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I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Bicycle Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Bicycle Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Bicycle Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Peptide","year":"2022","type":"Inapplicable","leadProduct":"BT5528","moa":"||Ephrin type A receptor 2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Bicycle Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Bicycle Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Bicycle Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Bicycle Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Peptide","year":"2020","type":"Inapplicable","leadProduct":"BT5528","moa":"||Ephrin type A receptor 2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Bicycle Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Bicycle Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Bicycle Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Clinigen Group","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Undisclosed","year":"2020","type":"Inapplicable","leadProduct":"Nivolumab","moa":"||IL-2 receptor","graph1":"Oncology","graph2":"Phase I","graph3":"Clinigen Group","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Clinigen Group \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Clinigen Group \/ Inapplicable"},{"orgOrder":0,"company":"Mereo BioPharma Group","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Etigilimab","moa":"||TIGIT protein","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Mereo BioPharma Group","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Mereo BioPharma Group \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Mereo BioPharma Group \/ Inapplicable"},{"orgOrder":0,"company":"Bicycle Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Peptide-drug Conjugate","year":"2022","type":"Inapplicable","leadProduct":"Nivolumab","moa":"||Nectin-4","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Bicycle Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Bicycle Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Bicycle Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Mereo BioPharma Group","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Etigilimab","moa":"||TIGIT protein","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Mereo BioPharma Group","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Mereo BioPharma Group \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Mereo BioPharma Group \/ Inapplicable"},{"orgOrder":0,"company":"Mereo BioPharma Group","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Etigilimab","moa":"||TIGIT protein","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Mereo BioPharma Group","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Mereo BioPharma Group \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Mereo BioPharma Group \/ Inapplicable"},{"orgOrder":0,"company":"Bristol Myers Squibb","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"Nivolumab","moa":"||PD-1","graph1":"Oncology","graph2":"Approved FDF","graph3":"Bristol Myers Squibb","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Bristol Myers Squibb \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Bristol Myers Squibb \/ Inapplicable"},{"orgOrder":0,"company":"Bristol Myers Squibb","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"Nivolumab","moa":"||PD-1","graph1":"Oncology","graph2":"Approved FDF","graph3":"Bristol Myers Squibb","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Bristol Myers Squibb \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Bristol Myers Squibb \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals for Opdivo

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                            01

                            Axplora

                            Germany
                            CPhI Japan
                            Booth #IT-03
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                            Virtual BoothAxplora is your partner of choice for complex APIs.

                            Lead Product(s) : XB002,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Exelixis

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Novasep Secures Manufacturing Deal with US Biotech for ADC Drug Candidate

                            Details : Through the agreement, Novosep will perform the process development of the XB002 ADC. which is being evaluated in the early-stage clinical trial studies for the treatment of non-small cell lung cancer and cervical cancer.

                            Product Name : XB002

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Undisclosed

                            July 07, 2021

                            Lead Product(s) : XB002,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Exelixis

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            Axplora CB

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                            02

                            Bristol Myers Squibb

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                            BioTrinity 2025
                            Not Confirmed

                            Bristol Myers Squibb

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                            BioTrinity 2025
                            Not Confirmed
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                            Lead Product(s) : Nivolumab,Cisplatin,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BMS Gets Positive CHMP Opinion for Perioperative Opdivo + Chemo in NSCLC

                            Details : Opdivo (nivolumab) a PD-1 inihibitor in combination with chemotherapy is indicated for the treatment of adult patients with resectable non-small cell lung cancer.

                            Product Name : Opdivo

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 28, 2025

                            Lead Product(s) : Nivolumab,Cisplatin,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Bristol Myers Squibb

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                            BioTrinity 2025
                            Not Confirmed

                            Bristol Myers Squibb

                            U.S.A arrow
                            BioTrinity 2025
                            Not Confirmed
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                            Lead Product(s) : Nivolumab,Hyaluronidase

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BMS Gets Positive CHMP Opinion for Subcutaneous Opdivo in Solid Tumors

                            Details : Opdivo Qvantig (nivolumab & hyaluronidase) subcutaneous version PD-1 inhibitor is indicated for the treatment of carcinoma, renal cell.

