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    [{"orgOrder":0,"company":"Palleon Pharmaceuticals","sponsor":"Matrix Capital Management","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Series B Financing","leadProduct":"Sialidase-Fc","moa":"Sialoglycan","graph1":"Oncology","graph2":"Preclinical","graph3":"Palleon Pharmaceuticals","amount2":0.10000000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Palleon Pharmaceuticals \/ Matrix Capital Management","highestDevelopmentStatusID":"4","companyTruncated":"Palleon Pharmaceuticals \/ Matrix Capital Management"},{"orgOrder":0,"company":"Palleon Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Bi-Sialidase","moa":"","graph1":"Oncology","graph2":"IND 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I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Palleon Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Palleon Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Palleon Pharmaceuticals","sponsor":"Shanghai Henlius Biotech","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Collaboration","leadProduct":"Bifunctional HER2-Sialidase","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Palleon Pharmaceuticals","amount2":0.20000000000000001,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.20000000000000001,"dosageForm":"Infusion","sponsorNew":"Palleon Pharmaceuticals \/ Shanghai Henlius Biotech","highestDevelopmentStatusID":"7","companyTruncated":"Palleon Pharmaceuticals \/ Shanghai Henlius Biotech"},{"orgOrder":0,"company":"Palleon Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"E-602","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Palleon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Palleon Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Palleon Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Palleon Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"Cemiplimab","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Palleon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Palleon Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Palleon Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Palleon Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"Cemiplimab","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Palleon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Palleon Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Palleon Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Palleon Pharmaceuticals","sponsor":"Henlius","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"","productType":"Large molecule","year":"2024","type":"Licensing Agreement","leadProduct":"E-602","moa":"","graph1":"Nephrology","graph2":"Preclinical","graph3":"Palleon Pharmaceuticals","amount2":0.10000000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nephrology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Palleon Pharmaceuticals \/ Henlius","highestDevelopmentStatusID":"4","companyTruncated":"Palleon Pharmaceuticals \/ Henlius"}]

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                            01

                            Palleon Pharmaceuticals

                            U.S.A arrow
                            BIO CEO & Investor
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                            Palleon Pharmaceuticals

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                            Lead Product(s) : E-602,Rituximab

                            Therapeutic Area : Nephrology

                            Study Phase : Preclinical

                            Sponsor : Henlius

                            Deal Size : $95.3 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Palleon and Henlius Partner On Glycan Editing for Autoimmune Disease Treatment

                            Details : Henlius has obtained an exclusive license in China for E-602 and will advance its development in combination with Hanlikang for the treatment of autoimmune diseases, including lupus nephritis.

                            Product Name : Undisclosed

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            December 19, 2024

                            Lead Product(s) : E-602,Rituximab

                            Therapeutic Area : Nephrology

                            Highest Development Status : Preclinical

                            Sponsor : Henlius

                            Deal Size : $95.3 million

                            Deal Type : Licensing Agreement

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                            02

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Palleon Pharmaceuticals

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                            Lead Product(s) : E-602,Cemiplimab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palleon Pharmaceuticals Announces First Patient Dosed with E-602 in Combination with Cemiplimab in GLIMMER-01 ...

                            Details : E-602 is a first-in-class glyco-immune checkpoint inhibitor developed by Palleon from the EAGLE (Enzyme Antibody Glyco-Ligand Editing) oncology platform and is being developed in combination with Libtayo (cemiplimab) in patients with advanced cancers.

                            Product Name : E-602

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 22, 2023

                            Lead Product(s) : E-602,Cemiplimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Lead Product(s) : E-602,Cemiplimab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palleon Pharmaceuticals Presents Initial Phase 1 Results from the GLIMMER-01 Clinical Trial for E-602, the Fir...

                            Details : E-602 is a first-in-class, glyco-immune checkpoint inhibitor which restores antitumor immunity by enzymatically degrading immunosuppressive sialoglycans on hypersialylated tumors and immune cells. It is being investegated for lung cancer and melanoma.

                            Product Name : E-602

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 18, 2023

                            Lead Product(s) : E-602,Cemiplimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Palleon Pharmaceuticals

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                            Lead Product(s) : E-602,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palleon to Present on Phase 1/2 E-602 Bi-Sialidase Trial Design at Society for Immunotherapy of Cancer (SITC) ...

