10
ALL3
Acousia Therapeutics1
Autifony Therapeutics1
Cilcare3
Decibel Therapeutics1
Frequency Therapeutics1
Spiral TherapeuticsYear
10
ALL1
20241
20235
20223
2020DEALS // DEV.
10
ALL3
Deals7
DevelopmentsCountry
10
ALL1
FRANCE3
GERMANY5
U.S.A1
UNITED KINGDOM10
ALL1
Boehringer Ingelheim GmbH7
Inapplicable1
Savoir Capital1
ShionogiTherapeutic Area
10
ALL10
Otolaryngology (Ear, Nose, Throat)Study Phase
10
ALL10
Phase IDeal Type
10
ALL1
Agreement1
Financing7
Inapplicable1
TerminationProduct Type
10
ALL7
Other Small Molecule3
Vitamins/Minerals/Inorganic SaltsDosage Form
10
ALL2
Intratympanic Injection3
Intravenous Injection5
UndisclosedLead Product
10
ALL3
ACOU0851
AUT002061
CIL0011
FX-3451
SPT-21013
Sodium ThiosulfateTarget
10
ALL1
GSK-33
KCNQ potassium channel1
KV3 potassium ion channel3
Platinum/protein complex2
UndisclosedLead Product(s) : CIL001
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Shionogi
Deal Size : $16.0 million
Deal Type : Agreement
Japan's Shionogi Inks €400 M Deal with French Firm Cilcare
Details : Through the agreement with Cilcare to acquire the exclusive license to develop, manufacture, and commercialize CIL001 for the treatment of patients with hearing loss.
Product Name : CIL001
Product Type : Other Small Molecule
Upfront Cash : $16.0 million
October 06, 2024
Lead Product(s) : CIL001
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Shionogi
Deal Size : $16.0 million
Deal Type : Agreement
Lead Product(s) : SPT-2101
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Savoir Capital
Deal Size : $8.2 million
Deal Type : Financing
Spiral Therapeutics Completes $8.25M Financing and Initiates Phase 2 Trial in Meniere's Disease
Details : SPT-2101 is a sustained-release steroid formulation designed for precise inner ear administration using Spiral's novel delivery procedure. Spiral recently completed enrollment of an open label pilot clinical study of SPT-2101 in 10 patients with Meniere'...
Product Name : SPT-2101
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
October 01, 2023
Lead Product(s) : SPT-2101
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Savoir Capital
Deal Size : $8.2 million
Deal Type : Financing
Lead Product(s) : FX-345
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : FX-345 is a combination of two small molecules and, similar to Frequency’s lead hearing candidate FX-322, is designed to restore inner ear cells needed for hearing.
Product Name : FX-345
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 15, 2022
Lead Product(s) : FX-345
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ACOU085
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ACOU085 is a proprietary small molecule, etiology-agnostic otoprotective drug candidate, expected to finish a first-in-man clinical Phase 1b study by late 2022 using standard transtympanic administration of a slow-release gel formulation.
Product Name : ACOU085
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 24, 2022
Lead Product(s) : ACOU085
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ACOU085
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ACOU085 is a proprietary, first-in-class, small-molecule otoprotective drug candidate, which is currently being tested in a Phase 1b clinical trial involving age-related hearing loss (ARHL) patients.
Product Name : ACOU085
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 05, 2022
Lead Product(s) : ACOU085
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : R-Azasetron Besylate
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SENS-401 (R-azasetron Besylate) is a drug candidate that aims to protect and preserve inner ear tissue from damage that can cause progressive or sequelar hearing impairment.
Product Name : SENS-401
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 06, 2022
Lead Product(s) : R-Azasetron Besylate
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sodium Thiosulfate
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : 87% of patients who experienced ototoxicity in their placebo-treated ear were protected from ototoxicity in their DB-020, a novel, proprietary formulation of sodium thiosulfate treated ear.
Product Name : DB-020
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
June 28, 2022
Lead Product(s) : Sodium Thiosulfate
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ACOU085
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ACOU085 is a proprietary small-molecule, otoprotective drug candidate that modulates a well-defined molecular target preferentially expressed in the sensory cells of the inner ear, the so-called outer hair cells (OHC).
Product Name : ACOU085
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
May 05, 2022
Lead Product(s) : ACOU085
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : AUT00206
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Boehringer Ingelheim GmbH
Deal Size : $50.1 million
Deal Type : Termination
Autifony Therapeutics Regains Rights to Clinical Stage Kv3 Programme
Details : Boehringer Ingelheim will not be exercising its Option under the Option for Asset Purchase Agreement which was signed by the two companies in December 2017. Autifony has regained full rights to its Kv3 programme.
Product Name : AUT00206
Product Type : Other Small Molecule
Upfront Cash : $29.5 million
August 26, 2020
Lead Product(s) : AUT00206
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Boehringer Ingelheim GmbH
Deal Size : $50.1 million
Deal Type : Termination
Lead Product(s) : Sodium Thiosulfate
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The Phase 1a trial showed that DB-020 was safe and well-tolerated in healthy volunteers and confirmed that administration of DB-020.
Product Name : DB-020
Product Type : Vitamins/Minerals/Inorganic Salts
Upfront Cash : Inapplicable
March 26, 2020
Lead Product(s) : Sodium Thiosulfate
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable