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II","graph3":"ORIC Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"ORIC Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"ORIC Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"ORIC Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"ORIC-114","moa":"EGFR","graph1":"Oncology","graph2":"Preclinical","graph3":"ORIC Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"ORIC Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"ORIC Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"ORIC Pharmaceuticals","sponsor":"Not 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Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"ORIC Pharmaceuticals \/ ORIC Pharmaceuticals","highestDevelopmentStatusID":"14","companyTruncated":"ORIC Pharmaceuticals \/ ORIC Pharmaceuticals"}]

Find Clinical Drug Pipeline Developments & Deals by ORIC Pharmaceuticals

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : The collaboration aims to leverage OpenBench's approach for early drug discovery against an undisclosed target identified by ORIC's resistance platform, focusing on cancer-specific vulnerabilities.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 17, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Recipient : OpenBench

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          02

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : The collaboration with Bayer and J&J will assist in advancing ORIC-944, PRC2 inhibitor, which will be evaluated in combination with darolutamide and apalutamide in patients with mCRPC.

                          Brand Name : ORIC-944

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 16, 2024

                          Lead Product(s) : ORIC-944

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Bayer AG

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          03

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : Net proceeds will fund research and development of ORIC-533, a small molecule inhibitor of CD73, targeting chemotherapy and immunotherapy resistance.

                          Brand Name : ORIC-533

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          January 22, 2024

                          Lead Product(s) : ORIC-533

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Viking Global Investors

                          Deal Size : $125.0 million

                          Deal Type : Private Placement

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                          04

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : ORIC-944 is a potent and selective allosteric inhibitor of PRC2. It is under phase 1 clinical development for the treatment of metastatic prostate cancer.

                          Brand Name : ORIC-944

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 08, 2024

                          Lead Product(s) : ORIC-944

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : ORIC-533 is a highly potent, orally bioavailable small molecule inhibitor of CD73. It is being evaluated under Phase 1 clinical development for the treatment of patients with relapsed/refractory multiple myeloma.

                          Brand Name : ORIC-533

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 11, 2023

                          Lead Product(s) : ORIC-533

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : ORIC-114 is a highly selective, brain penetrant, orally bioavailable, irreversible inhibitor designed to selectively target EGFR and HER2 with high potency against exon 20 insertion mutations non-small cell lung cancer.

                          Brand Name : ORIC-114

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 21, 2023

                          Lead Product(s) : ORIC-114

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : The net proceeds will be used to fund the development of ORIC-114, a brain penetrant inhibitor designed to selectively target EGFR and HER2 with high potency against exon 20 insertion mutations, being developed across multiple genetically defined cancers...

                          Brand Name : ORIC-114

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 26, 2023

                          Lead Product(s) : ORIC-114

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Nextech

                          Deal Size : $85.0 million

                          Deal Type : Private Placement

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                          08

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : ORIC-533, is an orally bioavailable small molecule inhibitor of CD73 that has demonstrated more potent adenosine inhibition in vitro compared to an antibody-based approach, and single agent activity in myeloma model systems.

                          Brand Name : ORIC-533

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 21, 2022

                          Lead Product(s) : ORIC-533,Elranatamab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Pfizer Inc

                          Deal Size : $25.0 million

                          Deal Type : Collaboration

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                          09

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : ORIC-533 is a highly potent, orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy and immunotherapy-based treatment regimens.

                          Brand Name : ORIC-533

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 13, 2022

                          Lead Product(s) : ORIC-533

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : In autologous ex vivo assays using bone marrow aspirates from patients with relapsed refractory multiple myeloma, ORIC-533 overcame immune suppression and triggered significant lysis of multiple myeloma cells across all dose levels tested and in a dose-r...

                          Brand Name : ORIC-533

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 03, 2022

                          Lead Product(s) : ORIC-533

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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