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Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2023","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2023","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2023","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2023","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2024","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2024","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2022","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2021","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2021","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"AmbioPharm","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2022","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution\/Drops","sponsorNew":"OKYO Pharma \/ AmbioPharm","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ AmbioPharm"},{"orgOrder":0,"company":"Bicycle Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2020","type":"Inapplicable","leadProduct":"THR-149","moa":"Plasma kallikrein","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Bicycle Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Bicycle Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Bicycle Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"OKYO Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"UNITED KINGDOM","productType":"Peptide","year":"2025","type":"Inapplicable","leadProduct":"Urcosimod","moa":"Chemerin receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"OKYO Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution","sponsorNew":"OKYO Pharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OKYO Pharma \/ Inapplicable"}]

    Find Ophthalmology Drugs in Phase II Clinical Development

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                            01

                            Aurion Biotech

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                            Aurion Biotech

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                            Lead Product(s) : Neltependocel

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Alcon inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon Acquires Aurion Biotech To Advance Corneal Cell Therapy

                            Details : Aurion will operate as a separate company with full support from Alcon to advance its clinical-stage allogeneic cell therapy asset, AURN001 for the treatment of Corneal Edema in adult.

                            Product Name : AURN001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            March 26, 2025

                            Lead Product(s) : Neltependocel

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Alcon inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            02

                            Signal 12

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                            Peptide Therapy Summit
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                            Signal 12

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                            Lead Product(s) : Progesterone

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Signal12 Advances Pro-ocular™ to Phase 3 for Ocular GVHD

                            Details : Pro-ocular (progesterone) is a novel drop-free therapy poised to revolutionize the treatment of ocular Graft-versus-Host Disease (oGvHD).

                            Product Name : Pro-ocular

                            Product Type : Hormone

                            Upfront Cash : Inapplicable

                            March 18, 2025

                            Lead Product(s) : Progesterone

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            OKYO Pharma

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                            Peptide Therapy Summit
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                            OKYO Pharma

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                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            OKYO Seeks FDA Fast Track for Urcosimod in Neuropathic Corneal Pain Treatment

                            Details : OK-101 (urcosimod) is a novel, non-opioid therapeutic candidate, is designed to target and alleviate the debilitating pain associated with corneal nerve damage.

                            Product Name : OK-101

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            March 10, 2025

                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Ashvattha Therapeutics

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                            Peptide Therapy Summit
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                            Ashvattha Therapeutics

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                            Lead Product(s) : Hydroxyl Dendrimer,Aflibercept

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Ashvattha Presents Positive Phase 2 Data On Migaldendranib at Angiogenesis 2025

                            Details : D-4517.2 (migaldendranib) is a novel subcutaneously (subQ) administered nanomedicine treatment for retinal diseases and has the potential to be administered at home.

                            Product Name : D-4517.2

                            Product Type : Other Large Molecule

                            Upfront Cash : Inapplicable

                            February 10, 2025

                            Lead Product(s) : Hydroxyl Dendrimer,Aflibercept

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Ashvattha Therapeutics

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                            Peptide Therapy Summit
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                            Ashvattha Therapeutics

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                            Lead Product(s) : Hydroxyl Dendrimer

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Tribe Capital

                            Deal Size : $50.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Ashvattha Therapeutics Announces $50M Financing and Interim Phase 2 Results

                            Details : The funding will enable Ashvattha to complete the ongoing mid-stage trial studies of D-4517.2 (dendranib). It is being evaluated for the treatment of wet-AMD.

                            Product Name : D-4517.2

                            Product Type : Other Large Molecule

                            Upfront Cash : Undisclosed

                            January 13, 2025

                            Lead Product(s) : Hydroxyl Dendrimer

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Tribe Capital

                            Deal Size : $50.0 million

                            Deal Type : Series B Financing

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                            06

                            4D Molecular Therapeutics

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                            Peptide Therapy Summit
                            Not Confirmed

                            4D Molecular Therapeutics

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                            Lead Product(s) : Aflibercept

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            4DMT Announces Positive Data for 4D-150 in DME and FDA Registrational Path

                            Details : 4D-150 is an AAV-based gene therapy comprised of miRNA targeting VEGF-C and codon-optimized sequence encoding aflibercept. It is under development for diabetic macular edema.

                            Product Name : 4D-150

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 10, 2025

                            Lead Product(s) : Aflibercept

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Galimedix Therapeutics

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                            Peptide Therapy Summit
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                            Galimedix Therapeutics

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                            Peptide Therapy Summit
                            Not Confirmed
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                            Lead Product(s) : GAL-101

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Galimedix Therapeutics Initiates Pivotal Phase 2 Study with GAL-101 Eye Drops in Dry AMD

                            Details : GAL-101 is a beta amyloid A4 protein modulator, which is being evaluated for the treatment of patients with dry age-related macular degeneration.

                            Product Name : GAL-101

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 23, 2024

                            Lead Product(s) : GAL-101

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Opus Genetics

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                            Peptide Therapy Summit
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                            Opus Genetics

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                            Lead Product(s) : APX3330

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Opus Genetics Receives FDA Agreement for Phase 3 Trial of APX3330 in Diabetic Retinopathy

                            Details : APX3330 is an oral small-molecule inhibitor of Ref-1, which is currently being evaluated for the treatment of patients with non-proliferative diabetic retinopathy.

                            Product Name : APX3330

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 19, 2024

                            Lead Product(s) : APX3330

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Eclipse Life Sciences

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                            Peptide Therapy Summit
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                            Eclipse Life Sciences

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                            Lead Product(s) : Fluocinolone Acetonide

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Eclipse Initiates Phase 2 Study for Steroid Implant in Diabetic Macular Edema

                            Details : EC-104 (fluocinolone acetonide) extended release, a novel intravitreal corticosteroid implant is being investigated for the treatment of diabetic macular edema (DME).

                            Product Name : EC-104

                            Product Type : Steroid

                            Upfront Cash : Inapplicable

                            December 08, 2024

                            Lead Product(s) : Fluocinolone Acetonide

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Lineage Cell Therapeutics

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                            Peptide Therapy Summit
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                            Lineage Cell Therapeutics

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                            Lead Product(s) : RG6501

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : H.C. Wainwright & Co

                            Deal Size : $66.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Lineage Cell Announces First Closing of up to $66 Million Registered Direct Offering

                            Details : The proceeds will be used to advance OpRegen (also known as RG6501) into a multi-center phase 2 or 3 clinical trial for the treatment of ocular disorders, including advanced dry AMD with GA.

                            Product Name : OpRegen

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            November 21, 2024

                            Lead Product(s) : RG6501

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : H.C. Wainwright & Co

                            Deal Size : $66.0 million

                            Deal Type : Public Offering

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