                            Details : E-602 Bi-Sialidase is a first-in-class, glyco-immune checkpoint inhibitor which restores anti-tumor immunity by enzymatically degrading immunosuppressive sialoglycans in hypersialylated tumors and immune cells.

                            Product Name : E-602

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 11, 2022

                            Lead Product(s) : E-602,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
                            Not Confirmed

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Lead Product(s) : Bifunctional HER2-Sialidase,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Shanghai Henlius Biotech

                            Deal Size : $196.5 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Palleon Pharmaceuticals and Henlius Enter into Strategic Collaboration to Develop Bifunctional Sialidase Thera...

                            Details : Under the terms of the agreement, Palleon will perform research for E-602 and the parties will then share preclinical and global clinical development responsibilities and costs for the Bifunctional HER2-Sialidase and a second bifunctional sialidase.

                            Product Name : Undisclosed

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            June 28, 2022

                            Lead Product(s) : Bifunctional HER2-Sialidase,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Shanghai Henlius Biotech

                            Deal Size : $196.5 million

                            Deal Type : Collaboration

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                            06

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Lead Product(s) : E-602,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palleon Presents Preclinical Data on Lead Program E-602 and Novel Bifunctional PD-L1-Targeted Sialidase

                            Details : Data presented from non-human primate studies of E-602 (formerly Bi-sialidase) indicate that E-602 exhibits sustained, dose-dependent pharmacodynamic effects on desialylation of immune cells and a wide safety margin.

                            Product Name : E-602

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 08, 2022

                            Lead Product(s) : E-602,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
                            Not Confirmed

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Lead Product(s) : Bi-Sialidase,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palleon Pharmaceuticals to Present Preclinical Data on Lead Program E-602 and Novel Bifunctional PD-L1-Targete...

                            Details : E-602, is a first-in-class engineered human genetic fusion from Palleon’s EAGLE platform, enables creation of novel biological therapeutics by genetic fusion of human sialidase with human monoclonal antibodies.

                            Product Name : E-602

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 09, 2022

                            Lead Product(s) : Bi-Sialidase,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Lead Product(s) : E-602,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palleon Pharmaceuticals Announces First Patient Dosed in Phase 1/2 Study of Lead Glyco-Immunology Drug Candida...

                            Details : GLIMMER-01 study will evaluate safety, pharmacodynamic effects, and antitumor activity of Palleon’s first-in-class immunotherapy, E-602 comrising two engineered human sialidase molecules fused to a human monoclonal antibody used in patients with advanc...

                            Product Name : E-602

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 08, 2022

                            Lead Product(s) : E-602,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Palleon Pharmaceuticals

                            U.S.A arrow
                            BIO CEO & Investor
                            Not Confirmed

                            Palleon Pharmaceuticals

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                            BIO CEO & Investor
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                            Lead Product(s) : Bi-Sialidase

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Palleon Presents Data on Sialoglycan Degradation Platform That Enhances Anti-Tumor T-Cell Immunity

                            Details : Palleon utilized various assays to study the effect of E-602 on naïve, exhausted, and effector T cells. These studies found that desialylation by E-602 enhanced naïve T cell priming/activation, restored exhausted-like T cell functions, and enhanced eff...

                            Product Name : E-602

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 09, 2021

                            Lead Product(s) : Bi-Sialidase

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Palleon Pharmaceuticals

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                            RNA Therapeutics
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                            Palleon Pharmaceuticals

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                            RNA Therapeutics
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                            Lead Product(s) : Sialidase-Fc

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Matrix Capital Management

                            Deal Size : $100.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Palleon Pharmaceuticals Raises $100 million Series B to Develop Drugs Targeting Glycan-Mediated Immune Regulat...

                            Details : The Series B funding will be used to advance Palleon’s pipeline of drug candidates to human clinical trials, including its lead program Sialidase-Fc.

                            Product Name : Undisclosed

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            September 17, 2020

                            Lead Product(s) : Sialidase-Fc

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Matrix Capital Management

                            Deal Size : $100.0 million

                            Deal Type : Series B Financing

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