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    [{"orgOrder":0,"company":"OPKO Health","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2021","type":"Inapplicable","leadProduct":"Calcifediol","moa":"Vitamin D3 receptor","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"OPKO Health \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OPKO Health \/ Inapplicable"},{"orgOrder":0,"company":"OPKO Health","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2021","type":"Inapplicable","leadProduct":"Calcifediol","moa":"Vitamin D3 receptor","graph1":"Infections and 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Inapplicable"},{"orgOrder":0,"company":"OPKO Health","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2020","type":"Inapplicable","leadProduct":"Calcifediol","moa":"Vitamin D3 receptor","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"OPKO Health \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"OPKO Health \/ Inapplicable"},{"orgOrder":0,"company":"OPKO Health","sponsor":"VFMCRP","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2022","type":"Inapplicable","leadProduct":"Calcifediol","moa":"Vitamin D3 receptor","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"OPKO Health \/ VFMCRP","highestDevelopmentStatusID":"15","companyTruncated":"OPKO Health \/ VFMCRP"},{"orgOrder":0,"company":"OPKO Health","sponsor":"Vifor Pharma","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2021","type":"Termination","leadProduct":"Calcifediol","moa":"Vitamin D3 receptor","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"OPKO Health \/ Vifor Pharma","highestDevelopmentStatusID":"15","companyTruncated":"OPKO Health \/ Vifor Pharma"},{"orgOrder":0,"company":"OPKO Health","sponsor":"HealthCare Royalty","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Other Large Molecule","year":"2024","type":"Agreement","leadProduct":"Somatrogon","moa":"STAT5b signalling pathway","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"OPKO Health \/ HealthCare Royalty","highestDevelopmentStatusID":"15","companyTruncated":"OPKO Health \/ HealthCare Royalty"},{"orgOrder":0,"company":"OPKO Health","sponsor":"Pfizer Inc","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Other Large Molecule","year":"2020","type":"Inapplicable","leadProduct":"Somatrogon","moa":"STAT5b signalling pathway","graph1":"Endocrinology","graph2":"Approved FDF","graph3":"OPKO 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Health","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"OPKO Health \/ Pfizer Inc","highestDevelopmentStatusID":"15","companyTruncated":"OPKO Health \/ Pfizer Inc"},{"orgOrder":0,"company":"ModeX Therapeutics","sponsor":"BARDA","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Undisclosed","year":"2023","type":"Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"ModeX Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Buccal","sponsorNew":"ModeX Therapeutics \/ BARDA","highestDevelopmentStatusID":"4","companyTruncated":"ModeX Therapeutics \/ BARDA"},{"orgOrder":0,"company":"ModeX Therapeutics","sponsor":"OPKO 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Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ModeX Therapeutics \/ BARDA","highestDevelopmentStatusID":"4","companyTruncated":"ModeX Therapeutics \/ BARDA"},{"orgOrder":0,"company":"OPKO Health","sponsor":"Leader Medical","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Peptide","year":"2021","type":"Agreement","leadProduct":"OPK88003","moa":"GLP-1 receptor","graph1":"Endocrinology","graph2":"Phase II","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"OPKO Health \/ Leader Medical","highestDevelopmentStatusID":"8","companyTruncated":"OPKO Health \/ Leader Medical"},{"orgOrder":0,"company":"OPKO Health","sponsor":"CAMP4 Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Undisclosed","year":"2021","type":"Licensing Agreement","leadProduct":"OPK88001","moa":"SCN1A","graph1":"Neurology","graph2":"Preclinical","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"OPKO Health \/ CAMP4 Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"OPKO Health \/ CAMP4 Therapeutics"},{"orgOrder":0,"company":"OPKO Health","sponsor":"Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2025","type":"Inapplicable","leadProduct":"V350A","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Phase I","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"OPKO Health \/ Merck & Co","highestDevelopmentStatusID":"6","companyTruncated":"OPKO Health \/ Merck & Co"},{"orgOrder":0,"company":"OPKO Health","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2023","type":"Collaboration","leadProduct":"MDX-2201","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"IND Enabling","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"OPKO Health \/ Merck & Co","highestDevelopmentStatusID":"5","companyTruncated":"OPKO Health \/ Merck & Co"},{"orgOrder":0,"company":"OPKO Health","sponsor":"EnteraBio Ltd","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Peptide","year":"2025","type":"Collaboration","leadProduct":"Oxyntomodulin Analog","moa":"GCGR\/GLP-1R","graph1":"Nutrition and Weight Loss","graph2":"Preclinical","graph3":"OPKO Health","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"OPKO Health \/ EnteraBio Ltd","highestDevelopmentStatusID":"4","companyTruncated":"OPKO Health \/ EnteraBio Ltd"}]

