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Find Clinical Drug Pipeline Developments & Deals for Pegloticase

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                          01

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : sBLA Submission based on recent results from the MIRROR randomized clinical trial, which showed a 71% response rate for patients randomized to receive KRYSTEXXA (Pegloticase) PEGylated uric acid specific enzyme, plus methotrexate for people living with u...

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          October 01, 2022

                          Lead Product(s) : Pegloticase,Methotrexate

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The co-administration of KRYSTEXXA (pegloticase) with an immunomodulator like methotrexate has increasingly been employed in patients with uncontrolled gout to help reduce the development of antidrug antibodies, which can affect treatment efficacy with b...

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          August 11, 2022

                          Lead Product(s) : Pegloticase,Methotrexate

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Application based on recent MIRROR randomized controlled trial results, which showed 71% of patients randomized to receive KRYSTEXXA (pegloticase), a PEGylated uric acid specific enzyme plus methotrexate achieved a complete response.

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          July 03, 2022

                          Lead Product(s) : Pegloticase,Methotrexate

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : KRYSTEXXA® (pegloticase injection) is a PEGylated uric acid specific enzyme indicated for the treatment of chronic gout in adult patients refractory to conventional therapy.

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          May 24, 2022

                          Lead Product(s) : Pegloticase,Methotrexate

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The MIRROR randomized controlled trial outcomes provided a clear view of improvements in patient response and reductions in infusion reactions for KRYSTEXXA plus low-dose (15 mg/week) methotrexate compared to KRYSTEXXA plus placebo.

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          January 06, 2022

                          Lead Product(s) : Pegloticase,Methotrexate

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The Company announced two new KRYSTEXXA development programs: KRYSTEXXA, with methotrexate monthly dosing trial and a KRYSTEXXA retreatment trial evaluating KRYSTEXXA, with methotrexate, in patients who have previously failed KRYSTEXXA.

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          November 01, 2021

                          Lead Product(s) : Pegloticase,Methotrexate

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Results show that 71% (71 of 100) of patients who were randomized to receive KRYSTEXXA with methotrexate compared to 40% (21 of 52) of patients who were randomized to receive KRYSTEXXA with placebo achieved the primary endpoint (p<0.001).

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          October 25, 2021

                          Lead Product(s) : Pegloticase,Methotrexate

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The Reducing Immunogenicity of Pegloticase trial showed that 86% of patients receiving co-therapy of KRYSTEXXA with the immunomodulator mycophenolate mofetil achieved serum uric acid (sUA) ≤ 6 mg/dL at 12 weeks vs 40% of patients (4 of 10) receiving KR...

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          July 04, 2021

                          Lead Product(s) : Pegloticase,Mycophenolate Mofetil

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase IV

                          Sponsor : University of Michigan

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PKTX-001 has shown to significantly improve cell survival and integration into host tissue and will be a valuable asset in the field of regenerative medicine in the future.

                          Product Name : PKTX-001

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          July 04, 2021

                          Lead Product(s) : Pegloticase

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PROTECT trial evaluating the use of KRYSTEXXA (pegloticase injection) in people with chronic gout refractory to conventional therapies who have received a kidney transplant, as well as pharmacokinetic data regarding the concomitant use of KRYSTEXXA and m...

                          Product Name : Krystexxa

                          Product Type : Enzyme

                          Upfront Cash : Inapplicable

                          May 21, 2021

                          Lead Product(s) : Pegloticase

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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