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Biosciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Aura Biosciences \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Aura Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Regen BioPharma","sponsor":"KCL Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2022","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Regen BioPharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Regen BioPharma \/ KCL Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Regen BioPharma \/ KCL Therapeutics"},{"orgOrder":0,"company":"XNK Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SWEDEN","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"XNK03","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"XNK Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"XNK Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"XNK Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Lausanne University Hospital","sponsor":"Prokarium","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"SWITZERLAND","productType":"Undisclosed","year":"2022","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Lausanne University Hospital","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Lausanne University Hospital \/ Prokarium","highestDevelopmentStatusID":"4","companyTruncated":"Lausanne University Hospital \/ Prokarium"},{"orgOrder":0,"company":"Prokarium","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"Salmonella Typhi","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Prokarium","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Prokarium \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Prokarium \/ Inapplicable"},{"orgOrder":0,"company":"Charles River Laboratories, Inc","sponsor":"Curigin","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Large Molecule","year":"2023","type":"Collaboration","leadProduct":"CA102","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Charles River Laboratories, Inc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Charles River Laboratories, Inc \/ Curigin","highestDevelopmentStatusID":"4","companyTruncated":"Charles River Laboratories, Inc \/ Curigin"},{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Vilastobart","moa":"CTLA-4","graph1":"Oncology","graph2":"Preclinical","graph3":"Xilio Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Xilio Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Xilio Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"EpiVax","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Inapplicable","leadProduct":"Personalized Cancer Vaccine","moa":"||Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"EpiVax","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"EpiVax \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"EpiVax \/ Inapplicable"},{"orgOrder":0,"company":"Olimmune","sponsor":"Scopus Biopharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Acquisition","leadProduct":"OLIM-01","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Olimmune","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Olimmune \/ Scopus Biopharma","highestDevelopmentStatusID":"4","companyTruncated":"Olimmune \/ Scopus Biopharma"},{"orgOrder":0,"company":"Scopus Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Inapplicable","leadProduct":"DUET-02","moa":"CpG-STAT3 antisense","graph1":"Oncology","graph2":"Preclinical","graph3":"Scopus Biopharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Scopus Biopharma \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Scopus Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Biovaxys","sponsor":"Procare Pharmaceutical","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Vaccine","year":"2022","type":"Inapplicable","leadProduct":"BVX-0918C","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Biovaxys","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Biovaxys \/ Procare Pharmaceutical","highestDevelopmentStatusID":"4","companyTruncated":"Biovaxys \/ Procare Pharmaceutical"},{"orgOrder":0,"company":"Aravive","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"AVB-500","moa":"||AXL\/GAS6 pathway","graph1":"Oncology","graph2":"Preclinical","graph3":"Aravive","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aravive \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Aravive \/ Inapplicable"},{"orgOrder":0,"company":"Nagourney Cancer Institute","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Alpelisib","moa":"PI3K-alpha","graph1":"Oncology","graph2":"Preclinical","graph3":"Nagourney Cancer Institute","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Nagourney Cancer Institute \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Nagourney Cancer Institute \/ Inapplicable"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Avutometinib","moa":"||RAF\/MEK","graph1":"Oncology","graph2":"Preclinical","graph3":"Verastem Oncology","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Verastem Oncology \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Verastem Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Medicinova","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Ibudilast","moa":"PDE4","graph1":"Oncology","graph2":"Preclinical","graph3":"Medicinova","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Medicinova \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Medicinova \/ Inapplicable"},{"orgOrder":0,"company":"ISA Pharmaceuticals","sponsor":"Cancer Focus Fund","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"NETHERLANDS","productType":"Peptide","year":"2023","type":"Funding","leadProduct":"ISA103","moa":"||PRAME","graph1":"Oncology","graph2":"Preclinical","graph3":"ISA Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ISA Pharmaceuticals \/ Cancer Focus Fund","highestDevelopmentStatusID":"4","companyTruncated":"ISA Pharmaceuticals \/ Cancer Focus Fund"},{"orgOrder":0,"company":"Dewpoint Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"DPTX3496","moa":"CTNNB","graph1":"Oncology","graph2":"Preclinical","graph3":"Dewpoint Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Dewpoint Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Dewpoint Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Dewpoint Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"DPTX3186","moa":"CTNNB","graph1":"Oncology","graph2":"Preclinical","graph3":"Dewpoint Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Dewpoint Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Dewpoint Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Kazia Therapeutics","sponsor":"Vivesto","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"AUSTRALIA","productType":"Other Small Molecule","year":"2025","type":"Divestment","leadProduct":"Cantrixil","moa":"SMETI","graph1":"Oncology","graph2":"Preclinical","graph3":"Kazia Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Kazia Therapeutics \/ Vivesto","highestDevelopmentStatusID":"4","companyTruncated":"Kazia Therapeutics \/ Vivesto"},{"orgOrder":0,"company":"EvolveImmune Therapeutics","sponsor":"Memorial Sloan Kettering Cancer Center","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody-drug Conjugate","year":"2025","type":"Collaboration","leadProduct":"EVOLVE-104","moa":"ULBP2","graph1":"Oncology","graph2":"Preclinical","graph3":"EvolveImmune Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"EvolveImmune Therapeutics \/ Memorial Sloan Kettering Cancer Center","highestDevelopmentStatusID":"4","companyTruncated":"EvolveImmune Therapeutics \/ Memorial Sloan Kettering Cancer Center"},{"orgOrder":0,"company":"Tharimmune","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"HS1940","moa":"PD-1\/VEGF","graph1":"Oncology","graph2":"Preclinical","graph3":"Tharimmune","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Tharimmune \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Tharimmune \/ Inapplicable"},{"orgOrder":0,"company":"Revive Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Bucillamine","moa":"Glutathione","graph1":"Oncology","graph2":"Preclinical","graph3":"Revive Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Revive Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Revive Therapeutics \/ Inapplicable"}]

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01

Lead Product(s) : DB007

Therapeutic Area : Oncology

Study Phase : Preclinical

Sponsor : DotBio

Deal Size : Undisclosed

Deal Type : Collaboration

Details : The collaboration aims to advance the development of DotBio’s Tri-Specific Antibody DB007 for the treatment of Cancer.