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                            01

                            OPKO Health

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                            OPKO Health

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                            Lead Product(s) : Oxyntomodulin Analog

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Preclinical

                            Sponsor : EnteraBio Ltd

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            OPKO Health, Entera Bio Partner on Oral Dual Agonist GLP-1

                            Details : The collaborations aims to advance the oral dual agonist GLP-1/glucagon peptide OPK-88006 (oxyntomodulin analog) as a once-daily tablet treatment for patients with obesity.

                            Product Name : OPK-88006

                            Product Type : Peptide

                            Upfront Cash : Undisclosed

                            March 19, 2025

                            Lead Product(s) : Oxyntomodulin Analog

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Preclinical

                            Sponsor : EnteraBio Ltd

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            02

                            OPKO Health

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                            OPKO Health

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                            Lead Product(s) : V350A

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            OPKO Health’s ModeX Announces Epstein-Barr Virus Vaccine in Phase I Study

                            Details : V350A is a vaccine candidate based on MDX2201 ferritin nanoparticle vaccine platform, being investigated for the treatment of epstein-barr virus infection.

                            Product Name : V350A

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            January 07, 2025

                            Lead Product(s) : V350A

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            OPKO Health

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                            OPKO Health

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                            Lead Product(s) : Somatrogon

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : HealthCare Royalty

                            Deal Size : $250.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            OPKO and HealthCare Royalty Enter $250M Note Purchase Agreement Secured by NGENLA Payments

                            Details : OPKO retained a significant portion of Ngenla (somatrogon) through the agreement. It is an approved product, which is indicated for pediatric patients with growth hormone deficiency.

                            Product Name : Ngenla

                            Product Type : Other Large Molecule

                            Upfront Cash : Undisclosed

                            July 17, 2024

                            Lead Product(s) : Somatrogon

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : HealthCare Royalty

                            Deal Size : $250.0 million

                            Deal Type : Agreement

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                            04

                            ModeX Therapeutics

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                            MAGHREB PHARMA
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                            ModeX Therapeutics

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                            MAGHREB PHARMA
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                            Lead Product(s) : MDX2202

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : BARDA

                            Deal Size : $110.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            ModeX Secures $35M For COVID Antibodies, $16M For Influenza Program

                            Details : The funding will support the development of a novel multispecific antibody to SARS-CoV-2 from preclinical and influenza multispecifics with gene and/or protein delivery modalities.

                            Product Name : MDX2202

                            Product Type : Other Large Molecule

                            Upfront Cash : Undisclosed

                            July 10, 2024

                            Lead Product(s) : MDX2202

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : BARDA

                            Deal Size : $110.0 million

                            Deal Type : Funding

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                            05

                            ModeX Therapeutics

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                            MAGHREB PHARMA
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                            ModeX Therapeutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Discovery

                            Sponsor : BARDA

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            ModeX Therapeutics Secures BARDA Contract to Develop Novel Multispecific Antibodies Against Viral Infectious D...

                            Details : The agreement aims to advance a platform and specific candidates addressing a range of viral infectious diseases and will enable research, development and clinical evaluation of potent multispecific antibodies, based on ModeX proprietary MSTAR technology...

