Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Bavituximab,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Bavituximab is an antibody designed to reverse immune suppression by inhibiting phosphatidylserine (PS) signaling. Bavituximab blocks tumor immune suppression signaling from PS to multiple immune cell receptor families.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 23, 2023
Lead Product(s) : Bavituximab,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Durvalumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Royal Marsden NHS Foundation Trust
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Results showed MEDI4736 (durvalumab) maintenance therapy did not prolong PFS or OS compared to active surveillance in HER2-negative patients unselected for PD-L1 status.
Brand Name : MEDI4736
Molecule Type : Large molecule
Upfront Cash : Not Applicable
September 12, 2022
Lead Product(s) : Durvalumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Royal Marsden NHS Foundation Trust
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Navicixizumab,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Navicixizumab is an anti-DLL4/VEGF bispecific antibody product candidate that demonstrated antitumor activity in patients who were previously treated with Avastin® (bevacizumab) in a Phase 1b clinical trial.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Not Applicable
September 08, 2022
Lead Product(s) : Navicixizumab,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bavituximab,Temozolomide
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : National Comprehensive Cancer Network
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Treatment led to depletion of immunosuppressive myeloid-derived suppressor cells within the tumor microenvironment, suggesting bavituximab may synergistically combine with checkpoint inhibitors.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 03, 2022
Lead Product(s) : Bavituximab,Temozolomide
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : National Comprehensive Cancer Network
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Navicixizumab,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Overall response rate (ORR) of 43% and median duration of response of 6 months seen with an anti-DLL4/VEGF bispecific antibody, navicixizumab in combination with paclitaxel heavily pretreated platinum-resistant ovarian cancer patients.
Brand Name : OMP-305B83
Molecule Type : Large molecule
Upfront Cash : Not Applicable
April 21, 2022
Lead Product(s) : Navicixizumab,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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