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                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Lytenava (bevacizumab) is a recombinant humanized mAb that selectively binds with high affinity to VEGF. It is indicated for the treatment of wet age-related macular degeneration.

                          Brand Name : Lytenava

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 27, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Lytenava (bevacizumab) is a recombinant humanized mAb that selectively binds with high affinity to VEGF. It is indicated for the treatment of wet age-related macular degeneration.

                          Brand Name : Lytenava

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 04, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : LYTENAVA (bevacizumab-vikg, bevacizumab gamma), an approved ophthalmic formulation developed as an intravitreal injection for wet AMD and other retinal diseases.

                          Brand Name : Lytenava

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 08, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ONS-5010/LYTENAVA™ becomes first ophthalmic formulation of bevacizumab to receive European Commission Marketing Authorization for the treatment of wet AMD.

                          Brand Name : Lytenava

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 28, 2024

                          Lead Product(s) : Bevacizumab Gamma

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Lytenava (bevacizumab) is a humanized monoclonal antibody binding to all isoforms of VEGF, under evaluation in phase 3 trials for wet age-related macular degeneration treatment.

                          Brand Name : Lytenava

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 13, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Outlook Therapeutics will use proceeds for ONS-5010/LYTENAVA (bevacizumab-vikg), an investigational formulation for intravitreal injection targeting wet AMD and other retinal diseases.

                          Brand Name : Lytenava

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 15, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Syntone Ventures

                          Deal Size : $5.0 million

                          Deal Type : Private Placement

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ONS-5010 (bevacizumab) is a monoclonal antibody binding human VEGF isoforms, under evaluation for treating wet age-related macular degeneration.

                          Brand Name : ONS-5010

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          March 22, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Outlook Therapeutics will use proceeds for ONS-5010/LYTENAVA (bevacizumab-vikg), an investigational formulation for intravitreal injection targeting wet AMD and other retinal diseases.

                          Brand Name : Lytenava

                          Molecule Type : Large molecule

                          Upfront Cash : $60.0 million

                          March 18, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : BofA Securities

                          Deal Size : $159.0 million

                          Deal Type : Private Placement

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ONS-5010 (bevacizumab-vikg) is a recombinant humanized monoclonal antibody selectively binding to all isoforms of VEGF, currently evaluated in Phase 3 trials for wet age-related macular degeneration.

                          Brand Name : ONS-5010

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 31, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Outlook Therapeutics will use proceeds for ONS-5010/Lytenava, an investigational bevacizumab formulation for wet AMD, including funding the NORSE EIGHT trial.

                          Brand Name : Lytenava

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 23, 2024

                          Lead Product(s) : Bevacizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Great Point Partners

                          Deal Size : $172.0 million

                          Deal Type : Private Placement

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