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            September 28, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Discovery

                            Sponsor : BARDA

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            06

                            OPKO Health

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                            OPKO Health

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                            Lead Product(s) : MDX-2201

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : IND Enabling

                            Sponsor : Merck & Co

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            OPKO Health's ModeX Therapeutics Enters into Exclusive Worldwide License and Collaboration Agreement with Merc...

                            Details : ModeX and Merck will jointly advance MDX-2201 to an IND application filing, after which Merck will be responsible for clinical and regulatory activities and product commercialization. MDX-2201 leverages ModeX’s innovative biologics platform to target m...

                            Product Name : MDX-2201

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            August 03, 2023

                            Lead Product(s) : MDX-2201

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : IND Enabling

                            Sponsor : Merck & Co

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

                            ModeX Therapeutics

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                            MAGHREB PHARMA
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                            ModeX Therapeutics

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                            MAGHREB PHARMA
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : OPKO Health

                            Deal Size : $300.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            OPKO Health Acquires ModeX Therapeutics, Gains Proprietary Immunotherapy Technology with a Focus on Oncology a...

                            Details : ModeX Therapeutics has developed highly flexible multi-specific antibody technology platforms with broad targeting and functional capabilities, simpler manufacturing and potentially better specificity and safety, providing significant differentiation fro...

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            September 05, 2022

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : OPKO Health

                            Deal Size : $300.0 million

                            Deal Type : Acquisition

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                            08

                            OPKO Health

                            U.S.A arrow
                            MAGHREB PHARMA
                            Not Confirmed

                            OPKO Health

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                            MAGHREB PHARMA
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                            Lead Product(s) : Calcifediol

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved FDF

                            Sponsor : VFMCRP

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAYALDEE® Launched in Germany by OPKO Health’s Licensee, VFMCRP

                            Details : RAYALDEE extended-release capsules are indicated for the treatment of secondary hyperparathyroidism (SHPT) in adult patients with stage 3 or 4 chronic kidney disease (CKD) and vitamin D insufficiency.

                            Product Name : Rayaldee

                            Product Type : Vitamins/Minerals/Inorganic Salts

                            Upfront Cash : Inapplicable

                            March 02, 2022

                            Lead Product(s) : Calcifediol

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved FDF

                            Sponsor : VFMCRP

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            OPKO Health

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                            MAGHREB PHARMA
                            Not Confirmed

                            OPKO Health

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                            MAGHREB PHARMA
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                            Lead Product(s) : OPK88001

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : CAMP4 Therapeutics

                            Deal Size : $93.5 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            OPKO Health Licenses Oligonucleotide Therapeutics Platform to CAMP4 Therapeutics

                            Details : CAMP4 is pioneering a novel approach to programmable therapeutics that combines a deep understanding of regulatory RNA and gene expression with a complementary and customizable oligonucleotide modality.

                            Product Name : OPK88001

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            December 07, 2021

                            Lead Product(s) : OPK88001

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : CAMP4 Therapeutics

                            Deal Size : $93.5 million

                            Deal Type : Licensing Agreement

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                            10

                            OPKO Health

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                            MAGHREB PHARMA
                            Not Confirmed

                            OPKO Health

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                            MAGHREB PHARMA
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                            Lead Product(s) : Somatrogon

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase III

                            Sponsor : Pfizer Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pfizer and Opko Announce Extension of U.S. FDA Review of Biologics License Application of Somatrogon for Pedia...

                            Details : Somatrogon is an investigational biologic product that is glycosylated and comprises amino acid sequence of human growth hormone and one copy of C-terminal peptide from beta chain used for treatment of growth hormone deficiency (GHD) in pediatric patient...

                            Product Name : Ngenla

                            Product Type : Other Large Molecule

                            Upfront Cash : Inapplicable

                            September 24, 2021

                            Lead Product(s) : Somatrogon

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase III

                            Sponsor : Pfizer Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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