Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
OncoSec Medical Hosting SITC Key Opinion Leader Webinar on Updated Data from the KEYNOTE-695 Study
Details : Tavo works by optimizing cellular uptake of DNA-based IL-12 recruits and primes immune cancer-fighting cells in the tumor leading to systemic immune responses without systemic toxicity.
Brand Name : Tavo
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
November 02, 2021
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : KEYNOTE-695 is OncoSec's registration-directed Phase 2b trial evaluating TAVO, a DNA plasmid-based interleukin-12 (IL-12) + KEYTRUDA® (pembrolizumab) in patients with rigorously confirmed anti-PD-1 checkpoint resistant metastatic melanoma.
Brand Name : TAVO
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
April 15, 2021
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SARS-CoV-2 spike protein plasmid DNA vaccine,Tavokinogene Telseplasmid
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : National Institutes of Health
Deal Size : Not Applicable
Deal Type : Not Applicable
OncoSec Announces First Subjects Dosed in Phase 1 Trial of CORVax12
Details : The CORVax12 vaccine approach combines the co-administration of OncoSec’s TAVO with a DNA-encodable version of the SARS-CoV-2 spike glycoprotein to boost the immunogenicity of the component developed by NIAID Vaccine Research Center scientists.
Brand Name : CORVax12
Molecule Type : Vaccine
Upfront Cash : Not Applicable
January 27, 2021
Lead Product(s) : SARS-CoV-2 spike protein plasmid DNA vaccine,Tavokinogene Telseplasmid
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : National Institutes of Health
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Sirtex Medical
Deal Size : $30.0 million
Deal Type : Agreement
OncoSec Enters into Option Agreement with Sirtex Medical to Co-Promote TAVO™
Details : Through this agreement, Sirtex gains an option to non-exclusively co-promote the Company's lead product candidate, TAVO™ (tavokinogene telseplasmid) in anti-PD-1 checkpoint refractory metastatic melanoma in the U.S.
Brand Name : Tavo
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
January 19, 2021
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Sirtex Medical
Deal Size : $30.0 million
Deal Type : Agreement
Lead Product(s) : Tavokinogene Telseplasmid,Undisclosed
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The applications are directed to the use of OncoSec's interleukin-12 (IL-12)-based immunotherapy platform, including its lead product candidate TAVO™ delivered with the Company's proprietary intratumoral gene electrotransfer system for the treatment of...
Brand Name : Tavo
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
December 10, 2020
Lead Product(s) : Tavokinogene Telseplasmid,Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : OncoSec will present new positive interim data from its KEYNOTE-695 registration-enabled Phase 2b clinical trial investigating TAVO™ in combination with KEYTRUDA® in patients with anti-PD-1 checkpoint refractory metastatic melanoma at 35th SITC Annual...
Brand Name : Tavo
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
November 03, 2020
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SARS-CoV-2 spike protein plasmid DNA vaccine,Tavokinogene Telseplasmid
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : CORVax12 is the first next-generation DNA vaccine candidate to deliver spike (S) protein from SARS-CoV-2 plus immune-stimulating interleukin-12 (IL-12) to elicit T-cell activation and drive robust humoral immunity.
Brand Name : CORVax12
Molecule Type : Vaccine
Upfront Cash : Not Applicable
October 29, 2020
Lead Product(s) : SARS-CoV-2 spike protein plasmid DNA vaccine,Tavokinogene Telseplasmid
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Patent covers the use of intratumoral electroporation of DNA encoding interleukins to treat cancer and is significant because it is not specific to which type of immune-stimulatory interleukin can be used to treat a patient, nor is it limited to a partic...
Brand Name : Tavo
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
October 06, 2020
Lead Product(s) : Tavokinogene Telseplasmid,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tavokinogene Telseplasmid,Nivolumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Anti-PD-1 immune checkpoint therapies, such as OPDIVO®, are an established first-line treatment for advanced melanoma, and encouraging clinical data suggest that they have clinically meaningful activity in the neoadjuvant setting as well.
Brand Name : Tavo
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
August 27, 2020
Lead Product(s) : Tavokinogene Telseplasmid,Nivolumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tavokinogene Telseplasmid,Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : OncoSec Medical Incorporated presented new data further demonstrating the power of OncoSec's next-generation IL-12 plasmid (TAVOPLUS) therapeutic when combined with a T cell stimulator (TAVOPLUS-CD3) or an enhanced chemokine gradient (TAVOPLUS-CXCL9).
Brand Name : Tavo plus
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
June 22, 2020
Lead Product(s) : Tavokinogene Telseplasmid,Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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