Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : VB10.NEO,Bempegaldesleukin
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Genentech
Deal Size : $715.0 million
Deal Type : Termination
Nykode Therapeutics to Regain Control of VB10.NEO Program
Details : Nykode regains control of VB10.NEO cancer vaccine program, a proprietary individualized neoantigen vaccine in development for the treatment of locally advanced or metastatic solid tumors.
Brand Name : VB10.NEO
Molecule Type : Vaccine
Upfront Cash : $200.0 million
November 08, 2024
Lead Product(s) : VB10.NEO,Bempegaldesleukin
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Genentech
Deal Size : $715.0 million
Deal Type : Termination
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Expanded Collaboration
Details : The collaboration aims to cover evaluation of VB10.16, an off-the-shelf therapeutic cancer vaccine, in combination with Roche’s cancer immunotherapy atezolizumab in patients with advanced cervical cancer. Nykode will sponsor the trial, and Roche will p...
Brand Name : VB10.16
Molecule Type : Vaccine
Upfront Cash : Undisclosed
June 01, 2023
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Expanded Collaboration
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : VB10.16 is a potentially first-in-class off-the-shelf therapeutic cancer vaccine candidate targeting antigens to antigen presenting cells. It is in development for the treatment of human papillomavirus type 16 (HPV16)-positive cancers.
Brand Name : VB10.16
Molecule Type : Vaccine
Upfront Cash : Not Applicable
April 18, 2023
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : GOG Foundation
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Based on the positive interim data and in line with our potential registrational trial strategy, we look forward to starting the VB-C-04 trial in the U.S. The trial is aimed at providing a fast path to making VB10.16 available to patients.
Brand Name : VB10.16
Molecule Type : Vaccine
Upfront Cash : Undisclosed
February 10, 2023
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : GOG Foundation
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : VB10.16 is an off-the-shelf therapeutic cancer vaccine specifically designed to treat HPV16-induced malignancies. The drug candidate has reported interim data from VB-C-02, a Phase 2 trial in heavily pre-treated cervical cancer patients.
Brand Name : VB10.16
Molecule Type : Vaccine
Upfront Cash : Not Applicable
December 20, 2022
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VB10.16,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : MSD Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration
Details : VB10.16 is an off-the-shelf therapeutic cancer vaccine specifically designed to treat HPV16-induced malignancies. Under the terms of the agreement, Merck will supply KEYTRUDA. Nykode retains all commercial rights to VB10.16 worldwide.
Brand Name : VB10.16
Molecule Type : Vaccine
Upfront Cash : Undisclosed
December 06, 2022
Lead Product(s) : VB10.16,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : MSD Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Nykode’s lead product candidates are VB10.16, a therapeutic vaccine for the treatment of human papilloma virus (HPV)-16 induced malignancies which demonstrated positive interim efficacy and safety results from its Phase 2 trial for the treatment of cer...
Brand Name : VB10.16
Molecule Type : Vaccine
Upfront Cash : Not Applicable
November 07, 2022
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VB10.NEO,Bempegaldesleukin
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Genentech
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : VB10.NEO is a proprietary individualized DNA-based neoantigen vaccine in development for the treatment of locally advanced or metastatic solid tumors.
Brand Name : VB10.NEO
Molecule Type : Vaccine
Upfront Cash : Not Applicable
October 26, 2022
Lead Product(s) : VB10.NEO,Bempegaldesleukin
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Genentech
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VB10.2210
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : VB10.2210 is designed to induce T cell responses against epitopes from seven additional antigens that are highly conserved across previous and existing SARS-CoV-2 variants. VB10.2210 induced de novo T cell responses to all four non-Spike antigens.
Brand Name : VB10.2210
Molecule Type : Vaccine
Upfront Cash : Not Applicable
September 27, 2022
Lead Product(s) : VB10.2210
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : VB10.16 in combination with atezolizumab demonstrated an ORR of 21%, including 2 CRs and 6 PRs, in a heavily pre-treated population of patients with HPV16-positive advanced cervical cancer.
Brand Name : VB10.16
Molecule Type : Vaccine
Upfront Cash : Not Applicable
May 09, 2022
Lead Product(s) : VB10.16,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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