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Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Repare Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Foundation Medicine","sponsor":"Repare Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Collaboration","leadProduct":"Lunresertib","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Foundation Medicine","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Foundation Medicine \/ Repare Therapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Foundation Medicine \/ Repare Therapeutics"},{"orgOrder":0,"company":"Reneo Pharmaceuticals","sponsor":"OnKure Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Merger","leadProduct":"Fulvestrant","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Reneo Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Reneo Pharmaceuticals \/ OnKure Therapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Reneo Pharmaceuticals \/ OnKure Therapeutics"},{"orgOrder":0,"company":"Pasithea Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"PAS-004","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Pasithea Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Pasithea Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Pasithea Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Quanta Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Cetuximab","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Quanta Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Quanta Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Quanta Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Plus Therapeutics","sponsor":"CPRIT","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Funding","leadProduct":"Rhenium-186 Obisbemeda","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Plus Therapeutics","amount2":0.02,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.02,"dosageForm":"","sponsorNew":"Plus Therapeutics \/ CPRIT","highestDevelopmentStatusID":"6","companyTruncated":"Plus Therapeutics \/ CPRIT"},{"orgOrder":0,"company":"Wistar Institute of Anatomy and Biology","sponsor":"Active Biotech","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Acquisition","leadProduct":"Tasquinimod","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Wistar Institute of Anatomy and Biology","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Wistar Institute of Anatomy and Biology \/ Active Biotech","highestDevelopmentStatusID":"6","companyTruncated":"Wistar Institute of Anatomy and Biology \/ Active Biotech"},{"orgOrder":0,"company":"Immodulon Therapeutics","sponsor":"Precision-Panc","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Vaccine","year":"2024","type":"Not Applicable","leadProduct":"Gemcitabine","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Immodulon Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Immodulon Therapeutics \/ Precision-Panc","highestDevelopmentStatusID":"6","companyTruncated":"Immodulon Therapeutics \/ Precision-Panc"},{"orgOrder":0,"company":"Syncromune","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Vaccine","year":"2024","type":"Not Applicable","leadProduct":"SV-102","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Syncromune","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Syncromune \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Syncromune \/ Not Applicable"}]

Find Oncology Drugs in Phase I Clinical Development

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Details : ABBV-CLS-484 is the first active-site phosphatase inhibitor to enter clinical evaluation as a cancer therapy and is currently in an AbbVie and Calico-led Phase 1 clinical trial in solid tumors.

                          Brand Name : ABBV-CLS-484

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 04, 2023

                          Lead Product(s) : ABBV-CLS-484,Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Calico Life Sciences

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Abbvie Company Banner

                          02

                          Lead Product(s) : OXL001

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Oxilio

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : OXL001, has been developed utilising a novel bio-enabling platform technology, it has been taken into clinical studies which gives its immense potential as a pan-cancer therapy.

                          Brand Name : OXL001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 06, 2022

                          Lead Product(s) : OXL001

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Oxilio

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Quotient

                          03

                          Lead Product(s) : Isatuximab,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Blackstone Life Sciences

                          Deal Size : $330.0 million

                          Deal Type : Collaboration

                          Details : For the Sarclisa® subcutaneous formulation delivery, Sanofi has partnered with drug delivery technology innovator company to advance the development of a subcutaneous delivery for Sarclisa® with the goal of offering a unique patient-centric treatment e...

                          Brand Name : Sarclisa

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          March 15, 2022

                          Lead Product(s) : Isatuximab,Pomalidomide,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Blackstone Life Sciences

                          Deal Size : $330.0 million

                          Deal Type : Collaboration

                          Sanofi Company Banner

                          04

                          Details : Through the agreement, Novosep will perform the process development of the XB002 ADC. which is being evaluated in the early-stage clinical trial studies for the treatment of non-small cell lung cancer and cervical cancer.

                          Brand Name : XB002

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          July 07, 2021

                          Lead Product(s) : XB002,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Exelixis

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Axplora Novasep

                          05

                          Lead Product(s) : UCART22,Alemtuzumab

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Cellectis

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Details : In Cellectis sponsored trials, alemtuzumab is currently used as part of the lymphodepleting regimen for UCART22 in the BALLI-01 clinical trial in relapsed/refractory ALL, and for UCART123 in the AMELI-01 clinical trial in relapsed/refractory AML, but not...

                          Brand Name : UCART22

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          May 11, 2021

                          Lead Product(s) : UCART22,Alemtuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Cellectis

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Sanofi Company Banner

                          06

                          Lead Product(s) : K-NK cells,Cytarabine,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : The trial is expected to provide further clinical proof-of-concept of Kiadis’ K-NK003 product.

                          Brand Name : K-NK003

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          June 25, 2020

                          Lead Product(s) : K-NK cells,Cytarabine,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          07

                          Lead Product(s) : KD033

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : First patient has been dosed in a Phase 1 clinical trial evaluating KD033 in patients with metastatic or locally advanced solid tumors. KD033 is a novel immunotherapy designed to stimulate innate and adaptive immune responses directed to the tumor microe...

                          Brand Name : KD033

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 23, 2020

                          Lead Product(s) : KD033

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          08

                          Lead Product(s) : Interleukin-21-Expanded Haploidentical NK Cells,Cytarabine,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : A poster presentation demonstrates results of multiple FC21-NK infusions in R/R AML patients with CNS disease, treated in an investigator-initiated Phase I/II study.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 29, 2020

                          Lead Product(s) : Interleukin-21-Expanded Haploidentical NK Cells,Cytarabine,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          09

                          Lead Product(s) : Natural killer cells,Filgrastim,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : The abstract showcases the potential of the Company’s NK cell therapy to treat relapsed/refractory acute myeloid leukemia (R/R AML).

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 10, 2020

                          Lead Product(s) : Natural killer cells,Filgrastim,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner

                          10

                          Lead Product(s) : K-NK003,Cytarabine,Decitabine

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : The trial is expected to provide further clinical proof-of-concept of Kiadis’ K-NK003 product.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          February 26, 2020

                          Lead Product(s) : K-NK003,Cytarabine,Decitabine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Sanofi Company Banner