Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Nurix’s BTK Degrader NX-5948 Shows Positive Results in Waldenstrom’s
Details : NX-5948 is a brain penetrant, small molecule degrader of BTK. NX-5948 is currently being evaluated in a Phase 1 clinical trial in patients with relapsed or refractory Waldenstrom’s Macroglobulinemia
Brand Name : NX-5948
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 19, 2024
Nurix Therapeutics Completes Public Offering with Underwriters’ Option Fully Exercised
Details : Nurix will use net proceeds to fund clinical development of NX-5948, a small molecule BTK degrader for B-cell malignancies.
Brand Name : NX-5948
Molecule Type : Small molecule
Upfront Cash : Undisclosed
April 16, 2024
Nurix Therapeutics Announces Pricing of Upsized $175.0 Million Public Offering
Details : Nurix will use proceeds to fund clinical development of NX-5948, a small molecule BTK degrader for treating B-cell malignancies.
Brand Name : NX-5948
Molecule Type : Small molecule
Upfront Cash : Undisclosed
April 11, 2024
Nurix Reports Clinical Evidence of CNS Activity of NX-5948 for B Cell Malignancies
Details : NX-5948 is an orally available, selective degrader of Bruton’s tyrosine kinase. Currently, it is being evaluated with patients for the treatment of B cell malignancies.
Brand Name : NX-5948
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 09, 2024
Nurix Receives FDA Fast Track Designation for NX-5948 for CLL and SLL
Details : NX-5948 is an investigational, orally bioavailable, small molecule degrader of BTK. It is currently being evaluated in patients with relapsed or refractory B cell malignancies.
Brand Name : NX-5948
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 16, 2024
Details : NX-5948 is an investigational, orally bioavailable, small molecule degrader of BTK. NX-5948 has been designed to lack cereblon immunomodulatory activity for potential applications in indications where sparing immunomodulatory activity may be beneficial.
Brand Name : NX-5948
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 15, 2022
Details : NX-5948 is an investigational, orally bioavailable, small molecule degrader of BTK that, unlike NX-2127, has been designed to lack cereblon immunomodulatory activity for potential applications in indications where sparing immunomodulatory activity may be...
Brand Name : NX-5948
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 10, 2022
Details : NX-5948 was able to cross the blood brain barrier in preclinical models, degrade BTK in both microglia and central nervous system (CNS) resident lymphoma cells, and exert anti-lymphoma activity in a model of primary central nervous system lymphoma (PCNSL...
Brand Name : NX-5948
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 17, 2022
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