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    [{"orgOrder":0,"company":"Pieris Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"PRS-343","moa":"CD137","graph1":"Oncology","graph2":"Phase II","graph3":"Pieris Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Pieris Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Pieris Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Pieris Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"PRS-343","moa":"CD137","graph1":"Oncology","graph2":"Phase II","graph3":"Pieris Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph 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                            01

                            Pieris Pharmaceuticals

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                            Lead Product(s) : SGN-BB228

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : Palvella Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Palvella Closes Pieris Merger and $78.9M Private Placement

                            Details : Through the merger, Palvella will acquire the Pieris pipeline, including oncology products such as PRS-346 (SGN-BB228), which is being evaluated for the treatment of advanced melanoma.

                            Product Name : Undisclosed

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            December 13, 2024

                            Lead Product(s) : SGN-BB228

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : Palvella Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            02

                            Pieris Pharmaceuticals

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                            Lead Product(s) : Elarekibep

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : AstraZeneca

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Pieris Pharmaceuticals Announces AstraZeneca Discontinuation of Phase 2a Trial of Elarekibep (PRS-060/AZD1402)...

                            Details : PRS-060/AZD-1402 (elarekibep) is Pieris’ lead respiratory Anticalin®-based drug candidate and an inhaled IL-4 receptor alpha inhibitor, under development for the treatment of asthma.

                            Product Name : PRS-060

                            Product Type : Peptide

                            Upfront Cash : Not Applicable

                            June 21, 2023

                            Lead Product(s) : Elarekibep

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : AstraZeneca

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Pieris Pharmaceuticals

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                            Lead Product(s) : Elarekibep

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : AstraZeneca

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Pieris Pharmaceuticals Announces Successful Completion of Safety Review for 10 mg Dose of Phase 2a Trial of El...

                            Details : PRS-060 (elarekibep) blocks the IL-4Ralpha immunoreceptor, inhibiting small IL-4 and IL-13 proteins that drive a cascade of inflammatory responses in the lungs. It is being developed for the treatment of moderate-to-severe asthma.

                            Product Name : PRS-060

                            Product Type : Peptide

                            Upfront Cash : Not Applicable

                            May 04, 2023

                            Lead Product(s) : Elarekibep

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : AstraZeneca

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Pieris Pharmaceuticals

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                            Lead Product(s) : PRS-342

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Boston Pharmaceuticals

                            Deal Size : $363.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Pieris Pharmaceuticals and Boston Pharmaceuticals Ink Exclusive Worldwide Product License for PRS-342

                            Details : Under the terms of the agreement, Boston Pharmaceuticals has exclusively licensed worldwide rights to PRS-342. Boston Pharmaceuticals will be primarily responsible for development of the program, with both parties collaborating during the IND-enabling st...

                            Product Name : PRS-342

                            Product Type : Large molecule

                            Upfront Cash : $10.0 million

                            April 26, 2021

                            Lead Product(s) : PRS-342

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Boston Pharmaceuticals

                            Deal Size : $363.0 million

                            Deal Type : Licensing Agreement

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                            05

                            Pieris Pharmaceuticals

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                            Lead Product(s) : Cinrebafusp alfa,Tucatinib

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Seagen

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Pieris Announces Amendment of Existing Collaboration with Seagen to Evaluate Cinrebafusp Alfa in Combination w...

                            Details : Pieris' option to co-develop and co-commercialize the second of 3 programs in the collaboration has been amended to provide it with a co-promotion option in the U.S, with Seagen solely responsible for the development and overall commercialization of that...

                            Product Name : PRS-343

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            March 25, 2021

                            Lead Product(s) : Cinrebafusp alfa,Tucatinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Seagen

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            06

                            Pieris Pharmaceuticals

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                            Lead Product(s) : PRS-343

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Lifts Partial Clinical Hold Pieris Pharmaceuticals' Prs-343 Phase 1 Studies

                            Details : U.S. Food and Drug Administration (FDA) has lifted the previously announced partial clinical hold on the phase 1 studies of PRS-343. As previously guided, the Company intends to move into a proof-of-concept study of PRS-343 in gastroesophageal cancer.

                            Product Name : PRS-343

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 19, 2021

                            Lead Product(s) : PRS-343

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Pieris Pharmaceuticals

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                            Lead Product(s) : PRS-343,Ramucirumab,Paclitaxel

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Eli Lilly

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Pieris and Lilly Ink Clinical Trial Collaboration to Evaluate Combination of Prs-343 with Ramucirumab and Pacl...

                            Details : Lilly to supply Pieris with ramucirumab for the study as well as collaborate on data from the trial. Pieris is working towards initiation of a phase 2 single-arm combination study for the second-line treatment of HER2-positive gastric cancer later this y...

                            Product Name : PRS-343

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            August 10, 2020

                            Lead Product(s) : PRS-343,Ramucirumab,Paclitaxel

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Eli Lilly

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            08

                            Pieris Pharmaceuticals

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                            Lead Product(s) : PRS-343,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Pieris Pharmaceuticals Announces Oral Presentation Of Phase 1 Data For 4-1bb/Her2 Bispecific Prs-343 At ESMO V...

                            Details : Company will present phase 1 dose-escalation monotherapy and combination with atezolizumab data for PRS-343, a 4-1BB/HER2 bispecific for the treatment of HER2-positive solid tumors, in an oral presentation session at the European Society for Medical Onco...

                            Product Name : PRS-343

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            July 23, 2020

                            Lead Product(s) : PRS-343,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Pieris Pharmaceuticals

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                            Lead Product(s) : PRS-343,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Pieris Pharmaceuticals Announces Partial Clinical Hold On PRS-343

                            Details : The partial hold follows discussions with FDA regarding the Company's in-use study supporting the technical setup for clinical administration of PRS-343.

                            Product Name : PRS-343

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            July 20, 2020

                            Lead Product(s) : PRS-343,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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