Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Zilebesiran,Olmesartan Medoxomil
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Alnylam Presents Positive KARDIA-2 Phase 2 Study Results of Zilebesiran
Details : ALN-AGT01 (zilebesiran) investigational, subcutaneously administered RNAi therapeutic targeting angiotensinogen in development for the treatment of hypertension in high unmet need populations.
Product Name : ALN-AGT
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
April 07, 2024
Lead Product(s) : Zilebesiran,Olmesartan Medoxomil
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Zilebesiran,Olmesartan Medoxomil
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : Inapplicable
Deal Type : Inapplicable
Roche and Alnylam's Kardia-2 Study Shows Blood Pressure Drops with Zilebesiran
Details : ALN-AGT01 (zilebesiran) is an investigational, subcutaneously administered RNAi therapeutic targeting angiotensinogen. It is being evaluated in combination with standard of care for hypertension.
Product Name : ALN-AGT
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
March 05, 2024
Lead Product(s) : Zilebesiran,Olmesartan Medoxomil
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Zilebesiran,Olmesartan Medoxomil
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Partnership
Details : Under the partnership, Roche and Alnylam will co-develop and co-commercialise RNAi therapeutic ALN-AGT01 (zilebesiran), an investigational RNAi therapeutic currently in Phase 2 for the treat hypertension in patients with high cardiovascular risk.
Product Name : ALN-AGT
Product Type : Oligonucleotide
Upfront Cash : $310.0 million
July 24, 2023
Lead Product(s) : Zilebesiran,Olmesartan Medoxomil
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Olmesartan Medoxomil,Hydrochlorothiazide
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : A generic combination is approved consisting of olmesartan medoxomil which blocks the vasoconstrictor effects of angiotensin II in vascular smooth muscle and hydrochlorothiazide is a diuretic that inhibits sodium chloride transport in the distal convolut...
Product Name : Benicar HCT-Generic
Product Type : Small molecule
Upfront Cash : Not Applicable
February 28, 2023
Lead Product(s) : Olmesartan Medoxomil,Hydrochlorothiazide
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Amlodipine,Olmesartan Medoxomil
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Approved
Sponsor : Cosette Pharma
Deal Size : Undisclosed
Deal Type : Divestment
Details : The agreement outlines a transition period during which Daiichi Sankyo and Cosette will transfer responsibilities for the manufacture and commercialization of Azor, Benicar, Effient and other products, including quality assurance, pharmacovigilance and r...
Product Name : Azor
Product Type : Small molecule
Upfront Cash : Undisclosed
January 18, 2022
Lead Product(s) : Amlodipine,Olmesartan Medoxomil
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Approved
Sponsor : Cosette Pharma
Deal Size : Undisclosed
Deal Type : Divestment