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                          Top Deals by Deal Size (USD bn)

                          01

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : The net proceeds will be used to supports the clinical development of 186RNL (rhenium-186 obisbemeda), a novel injectable radiotherapy, for leptomeningeal metastases.

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 07, 2024

                          Lead Product(s) : Rhenium-186 Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : CPRIT

                          Deal Size : $17.6 million

                          Deal Type : Funding

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                          02

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Proceeds will advance the Re-SPECT LM program evaluating 186RNL (rhenium-186 obisbemeda), designed to emit beta energy for tumor destruction.

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : $6.5 million

                          May 06, 2024

                          Lead Product(s) : Rhenium-186 Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : AIGH Capital Management LLC

                          Deal Size : $18.0 million

                          Deal Type : Financing

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                          03

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Proceeds will advance clinical trials for pediatric brain cancer, evaluating 186RNL (rhenium-186 obisbemeda) for tumor tissue destruction.

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          April 22, 2024

                          Lead Product(s) : Rhenium-186 Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : United States Department of Defense

                          Deal Size : $3.0 million

                          Deal Type : Funding

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                          04

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : 186RNL (Rhenium (186Re) obisbemeda) is a novel injectable radiotherapy formulated for direct high-dose radiation delivery in CNS tumors, currently evaluated for leptomeningeal metastases.

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 11, 2024

                          Lead Product(s) : Rhenium (186 Re) Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : 186RNL (rhenium-186 obisbemeda) is a injectable radiotherapy specifically formulated to deliver highly targeted high dose radiation in CNS tumors, which is investigated for the treatment of Obisbemeda for the Treatment of Breast Cancer with Leptomeningea...

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 03, 2023

                          Lead Product(s) : Rhenium-186 Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : 186RNL (rhenium-186 obisbemeda) is a injectable radiotherapy specifically formulated to deliver highly targeted high dose radiation in CNS tumors, which is investigated for the treatment of leptomeningeal metastases.

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 10, 2023

                          Lead Product(s) : Rhenium-186 Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : The funding will cover the majority of the development costs of the Company’s lead investigational targeted radiotherapeutic, 186RNL (rhenium-186 obisbemeda), for the treatment of patients with leptomeningeal metastases (LM).

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 11, 2023

                          Lead Product(s) : Rhenium-186 Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : CPRIT

                          Deal Size : $17.6 million

                          Deal Type : Funding

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                          08

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : 186RNL (rhenium-186 obisbemeda) is a injectable radiotherapy specifically formulated to deliver highly targeted high dose radiation in CNS tumors. It has the potential to reduce risks and improve outcomes for CNS cancer patients, with a more targeted and...

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 05, 2023

                          Lead Product(s) : Rhenium-186 Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          blank

                          09

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Under the agreement, Piramal will produce additional cGMP liposome intermediate drug product to meet the increase in demand for its lead investigational targeted radiotherapeutic, rhenium (186Re) obisbemeda, for ongoing and planned clinical trials.

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          May 02, 2023

                          Lead Product(s) : Rhenium Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Piramal Pharma Solutions

                          Deal Size : Undisclosed

                          Deal Type : Expanded Collaboration

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                          10

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : 186RNL (rhenium-186 obisbemeda) is a injectable radiotherapy specifically formulated to deliver highly targeted high dose radiation in CNS tumors. It has the potential to reduce risks and improve outcomes for CNS cancer patients, with a more targeted and...

                          Brand Name : 186RNL

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 19, 2023

                          Lead Product(s) : Rhenium-186 Obisbemeda

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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