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Find Clinical Drug Pipeline Developments & Deals by Nykode Therapeutics

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                          01

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                          Details : Nykode regains control of VB10.NEO cancer vaccine program, a proprietary individualized neoantigen vaccine in development for the treatment of locally advanced or metastatic solid tumors.

                          Brand Name : VB10.NEO

                          Molecule Type : Vaccine

                          Upfront Cash : $200.0 million

                          November 08, 2024

                          Lead Product(s) : VB10.NEO,Bempegaldesleukin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Genentech

                          Deal Size : $715.0 million

                          Deal Type : Termination

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                          02

                          PharmaVenue
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                          Details : The collaboration aims to cover evaluation of VB10.16, an off-the-shelf therapeutic cancer vaccine, in combination with Roche’s cancer immunotherapy atezolizumab in patients with advanced cervical cancer. Nykode will sponsor the trial, and Roche will p...

                          Brand Name : VB10.16

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          June 01, 2023

                          Lead Product(s) : VB10.16,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : Undisclosed

                          Deal Type : Expanded Collaboration

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                          03

                          PharmaVenue
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                          PharmaVenue
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                          Details : VB10.16 is a potentially first-in-class off-the-shelf therapeutic cancer vaccine candidate targeting antigens to antigen presenting cells. It is in development for the treatment of human papillomavirus type 16 (HPV16)-positive cancers.

                          Brand Name : VB10.16

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          April 18, 2023

                          Lead Product(s) : VB10.16,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PharmaVenue
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                          Details : Based on the positive interim data and in line with our potential registrational trial strategy, we look forward to starting the VB-C-04 trial in the U.S. The trial is aimed at providing a fast path to making VB10.16 available to patients.

                          Brand Name : VB10.16

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          February 10, 2023

                          Lead Product(s) : VB10.16,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : GOG Foundation

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          05

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : VB10.16 is an off-the-shelf therapeutic cancer vaccine specifically designed to treat HPV16-induced malignancies. The drug candidate has reported interim data from VB-C-02, a Phase 2 trial in heavily pre-treated cervical cancer patients.

                          Brand Name : VB10.16

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          December 20, 2022

                          Lead Product(s) : VB10.16,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : VB10.16 is an off-the-shelf therapeutic cancer vaccine specifically designed to treat HPV16-induced malignancies. Under the terms of the agreement, Merck will supply KEYTRUDA. Nykode retains all commercial rights to VB10.16 worldwide.

                          Brand Name : VB10.16

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          December 06, 2022

                          Lead Product(s) : VB10.16,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : MSD Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : Nykode’s lead product candidates are VB10.16, a therapeutic vaccine for the treatment of human papilloma virus (HPV)-16 induced malignancies which demonstrated positive interim efficacy and safety results from its Phase 2 trial for the treatment of cer...

                          Brand Name : VB10.16

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          November 07, 2022

                          Lead Product(s) : VB10.16,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : VB10.NEO is a proprietary individualized DNA-based neoantigen vaccine in development for the treatment of locally advanced or metastatic solid tumors.

                          Brand Name : VB10.NEO

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          October 26, 2022

                          Lead Product(s) : VB10.NEO,Bempegaldesleukin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Genentech

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : VB10.2210 is designed to induce T cell responses against epitopes from seven additional antigens that are highly conserved across previous and existing SARS-CoV-2 variants. VB10.2210 induced de novo T cell responses to all four non-Spike antigens.

                          Brand Name : VB10.2210

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          September 27, 2022

                          Lead Product(s) : VB10.2210

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : VB10.16 in combination with atezolizumab demonstrated an ORR of 21%, including 2 CRs and 6 PRs, in a heavily pre-treated population of patients with HPV16-positive advanced cervical cancer.

                          Brand Name : VB10.16

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          May 09, 2022

                          Lead Product(s) : VB10.16,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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