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Pharmaceuticals"},{"orgOrder":0,"company":"Eyconis","sponsor":"Ascendis Pharma","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Large molecule","year":"2024","type":"Licensing Agreement","leadProduct":"Ranibizumab","moa":"","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"Eyconis","amount2":0.25,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0.25,"dosageForm":"Injection","sponsorNew":"Eyconis \/ Ascendis Pharma","highestDevelopmentStatusID":"4","companyTruncated":"Eyconis \/ Ascendis Pharma"},{"orgOrder":0,"company":"Chromocell Corporation","sponsor":"Alliance Global Partners","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Public Offering","leadProduct":"CC8464","moa":"","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"Chromocell Corporation","amount2":0.01,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0.01,"dosageForm":"","sponsorNew":"Chromocell Corporation \/ Alliance Global Partners","highestDevelopmentStatusID":"4","companyTruncated":"Chromocell Corporation \/ Alliance Global Partners"},{"orgOrder":0,"company":"Trutag Technologies","sponsor":"Spinnaker Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Large molecule","year":"2023","type":"Partnership","leadProduct":"Silicon Oxide Loaded Ranibizumab","moa":"","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"Trutag Technologies","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Trutag Technologies \/ Spinnaker Biosciences","highestDevelopmentStatusID":"4","companyTruncated":"Trutag Technologies \/ Spinnaker Biosciences"},{"orgOrder":0,"company":"Chromocell Corporation","sponsor":"Alliance Global Partners","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Public Offering","leadProduct":"CC8464","moa":"","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"Chromocell Corporation","amount2":0.01,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0.01,"dosageForm":"","sponsorNew":"Chromocell Corporation \/ Alliance Global Partners","highestDevelopmentStatusID":"4","companyTruncated":"Chromocell Corporation \/ Alliance Global Partners"},{"orgOrder":0,"company":"PulseSight Therapeutics","sponsor":"Pureos Bioventures","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"PST-809","moa":"","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"PulseSight Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"","sponsorNew":"PulseSight Therapeutics \/ Pureos Bioventures","highestDevelopmentStatusID":"4","companyTruncated":"PulseSight Therapeutics \/ Pureos Bioventures"},{"orgOrder":0,"company":"Oxurion","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"BELGIUM","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"Undisclosed","moa":"","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"Oxurion","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"","sponsorNew":"Oxurion \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Oxurion \/ Not Applicable"},{"orgOrder":0,"company":"Biophta","sponsor":"UI Investissement","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"Undisclosed","year":"2024","type":"Financing","leadProduct":"BO-001","moa":"","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"Biophta","amount2":0.01,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0.01,"dosageForm":"Insert","sponsorNew":"Biophta \/ UI Investissement","highestDevelopmentStatusID":"4","companyTruncated":"Biophta \/ UI Investissement"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : RevOpsis will integrate the CHO Edge System in the development and commercialization of its first-in-class fully modular tri-specific biologic, RO-104, for the treatment of retinal vascular diseases.

                          Brand Name : RO-104

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          November 19, 2024

                          Lead Product(s) : RO-104

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : RevOpsis Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          02

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The partnership aims to test investigational ocular surface immunoglobulin (OSIG) eye drops for their ability to treat ocular damage from sulfur mustard exposure.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 22, 2024

                          Lead Product(s) : OSIG-based Therapy

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : BARDA

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          03

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : SPG302 is a once-a-day pill being developed as a regenerative treatment, which is being evaluated for the treatment of patients with glaucoma.

                          Brand Name : SPG302

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 16, 2024

                          Lead Product(s) : SPG302

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The SBIR grant will fund critical R&D activities, including multidose GMP toxicology studies in nonhuman primates for RO-104, a first-in-class fully human modular tri-specific biologic.

                          Brand Name : RO-104

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 15, 2024

                          Lead Product(s) : RO-104

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : National Eye Institute

                          Deal Size : $1.8 million

                          Deal Type : Funding

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                          05

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Surrozen collaborates with Boehringer to research & develop SZN-413 to treat retinal diseases and will receive an exclusive, worldwide license to develop other Fzd4-specific Wnt-modulating molecules.

                          Brand Name : SZN-413

                          Molecule Type : Large molecule

                          Upfront Cash : $12.5 million

                          September 24, 2024

                          Lead Product(s) : SZN-413

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Boehringer Ingelheim GmbH

                          Deal Size : $599.0 million

                          Deal Type : Collaboration

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                          06

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Under the license agreement, Glaukos will fund and conduct NCX 1728 preclinical research activities evaluating it in glaucoma (including neuroprotection) and other retinal diseases.

                          Brand Name : NCX 1728

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 23, 2024

                          Lead Product(s) : NCX 1728

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Glaukos

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          07

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : PAS-nomacopan is a long-acting bispecific inhibitor of C5 and leukotriene B4 (LTB4) product candidate for intravitreal treatment of geographic atrophy (GA).

                          Brand Name : rVA576

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 19, 2024

                          Lead Product(s) : PAS-Nomacopan

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : NOX-E36 (emapticap pegol) is an injectable PEGylated L-stereoisomer RNA aptamer that inhibits chemokine CCL2 and is in preclinical studies for early glaucoma treatment.

                          Brand Name : NOX-E36

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 22, 2024

                          Lead Product(s) : Emapticap pegol

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : ExoPTEN comprises exosomes loaded with siRNA that inhibits the production of the PTEN protein. It is being evaluated for glaucoma.

                          Brand Name : ExoPTEN

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 17, 2024

                          Lead Product(s) : ExoPTEN

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Under the terms of the agreement, Beacon will be responsible for the development and commercialization of AAV204 capsid for potential use for the treatment of retinal diseases.

                          Brand Name : AAV204

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          July 11, 2024

                          Lead Product(s) : AAV204

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Beacon Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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