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                          Top Deals by Deal Size (USD bn)

                          01

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : NXP900 is an oral SRC/YES1 kinase inhibitor is being investigated in combination with osimertinib (Tagrisso®) in EGFR-mutated non-small cell lung cancer (NSCLC) models.

                          Product Name : NXP900

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 05, 2025

                          Lead Product(s) : NXP900,Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : The proceeds from the offering will used to fund the clinical development of Nuvectis pipeline product such as NXP800. It is being evaluated for Cholangiocarcinoma.

                          Product Name : NXP800

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 07, 2025

                          Lead Product(s) : NXP800

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Lucid Capital Markets

                          Deal Size : $15.5 million

                          Deal Type : Public Offering

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                          03

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : The proceeds from the offering will used to fund the clinical development of Nuvectis pipeline product such as NXP800. It is being evaluated for Cholangiocarcinoma.

                          Product Name : NXP800

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 05, 2025

                          Lead Product(s) : NXP800

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Lucid Capital Markets

                          Deal Size : $13.5 million

                          Deal Type : Public Offering

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                          04

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : The proceeds from the offering will used to fund the clinical development of Nuvectis pipeline product such as NXP800. It is being evaluated for Cholangiocarcinoma.

                          Product Name : NXP800

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 04, 2025

                          Lead Product(s) : NXP800

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Lucid Capital Markets

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          05

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : NXP800 is an oral, small molecule, potentially first-in-class GCN2 kinase activator, being developed for platinum-resistant, ARID1a-mutated ovarian cancer.

                          Product Name : NXP800

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 14, 2024

                          Lead Product(s) : NXP800

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : NXP800 is an oral, small molecule, potentially first-in-class GCN2 kinase activator, which is being evaluated for the treatment of platinum-resistant ARID1a-mutated ovarian cancer.

                          Product Name : NXP800

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 29, 2024

                          Lead Product(s) : NXP800

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : NXP900 is an oral small molecule inhibitor of the SRC Family of Kinases is being evaluated in early-stage clinical trial in combination with Alectinib for the treatment of non-small cell lung cancer.

                          Product Name : NXP900

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 04, 2024

                          Lead Product(s) : NXP900,Alectinib Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : NXP800 is an oral, small molecule, potentially first-in-class GCN2 kinase activator, which is being evaluated for the treatment of platinum-resistant ARID1a-mutated ovarian cancer.

                          Product Name : NXP800

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 14, 2024

                          Lead Product(s) : NXP800

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : The collaboration aims to evaluate NXP800, an oral small molecule, in an Investigator-sponsored clinical trial in cholangiocarcinoma. The FDA granted Orphan Drug Designation for the treatment of cholangiocarcinoma.

                          Product Name : NXP800

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          December 18, 2023

                          Lead Product(s) : NXP800

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Mayo Clinic

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          10

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : NXP900 is a novel inhibitor of the SRC family of kinases with low nanomolar potency against YES1 and SRC. It has demonstrated robust single agent antitumor activity in several in vivo oncological xenograft models.

                          Product Name : NXP900

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 09, 2023

                          Lead Product(s) : NXP900

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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