Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Ovid Therapeutics Presents Study Showing OV329 Doesn't Accumulate in Eyes
Details : OV329 is a next-generation GABA-aminotransferase (GABA-AT) inhibitor being developed as a potential medicine for rare and treatment-resistant forms of epilepsy and seizures.
Brand Name : OV329
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 26, 2024
Lead Product(s) : GV101
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Graviton Bioscience
Deal Size : Not Applicable
Deal Type : Not Applicable
Ovid and Graviton Announce Data for OV888/GV101 in Cerebral Cavernous Malformations
Details : OV888 (GV101) is an investigational small molecule capsule, works by inhibiting Rho-associated coiled-coil containing protein kinase 2 receptor for the treatment of cerebral cavernous malformations.
Brand Name : OV888
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 01, 2024
Lead Product(s) : GV101
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Graviton Bioscience
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Soticlestat
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Takeda Pharmaceutical
Deal Size : Not Applicable
Deal Type : Not Applicable
Ovid Therapeutics Reports Takeda’s Phase 3 Study Results for Soticlestat
Details : TAK-935 (soticlestat), an oral CH24H enzyme inhbitor, is being developed by Takeda in two Phase 3 trials for Lennox-Gastaut syndrome and Dravet syndrome.
Brand Name : TAK-935
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 17, 2024
Lead Product(s) : Soticlestat
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Takeda Pharmaceutical
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Soticlestat
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Ligand Pharmaceuticals
Deal Size : $30.0 million
Deal Type : Agreement
Details : Ligand has acquired a 13 percent portion of the royalties and milestones owed to Ovid related to the potential approval and commercialization of TAK-935 (soticlestat), being developed by Takeda in two Phase 3 trials for Lennox-Gastaut syndrome and Dravet...
Brand Name : TAK-935
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 18, 2023
Lead Product(s) : Soticlestat
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Ligand Pharmaceuticals
Deal Size : $30.0 million
Deal Type : Agreement
Lead Product(s) : GV101
Therapeutic Area : Neurology
Study Phase : Phase I
Recipient : Graviton Bioscience
Deal Size : $10.0 million
Deal Type : Collaboration
Details : The collaboration will advance clinical development of GV101, which is currently in a Phase 1 trial, along with other selective, small-molecule compounds from a library of ROCK2 inhibitors, that may penetrate the blood-brain barrier.
Brand Name : GV101
Molecule Type : Small molecule
Upfront Cash : $10.0 million
May 01, 2023
Lead Product(s) : GV101
Therapeutic Area : Neurology
Highest Development Status : Phase I
Recipient : Graviton Bioscience
Deal Size : $10.0 million
Deal Type : Collaboration
Ovid Therapeutics Dosed Healthy Volunteers with OV329 in Phase 1 Trial
Details : OV329 is a next-generation GABA-aminotransferase inhibitor being developed for the treatment of rare and treatment-resistant forms of epilepsy and seizures, such as seizures associated with tuberous sclerosis complex, infantile spasms, and conditions wit...
Brand Name : OV329
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 05, 2023
Lead Product(s) : OV329
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Ovid Therapeutics Presents Preclinical Data on OV329 at the Epilepsy Foundation Pipeline Conference
Details : OV329,, a next-generation GABA-aminotransferase (GABA-AT) inhibitor demonstrated robust anti-seizure activity in multiple preclinical seizure and epilepsy models, including treatment-resistant seizures.
Brand Name : OV329
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 06, 2022
Lead Product(s) : OV329
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : OV350
Therapeutic Area : Neurology
Study Phase : Preclinical
Recipient : AstraZeneca
Deal Size : $215.5 million
Deal Type : Collaboration
Ovid Therapeutics Expands Epilepsy Franchise with Novel KCC2 Activators
Details : The company seeks to optimize and accelerate development of these KCC2 transporter activators in epilepsies and potentially other neuropathic conditions such as OV350, could become a powerful weapon for clinicians seeking to treat a potential underlying ...
Brand Name : OV350
Molecule Type : Small molecule
Upfront Cash : $12.5 million
January 03, 2022
Lead Product(s) : OV350
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Recipient : AstraZeneca
Deal Size : $215.5 million
Deal Type : Collaboration
Lead Product(s) : Soticlestat
Therapeutic Area : Neurology
Study Phase : Phase II
Sponsor : Takeda Pharmaceutical
Deal Size : $856.0 million
Deal Type : Termination
Details : Takeda Pharmaceutical secured global rights from Ovid to develop and commercialize the investigational medicine soticlestat (TAK-935/OV935) for the treatment of developmental and epileptic encephalopathies, including Dravet syndrome and Lennox-Gastaut sy...
Brand Name : TAK-935
Molecule Type : Small molecule
Upfront Cash : $196.0 million
March 30, 2021
Lead Product(s) : Soticlestat
Therapeutic Area : Neurology
Highest Development Status : Phase II
Sponsor : Takeda Pharmaceutical
Deal Size : $856.0 million
Deal Type : Termination
Lead Product(s) : Gaboxadol
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The primary endpoint of the NEPTUNE study was not achieved. Patients given OV101 showed a 0.7 point improvement in CGI-I-AS over baseline while placebo also showed a 0.8 point improvement in CGI-I-AS.
Brand Name : OV101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 01, 2020
Lead Product(s) : Gaboxadol
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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