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    Horizon Therapeutics

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    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Study Phase : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Sustained Patient Response to KRYSTEXXA® (pegloticase) Injection with Methotrexate Compared to KRYSTEXXA Alon...

    Details : The co-administration of KRYSTEXXA (pegloticase) with an immunomodulator like methotrexate has increasingly been employed in patients with uncontrolled gout to help reduce the development of antidrug antibodies, which can affect treatment efficacy with b...

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    November 08, 2022

    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Highest Development Status : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Horizon Therapeutics

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    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Study Phase : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Data Presented from the MIRROR Randomized Controlled Trial Demonstrate KRYSTEXXA® (pegloticase injection) Plu...

    Details : The MIRROR randomized controlled trial outcomes provided a clear view of improvements in patient response and reductions in infusion reactions for KRYSTEXXA plus low-dose (15 mg/week) methotrexate compared to KRYSTEXXA plus placebo.

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    June 01, 2022

    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Highest Development Status : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Study Phase : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Horizon Therapeutics plc to Present MIRROR Randomized Controlled Trial Primary Endpoint Data at The EULAR 2022...

    Details : KRYSTEXXA® (pegloticase injection) is a PEGylated uric acid specific enzyme indicated for the treatment of chronic gout in adult patients refractory to conventional therapy.

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    May 24, 2022

    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Highest Development Status : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Horizon Therapeutics

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    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Study Phase : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Horizon Therapeutics plc Announces FDA Has Granted Priority Review of the Supplemental Biologics License Appli...

    Details : Application based on recent MIRROR randomized controlled trial results, which showed 71% of patients randomized to receive KRYSTEXXA (pegloticase), a PEGylated uric acid specific enzyme plus methotrexate achieved a complete response.

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    March 07, 2022

    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Highest Development Status : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

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    Horizon Therapeutics

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    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Study Phase : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Horizon Therapeutics plc Submits Supplemental Biologics License for the Concomitant Use of KRYSTEXXA® (peglot...

    Details : sBLA Submission based on recent results from the MIRROR randomized clinical trial, which showed a 71% response rate for patients randomized to receive KRYSTEXXA (Pegloticase) PEGylated uric acid specific enzyme, plus methotrexate for people living with u...

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    January 10, 2022

    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Rheumatology

    Highest Development Status : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

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    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Musculoskeletal

    Study Phase : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Results from PROTECT Trial Evaluating KRYSTEXXA® (Pegloticase Injection) in Kidney Transplant Recipients with...

    Details : The results from the completed PROTECT trial (NCT04087720) demonstrated that Krystexxa (Pegloticase & Methotrexate) provide a substantial and sustained decrease in serum uric acid (sUA) for patients with uncontrolled gout who had received a kidney transp...

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    November 04, 2021

    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Musculoskeletal

    Highest Development Status : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

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    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Musculoskeletal

    Study Phase : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    New Data Being Presented at American College of Rheumatology Convergence 2021 Highlight Horizon’s Commitment...

    Details : The findings indicated that the use of KRYSTEXXA with an immunomodulator may improve persistence to therapy. Approx 90% of the evaluated population met the sUA treatment target and those who received immunomodulation after starting on KRYSTEXXA were less...

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    November 01, 2021

    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Musculoskeletal

    Highest Development Status : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Horizon Therapeutics

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    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Musculoskeletal

    Study Phase : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    MIRROR Randomized Controlled Trial Meets Primary Endpoint and Shows 71% of Patients Achieved a Complete Respon...

    Details : Results show that 71% (71 of 100) of patients who were randomized to receive KRYSTEXXA with methotrexate compared to 40% (21 of 52) of patients who were randomized to receive KRYSTEXXA with placebo achieved the primary endpoint (p<0.001).

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    October 25, 2021

    Lead Product(s) : Pegloticase,Methotrexate

    Therapeutic Area : Musculoskeletal

    Highest Development Status : Phase IV

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Horizon Therapeutics

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    Lead Product(s) : Pegloticase

    Therapeutic Area : Musculoskeletal

    Study Phase : Approved

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Horizon Therapeutics Plc Presents New Data on Robust Pipeline at EULAR European Congress of Rheumatology

    Details : The Prospective Study of Pegloticase in Transplant patients trial is an ongoing Phase 4, open-label trial evaluating the safety and efficacy of KRYSTEXXA in adults with uncontrolled gout who have received a kidney transplant and are on stable immunosuppr...

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    June 02, 2021

    Lead Product(s) : Pegloticase

    Therapeutic Area : Musculoskeletal

    Highest Development Status : Approved

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Horizon Therapeutics

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    Lead Product(s) : Pegloticase

    Therapeutic Area : Musculoskeletal

    Study Phase : Approved

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Horizon Therapeutics plc Highlights Expanding R&D Efforts with Data Presentations at the EULAR European Congre...

    Details : PROTECT trial evaluating the use of KRYSTEXXA (pegloticase injection) in people with chronic gout refractory to conventional therapies who have received a kidney transplant, as well as pharmacokinetic data regarding the concomitant use of KRYSTEXXA and m...

    Product Name : Krystexxa

    Product Type : Large molecule

    Upfront Cash : Not Applicable

    May 21, 2021

    Lead Product(s) : Pegloticase

    Therapeutic Area : Musculoskeletal

    Highest Development Status : Approved

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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