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Pharmaceutical","highestDevelopmentStatusID":"12","companyTruncated":"Otsuka Pharmaceutical \/ Otsuka Pharmaceutical"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"JAPAN","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Brexpiprazole","moa":"","graph1":"Neurology","graph2":"Approved","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Otsuka Pharmaceutical \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Otsuka Pharmaceutical \/ Not Applicable"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"JAPAN","productType":"Small molecule","year":"2023","type":"Not 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Pharmaceutical \/ Otsuka Pharmaceutical","highestDevelopmentStatusID":"12","companyTruncated":"Otsuka Pharmaceutical \/ Otsuka Pharmaceutical"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"JAPAN","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Sibeprenlimab","moa":"","graph1":"Nephrology","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Otsuka Pharmaceutical \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ Not Applicable"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"H. Lundbeck AS","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"JAPAN","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Brexpiprazole","moa":"","graph1":"Psychiatry\/Psychology","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Otsuka Pharmaceutical \/ H. Lundbeck AS","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ H. Lundbeck AS"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"H. Lundbeck AS","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"JAPAN","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Brexpiprazole","moa":"","graph1":"Psychiatry\/Psychology","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Otsuka Pharmaceutical \/ H. Lundbeck AS","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ H. Lundbeck AS"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Ionis Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2024","type":"Licensing Agreement","leadProduct":"Donidalorsen","moa":"","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"","sponsorNew":"Otsuka Pharmaceutical \/ Otsuka Pharmaceutical","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ Otsuka Pharmaceutical"},{"orgOrder":0,"company":"Otsuka Holdings","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"JAPAN","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Deudextromethorphan Hydrobromide","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"Otsuka Holdings","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"Otsuka Holdings \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Holdings \/ Not Applicable"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"H. Lundbeck AS","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"JAPAN","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Brexpiprazole","moa":"","graph1":"Psychiatry\/Psychology","graph2":"Phase III","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"","sponsorNew":"Otsuka Pharmaceutical \/ H. Lundbeck AS","highestDevelopmentStatusID":"10","companyTruncated":"Otsuka Pharmaceutical \/ H. Lundbeck AS"},{"orgOrder":0,"company":"Taiho Pharmaceutical","sponsor":"Arcus Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Licensing Agreement","leadProduct":"Quemliclustat","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Taiho Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Taiho Pharmaceutical \/ Taiho Pharmaceutical","highestDevelopmentStatusID":"12","companyTruncated":"Taiho Pharmaceutical \/ Taiho Pharmaceutical"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Jnana Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Acquisition","leadProduct":"JNT-517","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Otsuka Pharmaceutical","amount2":1.1299999999999999,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Otsuka Pharmaceutical \/ Otsuka Pharmaceutical","highestDevelopmentStatusID":"12","companyTruncated":"Otsuka Pharmaceutical \/ Otsuka Pharmaceutical"},{"orgOrder":0,"company":"Taiho Pharmaceutical","sponsor":"Nuntius Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2024","type":"Collaboration","leadProduct":"mRNA-based Therapy","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Taiho Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Taiho Pharmaceutical \/ Taiho Pharmaceutical","highestDevelopmentStatusID":"12","companyTruncated":"Taiho Pharmaceutical \/ Taiho Pharmaceutical"},{"orgOrder":0,"company":"Otsuka Pharmaceutical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"JAPAN","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Sibeprenlimab","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Otsuka Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Otsuka Pharmaceutical \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Otsuka Pharmaceutical \/ Not Applicable"},{"orgOrder":0,"company":"Otsuka Holdings","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Sibeprenlimab","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Otsuka Holdings","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Otsuka Holdings \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Otsuka Holdings \/ Not Applicable"}]

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                            01

                            Otsuka Holdings

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                            Otsuka Holdings

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                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Otsuka Updates Sibeprenlimab Data for IgA Nephropathy Treatment in Adults

                            Details : VIS649 (sibeprenlimab) is an investigational humanized IgG2 monoclonal antibody that reduces Gd-IgA1 by binding to APRIL. It is being developed for Immunoglobulin A Nephropathy.

                            Brand Name : VIS649

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 19, 2024

                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Otsuka Pharmaceutical

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                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Otsuka Shows Positive Interim Results for Sibeprenlimab in IgA Nephropathy

                            Details : VIS649 (sibeprenlimab) is an investigational monoclonal antibody that blocks the action of APRIL (A PRoliferation-Inducing Ligand) for the treatment of immunoglobulin a nephropathy in adults.

