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[{"orgOrder":0,"company":"Overland Pharmaceuticals","sponsor":"Overland Pharmaceuticals","pharmaFlowCategory":"D","amount":"$50.0 million","upfrontCash":"Undisclosed","newsHeadline":"ADC Therapeutics and Overland Pharmaceuticals Announce Formation of Overland ADCT BioPharma","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"CHINA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"December 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"Overland Pharmaceuticals","sponsor":"ADC Therapeutics","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Overland ADCT BioPharma Announces First Patient Dosed in China with ZYNLONTA\u00ae in Combination with Rituximab in Global Phase 3 Clinical Trial","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"CHINA","productType":"Large molecule","productStatus":"Approved","date":"July 2022","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"Overland Pharmaceuticals","sponsor":"ADC Therapeutics","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Overland ADCT BioPharma Announces NMPA Accepts Biologics License Application and Grants Priority Review for ZYNLONTA\u00ae for Treatment of Relapsed or Refractory Diffuse Large B-cell Lymphoma","therapeuticArea":"Oncology","highestDevelopmentStatus":"Approved","country":"CHINA","productType":"Large molecule","productStatus":"Approved","date":"July 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Approved"}]

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            Zynlonta (loncastuximab tesirine-lpyl), an antibody-drug conjugate (ADC) targeting CD19, is approved by FDA and EU for the treatment of adult patients with relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

            Lead Product(s): Loncastuximab Tesirine

            Therapeutic Area: Oncology Product Name: Zynlonta

            Highest Development Status: Approved Product Type: Large molecule

            Recipient: ADC Therapeutics

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 24, 2023

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            ZYNLONTA® (loncastuximab tesirine-lpyl) is a CD19-directed antibody drug conjugate (ADC). Once bound to a CD19-expressing cell, ZYNLONTA is internalized by the cell, where enzymes release a pyrrolobenzodiazepine (PBD) payload.

            Lead Product(s): Loncastuximab Tesirine,Rituximab

            Therapeutic Area: Oncology Product Name: Zynlonta

            Highest Development Status: Phase III Product Type: Large molecule

            Recipient: ADC Therapeutics

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 11, 2022

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            ADC Therapeutics licensed exclusive development and commercialization rights to Lonca, ADCT-602, ADCT-601 and ADCT-901 for greater China and Singapore to Overland ADCT BioPharma. Overland Pharmaceuticals will have a 51% stake and ADC Therapeutics, 49%.

            Lead Product(s): Loncastuximab Tesirine,Rituximab

            Therapeutic Area: Oncology Product Name: Lonca

            Highest Development Status: Phase III Product Type: Large molecule

            Recipient: Overland ADCT BioPharma

            Deal Size: $50.0 million Upfront Cash: Undisclosed

            Deal Type: Agreement December 14, 2020

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