvalent

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                            AACR Annual meeting
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                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $300.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Nuvalent Announces Pricing of Public Offering of Common Stock

                            Details : The net proceeds will fund clinical development and research of current or additional pipeline candidates including NVL-520, a ROS1-selective tyrosine kinase inhibitor, NVL-655, an ALK-selective inhibitor, and NVL-330, a HER2-selective tyrosine kinase in...

                            Product Name : NVL-520

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            October 16, 2023

                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $300.0 million

                            Deal Type : Public Offering

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                            09

                            Nuvalent

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                            AACR Annual meeting
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                            Nuvalent

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                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Nuvalent Initiates the Phase 2 Portion of ARROS-1 Clinical Trial for Patients with ROS1-Positive NSCLC and Oth...

                            Details : NVL-520 is a brain-penetrant ROS1-selective inhibitor designed to remain active in tumors that have developed resistance to currently available ROS1 inhibitors, including tumors with the prevalent G2032R resistance mutation and those with the S1986Y/F, L...

                            Product Name : NVL-520

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 09, 2023

                            Lead Product(s) : Zidesamtinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Nuvalent

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                            Lead Product(s) : NVL-655

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Preliminary Phase 1 Dose-Escalation Data from ALKOVE-1 Trial of NVL-655 Demonstrated Activity in Heavily Pre-T...

                            Details : NVL-655 is a brain-penetrant ALK-selective inhibitor designed to selectively inhibit wild-type ALK and its resistance variants over the structurally related TRK family to potentially avoid TRK-related CNS adverse events in patients with advanced alk-posi...

                            Product Name : NVL-655

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 10, 2023

                            Lead Product(s) : NVL-655

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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