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bio","sponsor":"DelSiTech","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Agreement","leadProduct":"Avacincaptad Pegol","moa":"C5","graph1":"Ophthalmology","graph2":"Phase III","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ DelSiTech","highestDevelopmentStatusID":"10","companyTruncated":"IVERIC bio \/ DelSiTech"},{"orgOrder":0,"company":"IVERIC bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Inapplicable","leadProduct":"Avacincaptad Pegol","moa":"C5","graph1":"Ophthalmology","graph2":"Phase III","graph3":"IVERIC bio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"IVERIC bio \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"IVERIC bio \/ Inapplicable"},{"orgOrder":0,"company":"Glaukos","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Travoprost","moa":"FP receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Glaukos","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intraocular Implant","sponsorNew":"Glaukos \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Glaukos \/ Inapplicable"},{"orgOrder":0,"company":"Glaukos","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"HPAPI","year":"2023","type":"Inapplicable","leadProduct":"Travoprost","moa":"FP receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Glaukos","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intraocular Implant","sponsorNew":"Glaukos \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Glaukos \/ Inapplicable"},{"orgOrder":0,"company":"Glaukos","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Travoprost","moa":"FP receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Glaukos","amount2":0,"highestDevelopmentShortName":"Ph 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SA","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Nitric Oxide-Donating Prostaglandin Analog","moa":"sGC","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Nicox SA","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution","sponsorNew":"Nicox SA \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Nicox SA \/ Inapplicable"},{"orgOrder":0,"company":"Celanese","sponsor":"Glaukos","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"HPAPI","year":"2023","type":"Agreement","leadProduct":"Travoprost","moa":"FP receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Celanese","amount2":0,"highestDevelopmentShortName":"Ph 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Sciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Antibody-drug Conjugate","year":"2025","type":"Inapplicable","leadProduct":"Tarcocimab Tedromer","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Kodiak Sciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Kodiak Sciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Kodiak Sciences \/ Inapplicable"},{"orgOrder":0,"company":"Sydnexis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Atropine Sulfate","moa":"mAChRs","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Sydnexis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution","sponsorNew":"Sydnexis \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Sydnexis \/ Inapplicable"},{"orgOrder":0,"company":"Nicox SA","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"HPAPI","year":"2025","type":"Inapplicable","leadProduct":"Bimatoprost","moa":"Prostanoid FP receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Nicox SA","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution","sponsorNew":"Nicox SA \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Nicox SA \/ Inapplicable"}]

Find Ophthalmology Drugs in Phase III Clinical Development

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01

Details : The company will present patient-reported outcomes for AGN-190584, an investigational therapy for the treatment of presbyopia. Recently the company submitted an NDA to the U.S. Food and Drug Administration based on data from the Phase 3 GEMINI 1 and GEMI...

Product Name : AGN-190584

Product Type : Small molecule

Upfront Cash : Not Applicable

April 27, 2021

Lead Product(s) : Pilocarpine Hydrochloride

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : AbbVie Inc

Deal Size : Not Applicable

Deal Type : Not Applicable

Abbvie CB

02

Details : Allergan has submitted a New Drug Application to the U.S. Food and Drug Administration for investigational AGN-190584 (pilocarpine 1.25%) ophthalmic solution for the treatment of presbyopia. The FDA is expected to act on the NDA by the end of 2021.

Product Name : AGN-190584

Product Type : Small molecule

Upfront Cash : Not Applicable

February 25, 2021

Lead Product(s) : Pilocarpine Hydrochloride

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : AbbVie Inc

Deal Size : Not Applicable

Deal Type : Not Applicable

Abbvie CB

03

Details : Data presented at the meeting will include an analysis examining the safety and efficacy of DURYSTA™ and a second analysis of data from the Phase 3 ARTEMIS studies that identify different characteristics of glaucoma patients who may respond after being...

Product Name : AGN-190584

Product Type : Small molecule

Upfront Cash : Not Applicable

November 06, 2020

Lead Product(s) : Pilocarpine Hydrochloride

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Abbvie CB

04

Details : Phase 3 GEMINI 1 and 2 studies evaluating AGN-190584 (pilocarpine 1.25%) ophthalmic solution met the primary endpoint, reaching statistical significance in improvement in near vision.

Product Name : AGN-190584

Product Type : Small molecule

Upfront Cash : Not Applicable

October 28, 2020

Lead Product(s) : Pilocarpine Hydrochloride

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : AbbVie Inc

Deal Size : Not Applicable

Deal Type : Not Applicable

Abbvie CB

05

Details : Allergan, an AbbVie has informed Molecular Partners of their intent to withdraw application filings with both the EMA and the Japanese Regulatory Agency (PMDA) for abicipar pegol, a novel DARPin therapeutic for patients with neovascular (wet) age-related...

Product Name : Abicipar

Product Type : Large molecule

Upfront Cash : Not Applicable

July 20, 2020

Lead Product(s) : Abicipar Pegol

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Abbvie CB

06

Details : A New Drug Application (NDA) for Bimatoprost SR is currently under review with the U.S. Food and Drug Administration, and if approved, has the potential to be the first and only biodegradable.

Product Name : Undisclosed

Product Type : HPAPI

Upfront Cash : Inapplicable

February 25, 2020

Lead Product(s) : Bimatoprost

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

Abbvie CB

07

ATTD
Not Confirmed
ATTD
Not Confirmed

Details : 4D-150 is an AAV-based gene therapy comprised of miRNA targeting VEGF-C & codon-optimized sequence encoding aflibercept. It is under development for neovascular (wet) age-related macular degeneration.

Product Name : 4D-150

Product Type : Cell and Gene therapy

Upfront Cash : Inapplicable

March 10, 2025

Lead Product(s) : Aflibercept,Undisclosed

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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08

ATTD
Not Confirmed
ATTD
Not Confirmed

Details : KSI-301 (tarcocimab tedromer) is designed to maintain potent and effective drug levels in ocular tissues for longer than existing anti-VEGF therapies. It is evaluated for diabetic retinopathy.

Product Name : KSI-301

Product Type : Antibody-drug Conjugate

Upfront Cash : Inapplicable

March 10, 2025

Lead Product(s) : Tarcocimab Tedromer

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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09

ATTD
Not Confirmed
ATTD
Not Confirmed

Details : Nyxol (phentolamine mesylate) an alpha1/2 adrenergic receptor inhibitor, is being investigated for decreased visual acuity under low light conditions following keratorefractive surgery.

Product Name : Nyxol

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

February 26, 2025

Lead Product(s) : Phentolamine Mesylate

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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10

ATTD
Not Confirmed
ATTD
Not Confirmed

Details : Lytenava (bevacizumab gamma) is a recombinant humanized mAb that selectively binds with high affinity to VEGF. It is indicated for the treatment of wet age-related macular degeneration.

Product Name : Lytenava

Product Type : Antibody

Upfront Cash : Inapplicable

January 16, 2025

Lead Product(s) : Bevacizumab

Therapeutic Area : Ophthalmology

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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