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                          01

                          Lead Product(s) : Laquinimod

                          Therapeutic Area : Ophthalmology

                          Study Phase : Phase I

                          Sponsor : Active Biotech

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Details : Through the agreement, Active Biotech will get the material for the clinical development of the eye-drop formulation of ABR-215062 (laquinimod), which is used for the treatment of non-infectious non-anterior uveitis.

                          Brand Name : ABR-215062

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 04, 2021

                          Lead Product(s) : Laquinimod

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Active Biotech

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Famar

                          02

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                          Details : The combined company will focus on the development of TH103, a fully humanized, recombinant fusion protein, for patients with neovascular age-related macular degeneration.

                          Brand Name : TH103

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          November 08, 2024

                          Lead Product(s) : TH103

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Kalaris Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          Details : PMC-403 is an antibody therapeutic candidate with a novel mechanism of action: it activates the TIE2 receptor. It is being investigated for Neovascular Age-related Macular Degeneration.

                          Brand Name : PMC-403

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 14, 2024

                          Lead Product(s) : PMC-403

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          Details : CU200 is a novel fusion protein consisting of human transferrin linked to human tumstatin. Currently, it is being investigating for the treatment of patients suffering from diabetic macular edema.

                          Brand Name : OCU200

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 09, 2024

                          Lead Product(s) : OCU200

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          PharmaVenue
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                          Details : The funds will advance the development of ONL1204 Ophthalmic Solution by initiating a Phase 2 global study for treating GA associated with dry age-related macular degeneration.

                          Brand Name : ONL1204

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 13, 2024

                          Lead Product(s) : ONL1204

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Johnson & Johnson

                          Deal Size : $65.0 million

                          Deal Type : Series D Financing

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                          Details : BI 771716, developed with technology licensed from CDR-Life, is a highly specific antibody fragment of reduced size, enabling an optimized penetration in patients with GA disease pathology.

                          Brand Name : BI 771716

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 05, 2024

                          Lead Product(s) : BI 771716

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          PharmaVenue
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                          Details : AIV007 is a novel prolonged drug release formulation. It targets VEGFR, PDGFR, and FGFR to address macular degeneration and diabetic macular edema.

                          Brand Name : AIV007

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 26, 2024

                          Lead Product(s) : Lenvatinib

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          PharmaVenue
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                          Details : AIV007 is a novel prolonged drug release formulation. It targets VEGFR, PDGFR, and FGFR to address macular degeneration and diabetic macular edema.

                          Brand Name : AIV007

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 23, 2024

                          Lead Product(s) : Lenvatinib

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          PharmaVenue
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                          Details : The acquisition includes Restoret (EYE103), a first-in-class tetravalent, tri-specific antibody and late-phase candidate for diabetic macular edema and neovascular age-related macular degeneration.

                          Brand Name : Restoret

                          Molecule Type : Large molecule

                          Upfront Cash : $1,300.0 million

                          July 12, 2024

                          Lead Product(s) : EYE103

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Merck & Co

                          Deal Size : $3,000.0 million

                          Deal Type : Acquisition

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                          Details : PMC-403 is a novel TIE2-activating antibody with the mechanism of stabilizing pathological and leaky blood vessels. It is being evaluated for the treatment of nAMD.

                          Brand Name : PMC-403

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 01, 2024

                          Lead Product(s) : PMC-403

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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