Product Name : DB007

Product Type : Antibody

Upfront Cash : Undisclosed

January 09, 2025

Lead Product(s) : DB007

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : DotBio

Deal Size : Undisclosed

Deal Type : Collaboration

Bora Pharmaceutical

02

Lead Product(s) : RVU120

Therapeutic Area : Oncology

Study Phase : Preclinical

Sponsor : Ryvu Therapeutics

Deal Size : $1.0 million

Deal Type : Agreement

Details : RVU120 is a selective, first-in-class dual CDK8/CDK19 kinase inhibitor that has shown signs of clinical activity in treated patients, as well as efficacy in numerous in vitro and in vivo models of hematologic malignancies and solid tumors.

Product Name : RVU120

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

June 07, 2023

Lead Product(s) : RVU120

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Ryvu Therapeutics

Deal Size : $1.0 million

Deal Type : Agreement

Polpharma CB

03

Details : IMGN632 (pivekimab sunirine) is a CD123-targeting ADC in clinical development for hematological malignancies, including blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), and other CD123+ hematologic malignancies.

Product Name : IMGN632

Product Type : Antibody-drug Conjugate

Upfront Cash : Undisclosed

September 12, 2022

Lead Product(s) : Pivekimab Sunirine,Magrolimab

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Gilead Sciences

Deal Size : Undisclosed

Deal Type : Collaboration

Immunogen

04

Lead Product(s) : Undisclosed

Therapeutic Area : Oncology

Study Phase : Preclinical

Sponsor : Rohto Pharmaceutical

Deal Size : Undisclosed

Deal Type : Partnership

Details : The joint venture will be settled in the Haikou National High-tech Zone of south China's Hainan Province, and will focus on research in regenerative medicine and cell culture medium, mesenchymal stem cells-based therapies, as well as related commercial o...

Product Name : Undisclosed

Product Type : Undisclosed

Upfront Cash : Undisclosed

June 24, 2022

Lead Product(s) : Undisclosed

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Rohto Pharmaceutical

Deal Size : Undisclosed

Deal Type : Partnership

Bloomage Company Banner

05

Lead Product(s) : OXL001

Therapeutic Area : Oncology

Study Phase : Preclinical

Sponsor : Oxilio

Deal Size : Undisclosed

Deal Type : Agreement

Details : Oxilio has since progressed the product and now signed a significant service contract with Quotient Sciences, a drug development and manufacturing accelerator, to support the formulation development and preparation of clinical trials for OXL001.

Product Name : OXL001

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

February 18, 2022

Lead Product(s) : OXL001

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Oxilio

Deal Size : Undisclosed

Deal Type : Agreement

Quotient

06

Lead Product(s) : K-NK002

Therapeutic Area : Oncology

Study Phase : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Poster presentation demonstrates similarity between K-NK cells produced with FC21 and PM21 and preclinical data with enhanced K-NK cell production and functionality using PM21.Fc.

Product Name : K-NK002

Product Type : Cell and Gene therapy

Upfront Cash : Inapplicable

December 05, 2020

Lead Product(s) : K-NK002

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Sanofi Company Banner

07

Details : Poseida will apply licensed UniDab binders, which possess significant advantages over traditional single chain variable antibody fragment (scFv) binders, to develop its next generation CAR-T therapies. Targets were not disclosed.

Product Name : Undisclosed

Product Type : Undisclosed

Upfront Cash : Undisclosed

November 23, 2020

Lead Product(s) : Undisclosed

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Amgen Inc

Deal Size : $250.0 million

Deal Type : Licensing Agreement

Abbvie Company Banner

08

Lead Product(s) : Denileukin Diftitox,Undisclosed

Therapeutic Area : Oncology

Study Phase : Preclinical

Sponsor : Eisai

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : Combination of E7777 with an anti-PD-1 agent provided clear benefit both in terms of tumor growth control, and a highly significant improvement in overall survival.

Product Name : E7777

Product Type : Protein

Upfront Cash : Inapplicable

September 11, 2020

Lead Product(s) : Denileukin Diftitox,Undisclosed

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Eisai

Deal Size : Inapplicable

Deal Type : Inapplicable

Dr Reddy Company Banner

09

Lead Product(s) : K-NK003,Isatuximab

Therapeutic Area : Oncology

Study Phase : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Details : The article describes the synergy of mbIL21 expanded NK cells (FC21-NK) modified with a CD38 gene knockout together with an anti-CD38 monoclonal antibody (mAb) for enhanced killing of multiple myeloma cells.

Product Name : K-NK003

Product Type : Cell and Gene therapy

Upfront Cash : Inapplicable

July 22, 2020

Lead Product(s) : K-NK003,Isatuximab

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Sanofi Company Banner

10

Details : Next Generation FRα- Targeting ADC engineered to maximize potential clinical benefit for patients with lower FRα expression. potent anti-tumor activity exhibited in ovarian cancer and other tumor types regardless of FRα expression level.

Product Name : IMGN151

Product Type : Antibody-drug Conjugate

Upfront Cash : Inapplicable

June 22, 2020

Lead Product(s) : IMGN151

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Immunogen