Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Study Phase : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : sBLA Submission based on recent results from the MIRROR randomized clinical trial, which showed a 71% response rate for patients randomized to receive KRYSTEXXA (Pegloticase) PEGylated uric acid specific enzyme, plus methotrexate for people living with u...
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
October 01, 2022
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Highest Development Status : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Study Phase : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The co-administration of KRYSTEXXA (pegloticase) with an immunomodulator like methotrexate has increasingly been employed in patients with uncontrolled gout to help reduce the development of antidrug antibodies, which can affect treatment efficacy with b...
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
August 11, 2022
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Highest Development Status : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Study Phase : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Application based on recent MIRROR randomized controlled trial results, which showed 71% of patients randomized to receive KRYSTEXXA (pegloticase), a PEGylated uric acid specific enzyme plus methotrexate achieved a complete response.
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
July 03, 2022
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Highest Development Status : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Study Phase : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KRYSTEXXA® (pegloticase injection) is a PEGylated uric acid specific enzyme indicated for the treatment of chronic gout in adult patients refractory to conventional therapy.
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
May 24, 2022
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Highest Development Status : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Study Phase : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The MIRROR randomized controlled trial outcomes provided a clear view of improvements in patient response and reductions in infusion reactions for KRYSTEXXA plus low-dose (15 mg/week) methotrexate compared to KRYSTEXXA plus placebo.
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
January 06, 2022
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Highest Development Status : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Study Phase : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The Company announced two new KRYSTEXXA development programs: KRYSTEXXA, with methotrexate monthly dosing trial and a KRYSTEXXA retreatment trial evaluating KRYSTEXXA, with methotrexate, in patients who have previously failed KRYSTEXXA.
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
November 01, 2021
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Highest Development Status : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Study Phase : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Results show that 71% (71 of 100) of patients who were randomized to receive KRYSTEXXA with methotrexate compared to 40% (21 of 52) of patients who were randomized to receive KRYSTEXXA with placebo achieved the primary endpoint (p<0.001).
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
October 25, 2021
Lead Product(s) : Pegloticase,Methotrexate
Therapeutic Area : Rheumatology
Highest Development Status : Phase IV
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase,Mycophenolate Mofetil
Therapeutic Area : Rheumatology
Study Phase : Phase IV
Sponsor : University of Michigan
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The Reducing Immunogenicity of Pegloticase trial showed that 86% of patients receiving co-therapy of KRYSTEXXA with the immunomodulator mycophenolate mofetil achieved serum uric acid (sUA) ≤ 6 mg/dL at 12 weeks vs 40% of patients (4 of 10) receiving KR...
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
July 04, 2021
Lead Product(s) : Pegloticase,Mycophenolate Mofetil
Therapeutic Area : Rheumatology
Highest Development Status : Phase IV
Sponsor : University of Michigan
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase
Therapeutic Area : Ophthalmology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Peer Reviewed Research Paper Reports that ProtoKinetix's AAGP® Enhanced Stem Cell Vision Restoration
Details : PKTX-001 has shown to significantly improve cell survival and integration into host tissue and will be a valuable asset in the field of regenerative medicine in the future.
Product Name : PKTX-001
Product Type : Enzyme
Upfront Cash : Inapplicable
July 04, 2021
Lead Product(s) : Pegloticase
Therapeutic Area : Ophthalmology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Pegloticase
Therapeutic Area : Rheumatology
Study Phase : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PROTECT trial evaluating the use of KRYSTEXXA (pegloticase injection) in people with chronic gout refractory to conventional therapies who have received a kidney transplant, as well as pharmacokinetic data regarding the concomitant use of KRYSTEXXA and m...
Product Name : Krystexxa
Product Type : Enzyme
Upfront Cash : Inapplicable
May 21, 2021
Lead Product(s) : Pegloticase
Therapeutic Area : Rheumatology
Highest Development Status : Approved FDF
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable