Lead Product(s) : OTOF-GT
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : Sensorion
Deal Size : Undisclosed
Deal Type : Agreement
Sensorion and Novasep Sign Agreement
Details : The agreement aims for the manufacturing of adeno-associated virus (AAV) vectors, covering the gene therapy program targeting OTOF (OTOF-GT), the gene encoding the otoferlin protein and aims to restore the expression of Otoferlin.
Brand Name : OTOF-GT
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
March 11, 2020
Lead Product(s) : OTOF-GT
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : Sensorion
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : SENS-501
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : Institut Pasteur
Deal Size : Undisclosed
Deal Type : Partnership
Sensorion Extends Partnership with Institut Pasteur for Hearing Disorder Gene Therapies
Details : Sensorion and Institut Pasteur are developing gene therapies, including SENS-501 for otoferlin-related deafness and GJB2-GT for GJB2 mutation-related hearing loss.
Brand Name : OTOF-GT
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
January 05, 2024
Lead Product(s) : SENS-501
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : Institut Pasteur
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Nanoparticle-formulated Peptide Solution
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : NMIN
Deal Size : $0.1 million
Deal Type : Funding
Details : The funds will be used to establish pre-clinical toxicology parameters of the peptide technology and determine the pharmacokinetic and pharmacodynamic properties of the nanoparticle-formulated peptide solution when delivered intranasally to guide dosing ...
Brand Name : Undisclosed
Molecule Type : Peptide
Upfront Cash : Undisclosed
June 23, 2023
Lead Product(s) : Nanoparticle-formulated Peptide Solution
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : NMIN
Deal Size : $0.1 million
Deal Type : Funding
Lead Product(s) : SENS-501
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SENS-501 is an adeno-associated vector-based gene therapy for the autosomal recessive non-syndromic Deafness 9. It is being investigated in preclinical stage for DFNB9.
Brand Name : SENS-501
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
February 02, 2023
Lead Product(s) : SENS-501
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : OTOF-GT
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : OTOF-GT is targeting deafness caused by a mutation of the gene encoding for otoferlin, and hearing loss related to mutation in GJB2 gene to potentially address important hearing loss segments in adults and children (GJB2-GT).
Brand Name : OTOF-GT
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
October 06, 2022
Lead Product(s) : OTOF-GT
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : KRM-II-81
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : National Institutes on Drug Abuse
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : KRM-II-81 has a preclinical profile predicting efficacy against pharmacoresistant epilepsies, traumatic brain injury, and neuropathic pain. KRM-II-81 also produces anxiolytic- and antidepressant-like effects in rodent models.
Brand Name : KRM-II-81
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 16, 2022
Lead Product(s) : KRM-II-81
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : National Institutes on Drug Abuse
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : DB-OTO
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Podium presentation at ARO annual midwinter meeting highlighting DB-OTO, gene therapy cell-selective promoter to control otoferlin transgene expression in hair cells, dose-ranging studies with expression analysis, functional recovery, and tolerability da...
Brand Name : DB-OTO
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
February 09, 2022
Lead Product(s) : DB-OTO
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : DB-OTO
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Decibel Therapeutics Receives Orphan Drug and Rare Pediatric Disease Designations for DB-OTO
Details : DB-OTO is a dual-vector adeno-associated virus (AAV) investigational gene therapy product candidate designed to restore hearing to individuals with profound, congenital hearing loss caused by mutations in the otoferlin gene.
Brand Name : DB-OTO
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
September 09, 2021
Lead Product(s) : DB-OTO
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Stem cell therapy
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : Innovate UK
Deal Size : $4.5 million
Deal Type : Funding
Details : This grant will fund a £3.2 million project to further develop Rinri’s novel stem cell therapy to reverse sensorineural hearing loss (SNHL) an area / a condition where there remains a significant global unmet need.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
May 13, 2021
Lead Product(s) : Stem cell therapy
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : Innovate UK
Deal Size : $4.5 million
Deal Type : Funding
Lead Product(s) : Stem cell therapy
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : Preclinical
Sponsor : Boehringer Ingelheim GmbH
Deal Size : $14.1 million
Deal Type : Financing
Details : The proceeds will support the development of the Company's novel stem cell therapy to reverse sensorineural hearing loss (SNHL).
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
April 20, 2021
Lead Product(s) : Stem cell therapy
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : Preclinical
Sponsor : Boehringer Ingelheim GmbH
Deal Size : $14.1 million
Deal Type : Financing
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