Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Nuvectis Pharma Granted Orphan Drug Designation for NXP800 by FDA
Details : NXP800 is an oral, small molecule, potentially first-in-class GCN2 kinase activator, which is being evaluated for the treatment of platinum-resistant ARID1a-mutated ovarian cancer.
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 29, 2024
Nuvectis Pharma Announces Preliminary Data from NXP800 Phase 1b Trial in Ovarian Cancer
Details : NXP800 is an oral, small molecule, potentially first-in-class GCN2 kinase activator, which is being evaluated for the treatment of platinum-resistant ARID1a-mutated ovarian cancer.
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 14, 2024
Lead Product(s) : NXP800
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Mayo Clinic
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The collaboration aims to evaluate NXP800, an oral small molecule, in an Investigator-sponsored clinical trial in cholangiocarcinoma. The FDA granted Orphan Drug Designation for the treatment of cholangiocarcinoma.
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 18, 2023
Lead Product(s) : NXP800
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Mayo Clinic
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : NXP800
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : NXP900 is a novel, small molecule SRC/YES1 kinase inhibitor. The IND has been cleared by the FDA and a Phase 1a dose escalation study is pending commencement.
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 17, 2023
Lead Product(s) : NXP800
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : NXP800 is an oral small molecule inhibitor of the Heat Shock Factor 1 (HSF1) pathway. The HSF1 signaling pathway plays an important role in the initiation and progression of many cancers. It is being investigated in platinum-resistant, ARID1a-mutated ova...
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 10, 2023
Details : NXP800 is an oral small molecule inhibitor of the Heat Shock Factor 1 (HSF1) pathway. The HSF1 signaling pathway plays an important role in the initiation and progression of many cancers.
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Undisclosed
January 04, 2023
Details : The Company is currently developing two drug candidates: NXP800, a clinical-stage HSF1 pathway inhibitor currently in a Phase 1a study in patients with advanced solid tumors, and NXP900, a novel SRC/YES1 kinase inhibitor currently in preclinical with IND...
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 01, 2022
Details : NXP800 is an HSF1 pathway inhibitor currently in a Phase 1 study in patients with advanced solid tumors, and NXP900 is a novel SRC/YES1 kinase inhibitor currently in IND-enabling studies.
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 18, 2022
Lead Product(s) : NXP800
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : NXP800 is an oral small molecule inhibitor of the Heat Shock Factor 1 (HSF1) pathway. The HSF1 signaling pathway plays an important role in the initiation and progression of many cancers.
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 13, 2022
Lead Product(s) : NXP800
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Nuvectis Pharma Announces FDA Clearance of IND for NXP800
Details : In preclinical studies, NXP800 demonstrated potent anti-proliferative activity against a variety of cancer cell lines, and inhibited tumor growth in ARID1A-mutated ovarian clear cell carcinoma and ovarian endometrioid carcinoma human xenograft models.
Brand Name : NXP800
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 21, 2022
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