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    [{"orgOrder":0,"company":"Philogen","sponsor":"Sun Pharmaceutical Industries Limited","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"ITALY","productType":"Other Large Molecule","year":"2024","type":"Licensing Agreement","leadProduct":"Onfekafusp Alpha","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase III","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Philogen \/ Sun Pharmaceutical Industries Limited","highestDevelopmentStatusID":"10","companyTruncated":"Philogen \/ Sun Pharmaceutical Industries Limited"},{"orgOrder":0,"company":"Philogen","sponsor":"Sun Pharmaceutical Industries Limited","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2023","type":"Licensing Agreement","leadProduct":"Bifikafusp Alpha","moa":"||IL-2 receptor","graph1":"Oncology","graph2":"Phase III","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Philogen \/ Sun Pharmaceutical Industries Limited","highestDevelopmentStatusID":"10","companyTruncated":"Philogen \/ Sun Pharmaceutical Industries Limited"},{"orgOrder":0,"company":"Philogen","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2023","type":"Collaboration","leadProduct":"Bifikafusp Alpha","moa":"||Angiogenesis","graph1":"Oncology","graph2":"Undisclosed","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Philogen \/ Merck & Co","highestDevelopmentStatusID":"1","companyTruncated":"Philogen \/ Merck & Co"},{"orgOrder":0,"company":"Philogen","sponsor":"Sun Pharmaceutical Industries Limited","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2024","type":"Inapplicable","leadProduct":"Bifikafusp Alpha","moa":"||IL-2 receptor","graph1":"Oncology","graph2":"Phase III","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Philogen \/ Sun Pharmaceutical Industries Limited","highestDevelopmentStatusID":"10","companyTruncated":"Philogen \/ Sun Pharmaceutical Industries Limited"},{"orgOrder":0,"company":"Philogen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"ITALY","productType":"Other Large Molecule","year":"2024","type":"Inapplicable","leadProduct":"Doxorubicin","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase III","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Philogen \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Philogen \/ Inapplicable"},{"orgOrder":0,"company":"Philogen","sponsor":"University Hospital Z\u00fcrich","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2023","type":"Inapplicable","leadProduct":"Fibromun","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Philogen \/ University Hospital Z\u00fcrich","highestDevelopmentStatusID":"7","companyTruncated":"Philogen \/ University Hospital Z\u00fcrich"},{"orgOrder":0,"company":"Philogen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2023","type":"Inapplicable","leadProduct":"Bifikafusp Alpha","moa":"||IL-2 receptor","graph1":"Oncology","graph2":"Phase III","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Philogen \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Philogen \/ Inapplicable"},{"orgOrder":0,"company":"Philogen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2022","type":"Inapplicable","leadProduct":"Bifikafusp Alpha","moa":"||IL-2 receptor","graph1":"Oncology","graph2":"Phase III","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph 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Inapplicable"},{"orgOrder":0,"company":"Philogen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2022","type":"Inapplicable","leadProduct":"Bifikafusp Alpha","moa":"||IL-2 receptor","graph1":"Oncology","graph2":"Phase III","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intratumoral Injection","sponsorNew":"Philogen \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Philogen \/ Inapplicable"},{"orgOrder":0,"company":"Philogen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"Bifikafusp Alpha","moa":"||PD-L1","graph1":"Oncology","graph2":"Phase II","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intralesional Injection","sponsorNew":"Philogen \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Philogen \/ Inapplicable"},{"orgOrder":0,"company":"Philogen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"ITALY","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"Fibromun","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Philogen","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Philogen \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Philogen \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Philogen

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    Philogen

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    Lead Product(s) : Bifikafusp Alpha,L19TNF

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Sun Pharmaceutical Industries Limited

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Philogen and Sun Pharma seek EMA approval for melanoma therapy

    Details : Announced the filing of a marketing authorisation application with the European Medicines Agency for Nidlegy, an investigational neoadjuvant therapy, for locally advanced, fully resectable melanoma.

    Product Name : Nidlegy

    Product Type : Protein

    Upfront Cash : Inapplicable

    April 06, 2024

    Lead Product(s) : Bifikafusp Alpha,L19TNF

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Sun Pharmaceutical Industries Limited

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Lead Product(s) : Onfekafusp Alpha,Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Philogen Updates on Ph III Trial of Onfekafusp Alfa in Advanced Soft Tissue Sarcoma

    Details : L19TNF (onfekafusp alfa), a homotrimer peptide fused to human TNF, is being evaluated with doxorubicin for first-line treatment of advanced or metastatic soft tissue sarcoma.

    Product Name : Fibromun

    Product Type : Other Large Molecule

    Upfront Cash : Inapplicable

    February 20, 2024

    Lead Product(s) : Onfekafusp Alpha,Doxorubicin Hydrochloride

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Lead Product(s) : Onfekafusp Alpha

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Sun Pharmaceutical Industries Limited

    Deal Size : Undisclosed

    Deal Type : Licensing Agreement

    DEALS_DEV arrow-down

    Sun Pharma, Philogen Ink Licensing Deal for Cancer Drug Firbomun

    Details : The agreement aims for the commercialisation of Fibromun (onfekafusp alfa), being investigated in registration trials by Philogen for the treatment of soft tissue sarcoma and glioblastoma.