                            Product Name : Opdivo Qvantig

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 28, 2025

                            Lead Product(s) : Nivolumab,Hyaluronidase

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            I-Mab Biopharma

                            China arrow
                            BioTrinity 2025
                            Not Confirmed

                            I-Mab Biopharma

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                            BioTrinity 2025
                            Not Confirmed
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                            Lead Product(s) : Givastomig,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : ABL Bio

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            I-Mab Announces Accelerated Givastomig Phase 1b Study Progress

                            Details : TJ033721 (givastomig) is a potential best-in-class, Claudin 18.2 (CLDN18.2) x 4-1BB bispecific antibody, targeting CLDN18.2-positive tumor cells.

                            Product Name : TJ033721

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 07, 2025

                            Lead Product(s) : Givastomig,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : ABL Bio

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Replimune

                            U.S.A arrow
                            BioTrinity 2025
                            Not Confirmed

                            Replimune

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                            BioTrinity 2025
                            Not Confirmed
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                            Lead Product(s) : RP2,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Replimune Announces BLA Acceptance and Priority Review for RP1 in Advanced Melanoma

                            Details : RP2 is an oncolytic immunotherapy which expresses an anti-CTLA-4 antibody-like molecule, it is being investigated in combination with nivolumab is being investigated in metastatic uveal melanoma.

                            Product Name : RP2

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 21, 2025

                            Lead Product(s) : RP2,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Replimune

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                            BioTrinity 2025
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                            Replimune

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                            BioTrinity 2025
                            Not Confirmed
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                            Lead Product(s) : RP2,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Replimune Advances RP2 Program with First Patients in Uveal Melanoma Trials

                            Details : RP2 is an oncolytic immunotherapy which expresses an anti-CTLA-4 antibody-like molecule, it is being investigated in combination with nivolumab is being investigated in metastatic uveal melanoma.

                            Product Name : RP2

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 08, 2025

                            Lead Product(s) : RP2,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Bristol Myers Squibb

                            U.S.A arrow
                            BioTrinity 2025
                            Not Confirmed

                            Bristol Myers Squibb

                            U.S.A arrow
                            BioTrinity 2025
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : Nivolumab,Ipilimumab

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bristol Myers Squibb Receives EC Approval for Opdivo® Plus Yervoy® for MSI-High

                            Details : Opdivo (nivolumab) in combination with Yervoy (ipilimumab) is being evaluated for the treatment of microsatellite instability–high or mismatch repair deficient metastatic colorectal cancer.

                            Product Name : Opdivo

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            December 23, 2024

                            Lead Product(s) : Nivolumab,Ipilimumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Immatics

                            Germany arrow
                            BioTrinity 2025
                            Not Confirmed

                            Immatics

                            Germany arrow
                            BioTrinity 2025
                            Not Confirmed
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                            Lead Product(s) : IMA203,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Jefferies

                            Deal Size : $150.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Immatics Announces Proposed $150 Million Public Offering

                            Details : The proceeds will fund the continued research and development of company's pipeline including IMA203 TCR-T, currently being evaluated in a Phase 1 trial in patients with solid tumors expressing PRAME.

                            Product Name : IMA203

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            October 10, 2024

                            Lead Product(s) : IMA203,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Jefferies

                            Deal Size : $150.0 million

                            Deal Type : Public Offering

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                            09

                            Immatics

                            Germany arrow
                            BioTrinity 2025
                            Not Confirmed

                            Immatics

                            Germany arrow
                            BioTrinity 2025
                            Not Confirmed
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                            Lead Product(s) : IMA203,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Jefferies

                            Deal Size : $150.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Immatics Announces Pricing of $150 Million Public Offering

                            Details : The proceeds will fund the continued research and development of company's pipeline including IMA203 TCR-T, currently being evaluated in a Phase 1 trial in patients with solid tumors expressing PRAME.

                            Product Name : IMA203

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            October 10, 2024

                            Lead Product(s) : IMA203,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Jefferies

                            Deal Size : $150.0 million

                            Deal Type : Public Offering

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                            10

                            Immatics

                            Germany arrow
                            BioTrinity 2025
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                            Immatics

                            Germany arrow
                            BioTrinity 2025
                            Not Confirmed
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                            Lead Product(s) : IMA203,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Immatics Updates on ACTengine® IMA203 Data And SUPRAME Trial Plans

                            Details : IMA203 TCR therapy being evaluated with nivolumab, against an HLA-A*02-presented peptide derived from preferentially expressed antigen in melanoma.

                            Product Name : IMA203

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            October 10, 2024

                            Lead Product(s) : IMA203,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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