[{"orgOrder":0,"company":"Orna Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Not Applicable","leadProduct":"ORN-101","moa":"CD19","graph1":"Oncology","graph2":"Preclinical","graph3":"Orna Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Orna Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Orna Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Orna Therapeutics","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2022","type":"Collaboration","leadProduct":"Circular RNA-based Vaccine","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Discovery Platform","graph3":"Orna Therapeutics","amount2":3.6499999999999999,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Infectious Diseases","amount2New":3.6499999999999999,"dosageForm":"","sponsorNew":"Orna Therapeutics \/ Merck & Co. Inc.","highestDevelopmentStatusID":"3","companyTruncated":"Orna Therapeutics \/ Merck & Co. Inc."},{"orgOrder":0,"company":"Orna Therapeutics","sponsor":"Vertex Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Hematology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Hematology","graph2":"Discovery","graph3":"Orna Therapeutics","amount2":0.69999999999999996,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Hematology","amount2New":0.69999999999999996,"dosageForm":"","sponsorNew":"Orna Therapeutics \/ Vertex Pharmaceuticals","highestDevelopmentStatusID":"2","companyTruncated":"Orna Therapeutics \/ Vertex Pharmaceuticals"}]

Find Clinical Drug Pipeline Developments & Deals by Orna Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : Through the collaboration, Vertex will utilize Orna's proprietary LNP delivery solutions to enhance it's efforts in developing next-gen gene editing therapies for patients with SCD and TDT.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $65.0 million

                          January 07, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Hematology

                          Highest Development Status : Discovery

                          Sponsor : Vertex Pharmaceuticals

                          Deal Size : $700.0 million

                          Deal Type : Collaboration

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                          02

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : Under the agreement, Merck will discover, develop, and commercialize multiple programs, including vaccines and therapeutics in the areas of infectious disease and oncology by using Orna’s proprietary oRNA technology.

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : $150.0 million

                          August 16, 2022

                          Lead Product(s) : Circular RNA-based Vaccine

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Discovery Platform

                          Sponsor : Merck & Co

                          Deal Size : $3,650.0 million

                          Deal Type : Collaboration

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                          03

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : First in vivo studies for ORN-101, demonstrated the potential of Orna's circular RNA (oRNA™) platform in cancer, genetic disorders, and infectious diseases.

                          Product Name : ORN-101

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 02, 2022

                          Lead Product(s) : ORN-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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