                            Brand Name : VIS649

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 22, 2024

                            Lead Product(s) : Sibeprenlimab

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Taiho Pharmaceutical

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                            Lead Product(s) : mRNA-based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Undisclosed

                            Recipient : Nuntius Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Nuntius Partners with Taiho to Develop Next-Gen mRNA Therapies with Cell-Specific Tech

                            Details : Taiho will use Nuntius’ proprietary cell-specific delivery technology, peptide dendrimer- and lipid-based nanocarriers to develop novel mRNA cancer immunotherapies.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            August 15, 2024

                            Lead Product(s) : mRNA-based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Undisclosed

                            Recipient : Nuntius Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Otsuka Pharmaceutical

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                            Otsuka Pharmaceutical

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                            Lead Product(s) : JNT-517

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Recipient : Jnana Therapeutics

                            Deal Size : $1,125.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Japan's Otsuka Pharma to pay up to $1.1 bln to acquire Jnana Therapeutics

                            Details : Through the acquisition, Otsuka will leverage Jana pipelines, which include JNT-517 an allosteric small molecule inhibitor of SLC6A19. It is being evaluated for the treatment of phenylketonuria.

                            Brand Name : JNT-517

                            Molecule Type : Small molecule

                            Upfront Cash : $800.0 million

                            August 01, 2024

                            Lead Product(s) : JNT-517

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Recipient : Jnana Therapeutics

                            Deal Size : $1,125.0 million

                            Deal Type : Acquisition

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                            05

                            Taiho Pharmaceutical

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                            Taiho Pharmaceutical

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                            Lead Product(s) : Quemliclustat,Zimberelimab,Etrumadenant

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : Arcus Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Taiho Exercises License Option for Quemliclustat in Japan and Asia

                            Details : Under the license agreement, Taiho will further support the development & commercialization of AB680 (quemliclustat) & will operationalize the PRISM-1 study in Japan as part of its mission.

                            Brand Name : AB680

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            July 08, 2024

                            Lead Product(s) : Quemliclustat,Zimberelimab,Etrumadenant

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : Arcus Biosciences

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            06

                            Otsuka Pharmaceutical

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                            Lead Product(s) : Brexpiprazole,Sertraline Hydrochloride

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase III

                            Sponsor : H. Lundbeck AS

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Otsuka and Lundbeck Announce FDA Acceptance for Brexpiprazole in PTSD Treatment

                            Details : Rexulti (brexpiprazole) is an partial agonist of serotonin 5-HT1A, which is being investigated in combination therapy with sertraline for the treatment of post-traumatic stress disorder (PTSD).

                            Brand Name : Rexulti

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 25, 2024

                            Lead Product(s) : Brexpiprazole,Sertraline Hydrochloride

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase III

                            Sponsor : H. Lundbeck AS

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Otsuka Pharmaceutical

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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Donidalorsen

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Recipient : Ionis Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Ionis Expands Licensing Agreement with Otsuka for Donidalorsen in Hereditary Angioedema

                            Details : Ionis entered into a license agreement with Otsuka & obtained exclusive rights across the Asia-Pacific region for IONIS-PKK-LRx (donidalorsen) for treating hereditary angioedema.

                            Brand Name : IONIS-PKK-LRx

                            Molecule Type : Large molecule

                            Upfront Cash : $20.0 million

                            June 18, 2024

                            Lead Product(s) : Donidalorsen

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Recipient : Ionis Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            08

                            Otsuka Holdings

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                            Lead Product(s) : Deudextromethorphan Hydrobromide,Quinidine sulphate

                            Therapeutic Area : Neurology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Otsuka to Terminate Development of AVP-786

                            Details : Termination of development of the novel compound AVP-786 (deudextromethorphan HBr), in development for the treatment of agitation associated with dementia due to Alzheimer's.

                            Brand Name : AVP-786

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 22, 2024

                            Lead Product(s) : Deudextromethorphan Hydrobromide,Quinidine sulphate

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Otsuka Pharmaceutical

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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Brexpiprazole,Sertraline Hydrochloride

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase III

                            Sponsor : H. Lundbeck AS

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Otsuka and Lundbeck Submit sNDA for FDA Review of Brexpiprazole

                            Details : Rexulti (brexpiprazole) is an partial agonist activity at serotonin 5-HT1A, which is being investigated in combination therapy with sertraline for the treatment of post-traumatic stress disorder.

                            Brand Name : Rexulti

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 09, 2024

                            Lead Product(s) : Brexpiprazole,Sertraline Hydrochloride

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase III

                            Sponsor : H. Lundbeck AS

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Otsuka Pharmaceutical

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                            Lead Product(s) : Brexpiprazole,Sertraline Hydrochloride

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase III

                            Sponsor : H. Lundbeck AS

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Otsuka and Lundbeck Submit sNDA for FDA Review of Brexpiprazole and Sertraline Combination

                            Details : Rexulti (brexpiprazole) 5-HT2A receptor, is being evaluated in combination with sertraline in late-stage clinical trials with adult patients for the treatment of post-traumatic stress disorder.

                            Brand Name : Rexulti

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 09, 2024

                            Lead Product(s) : Brexpiprazole,Sertraline Hydrochloride

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase III

                            Sponsor : H. Lundbeck AS

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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