[{"orgOrder":0,"company":"Locate Bio","sponsor":"Mercia Ventures","pharmaFlowCategory":"D","therapeuticArea":"Orthopedics\/Orthopedic Surgery","country":"UNITED KINGDOM","productType":"Large molecule","year":"2024","type":"Funding","leadProduct":"rhBMP-2","moa":"","graph1":"Orthopedics\/Orthopedic Surgery","graph2":"Preclinical","graph3":"Locate Bio","amount2":0.01,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Orthopedics","amount2New":0.01,"dosageForm":"","sponsorNew":"Locate Bio \/ Mercia Ventures","highestDevelopmentStatusID":"4","companyTruncated":"Locate Bio \/ Mercia Ventures"},{"orgOrder":0,"company":"Astellas Pharma","sponsor":"Osaka University","pharmaFlowCategory":"D","therapeuticArea":"Orthopedics\/Orthopedic Surgery","country":"JAPAN","productType":"Cell and Gene therapy","year":"2024","type":"Collaboration","leadProduct":"Pluripotent Stem Cell-derived Therapy","moa":"","graph1":"Orthopedics\/Orthopedic Surgery","graph2":"Preclinical","graph3":"Astellas Pharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Orthopedics","amount2New":0,"dosageForm":"","sponsorNew":"Astellas Pharma \/ Osaka University","highestDevelopmentStatusID":"4","companyTruncated":"Astellas Pharma \/ Osaka University"},{"orgOrder":0,"company":"Redwire Corporation","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"D","therapeuticArea":"Orthopedics\/Orthopedic Surgery","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Partnership","leadProduct":"ELP-004","moa":"","graph1":"Orthopedics\/Orthopedic Surgery","graph2":"Preclinical","graph3":"Redwire Corporation","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Orthopedics","amount2New":0,"dosageForm":"","sponsorNew":"Redwire Corporation \/ Bristol Myers Squibb","highestDevelopmentStatusID":"4","companyTruncated":"Redwire Corporation \/ Bristol Myers Squibb"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Redwire Corporation

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                          PharmaVenue
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                          Redwire Corporation

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                          Details : The partnership aims to study model small molecule compounds, including ELP-004, using Redwire’s pharmaceutical drug development platform (PIL-BOX).

                          Brand Name : ELP-004

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 23, 2024

                          Lead Product(s) : ELP-004

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Preclinical

                          Sponsor : Bristol Myers Squibb

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          02

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : The collaboration aims to develop innovative pluripotent stem cell-derived cartilage organoid cell therapy for the treatment of intervertebral disc degenerative disease.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          July 22, 2024

                          Lead Product(s) : Pluripotent Stem Cell-derived Therapy

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Preclinical

                          Sponsor : Osaka University

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          03

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : LDGraft (rhBMP-2) by Locate Bio is undergoing early clinical trials for treating degenerative disc disease.

                          Brand Name : LDGraft

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 29, 2024

                          Lead Product(s) : rhBMP-2

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Preclinical

                          Sponsor : Mercia Ventures

                          Deal Size : $9.8 million

                          Deal Type : Funding

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