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Pharmaceutical","sponsor":"Turbine","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"HUNGARY","productType":"Cell and Gene therapy","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Ono Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Ono Pharmaceutical \/ Ono Pharmaceutical","highestDevelopmentStatusID":"12","companyTruncated":"Ono Pharmaceutical \/ Ono Pharmaceutical"},{"orgOrder":0,"company":"Ono Pharmaceutical","sponsor":"Ligachem Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"SOUTH KOREA","productType":"Large molecule","year":"2024","type":"Licensing Agreement","leadProduct":"LCB97","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Ono 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Find Clinical Drug Pipeline Developments & Deals by Ono Pharmaceutical

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Ono has made the strategic business decision to allow its option to acquire Equillium’s rights to EQ001 (itolizumab), a monoclonal antibody that targets the CD6-ALCAM signaling pathway, to expire.

                          Brand Name : EQ001

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 31, 2024

                          Lead Product(s) : Itolizumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Recipient : Equillium

                          Deal Size : Undisclosed

                          Deal Type : Termination

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                          02

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Ono will have an exclusive worldwide right to develop, manufacture and commercialize LCB97, a pre-clinical stage antibody-drug conjugate, for solid tumors.

                          Brand Name : LCB97

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 10, 2024

                          Lead Product(s) : LCB97

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Ligachem Biosciences

                          Deal Size : $700.0 million

                          Deal Type : Licensing Agreement

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                          03

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Turbine applied its end-to-end, interpretable cell simulation technology, the Simulated Cell platform, to the in silico discovery of novel targets for potential therapeutic development.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          September 12, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Recipient : Turbine

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          04

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Through the acquisition, the company will utilize Deciphera's pipeline and approved products, which include Qinlock (ripretinib), indicated for treating advanced gastrointestinal stromal tumor.

                          Brand Name : Qinlock

                          Molecule Type : Small molecule

                          Upfront Cash : $2,400.0 million

                          June 11, 2024

                          Lead Product(s) : Ripretinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Deciphera Pharmaceuticals

                          Deal Size : $2,400.0 million

                          Deal Type : Acquisition

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                          05

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Through the acquisition, the company will utilize Deciphera's pipeline and approved products, which include Qinlock (ripretinib), indicated for treating fourth-line gastrointestinal stromal tumors.

                          Brand Name : Qinlock

                          Molecule Type : Small molecule

                          Upfront Cash : $2,400.0 million

                          April 29, 2024

                          Lead Product(s) : Ripretinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Deciphera Pharmaceuticals

                          Deal Size : $2,400.0 million

                          Deal Type : Acquisition

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                          06

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Ono and PRISM will jointly develop a candidate for Ono’s oncology target using PepMetics, small molecules that mimic 3D structures of alpha-helix and beta-turn peptides for drug discovery.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          April 25, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Recipient : Prism Biolab

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          07

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : ONO-4059 (tirabrutinib) is a highly selective irreversible Bruton's tyrosine kinase inhibitor. It is being evaluated for patients with relapsed or refractory primary central nervous system lymphoma.

                          Brand Name : ONO-4059

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 25, 2024

                          Lead Product(s) : Tirabrutinib Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Ono Pharmaceutical collaborates with Sibylla to use PPI-FIT technology for developing candidates for CNS disorders.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 14, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Recipient : Sibylla Biotech

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : InveniAI collaborates with Ono to identify novel therapeutic targets in various diseases, using its AI platforms AlphaMeld and ChatAlphaMeld for drug discovery.

                          Brand Name : Undisclosed

                          Molecule Type : Undisclosed

                          Upfront Cash : Undisclosed

                          February 20, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Technology

                          Highest Development Status : Discovery Platform

                          Recipient : InveniAI

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          10

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Ono obtained rights for NM49 from Numab for global development and commercialization. NM49 is a multi-specific antibody designed to activate tumor-associated macrophage phagocytosis for cancer.

                          Brand Name : NM49

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          February 14, 2024

                          Lead Product(s) : NM49

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Numab Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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