    Product Name : Fibromun

    Product Type : Other Large Molecule

    Upfront Cash : Undisclosed

    January 10, 2024

    Lead Product(s) : Onfekafusp Alpha

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Sun Pharmaceutical Industries Limited

    Deal Size : Undisclosed

    Deal Type : Licensing Agreement

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    Philogen

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    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Nidlegy™ Phase III PIVOTAL Trial Meets the Study’s Primary Objective in Patients with Locally Advanced Ful...

    Details : Nidlegy (bifikafusp alfa & onfekafusp alfa) is designed for the treatment of skin cancer. It consists of two active ingredients, L19IL2 and L19TNF which are manufactured independently, and which are mixed prior to intralesional administration.

    Product Name : Nidlegy

    Product Type : Protein

    Upfront Cash : Inapplicable

    October 16, 2023

    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Philogen

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    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Sun Pharmaceutical Industries Limited

    Deal Size : Undisclosed

    Deal Type : Licensing Agreement

    DEALS_DEV arrow-down

    Sun Pharma and Philogen Sign Licence Agreement for Anti-Cancer Therapy

    Details : Under the agreement, Sun Pharma will have exclusive rights to commercialise Nidlegy (bifikafusp alfa), a new anti-cancer biopharmaceutical, being developed by Philogen for melanoma and non-melanoma skin cancers, in the territories of Europe, Australia an...

    Product Name : Nidlegy

    Product Type : Protein

    Upfront Cash : Undisclosed

    May 30, 2023

    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Sun Pharmaceutical Industries Limited

    Deal Size : Undisclosed

    Deal Type : Licensing Agreement

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    Philogen

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    Lead Product(s) : Fibromun,Lomustine

    Therapeutic Area : Oncology

    Study Phase : Phase I/ Phase II

    Sponsor : University Hospital Zürich

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Philogen Publishes New Data on A Fibromun-Based Treatment Combination in Science Translational Medicine in Col...

    Details : L19TNF is a fully-human immunomodulatory product consisting of the L19 antibody and TNF. The L19 antibody is specific to the EDB domain of fibronectin and mediates selective localization of TNF to the site of disease while sparing healthy organs.

    Product Name : L19TNF

    Product Type : Protein

    Upfront Cash : Inapplicable

    May 24, 2023

    Lead Product(s) : Fibromun,Lomustine

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Sponsor : University Hospital Zürich

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Study Phase : Undisclosed

    Sponsor : Merck & Co

    Deal Size : Undisclosed

    Deal Type : Collaboration

    DEALS_DEV arrow-down

    Philogen Announces Clinical Trial Collaboration with MSD

    Details : Under the supply agreement, MSD provides their anti-PD-1 therapy, KEYTRUDA® (pembrolizumab), to be evaluated in combination with Philogen's immunocytokines L19IL2, L19TNF, and Nidlegy (bifikafusp alfa) in a randomized Phase II clinical trial in unresect...

    Product Name : Nidlegy

    Product Type : Protein

    Upfront Cash : Undisclosed

    January 06, 2023

    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Highest Development Status : Undisclosed

    Sponsor : Merck & Co

    Deal Size : Undisclosed

    Deal Type : Collaboration

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    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Philogen Announces Enrolment of 214 Patients in the Nidlegy™ Phase III European Clinical Trial For the Treat...

    Details : Nidlegy (bifikafusp alfa) is combination of the immunocytokines L19IL2 and L19TNF, which is being developed as intralesional treatment for patients with advanced locoregional melanoma and non-melanoma skin cancers.

    Product Name : Nidlegy

    Product Type : Protein

    Upfront Cash : Inapplicable

    July 25, 2022

    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Philogen Receives Authorisation to Initiate New Study in France to Evaluate Nidlegy™ in Several Nonmelanoma ...

    Details : Nidlegy™, the combination of the two active principles bifikafusp alfa (L19IL2) and onfekafusp alfa (L19TNF), has already shown promising results in the intralesional treatment of patients with advanced melanoma and in BCC and cSCC in an ongoing Phase ...

    Product Name : Nidlegy

    Product Type : Protein

    Upfront Cash : Inapplicable

    February 17, 2022

    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Philogen

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    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Study Phase : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Philogen Announces the Completion of A Second Interim Analysis of Its Phase III Clinical Program with Nidlegy ...

    Details : Nidlegy, as a neoadjuvant was found to be well-tolerated and 149 out of the anticipated 214 patients have been safely treated in PIVOTAL phase III trial in melanoma patients with locally advanced, fully resectable metastatic cancer.

    Product Name : Nidlegy

    Product Type : Protein

    Upfront Cash : Inapplicable

    January 13, 2022

    Lead Product(s) : Bifikafusp Alpha,Onfekafusp Alpha

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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