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    [{"orgOrder":0,"company":"Seagen","sponsor":"F. Hoffmann-La Roche","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Funding","leadProduct":"Polatuzumab Vedotin","moa":"","graph1":"Oncology","graph2":"Approved","graph3":"Seagen","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Seagen \/ Roche","highestDevelopmentStatusID":"12","companyTruncated":"Seagen \/ Roche"},{"orgOrder":0,"company":"Chugai Pharmaceutical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"JAPAN","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Polatuzumab Vedotin","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Chugai Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Chugai Pharmaceutical \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Chugai Pharmaceutical \/ Not Applicable"},{"orgOrder":0,"company":"Chugai Pharmaceutical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Polatuzumab Vedotin","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Chugai Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Chugai Pharmaceutical \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Chugai Pharmaceutical \/ Not Applicable"},{"orgOrder":0,"company":"F. 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    Find Clinical Drug Pipeline Developments & Deals for Polatuzumab Vedotin

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    Polatuzumab Vedotin

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                            01

                            Genentech

                            U.S.A arrow
                            euroPLX 86 Munich
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                            Genentech

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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Advisory Committee Votes in Favor of the Clinical Benefit of Genentech's Polivy Combination for People Wit...

                            Details : Polivy® (polatuzumab vedotin-piiq) is a first-in-class anti-CD79b antibody-drug conjugate (ADC). It binds to cancer cells such as CD79b and destroys these B cells through the delivery of an anti-cancer agent, which is thought to minimize the effects on ...

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 09, 2023

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Chugai Pharmaceutical

                            Japan arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            Chugai Pharmaceutical

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                            euroPLX 86 Munich
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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Chugai Obtains Regulatory Approval for POLIVY for Additional Indication of Previously Untreated Diffuse Large ...

                            Details : Polivy® intravenous infusion 30 mg and 140 mg [generic name: polatuzumab vedotin (genetical recombination)] for an additional indication of treatment of patients with previously untreated diffuse large B-cell lymphoma (DLBCL).

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 24, 2022

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            F. Hoffmann-La Roche

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                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Accepts Supplemental Biologics License Application for Roche’s Polivy Combination for People With Previo...

                            Details : Polivy® (polatuzumab vedotin-piiq) in combination with Rituxan® (rituximab) plus cyclophosphamide, doxorubicin and prednisone (R-CHP) for the treatment of people with previously untreated diffuse large B-cell lymphoma (DLBCL).

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 16, 2022

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            ADC Therapeutics

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            ADC Therapeutics

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                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : Loncastuximab Tesirine-lpyl,Polatuzumab Vedotin

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ADC Therapeutics Doses First Patient in Phase 1b Clinical Trial of ZYNLONTA® (loncastuximab tesirine-lpyl) in...

                            Details : ZYNLONTA® (loncastuximab tesirine-lpyl), is a CD19-directed antibody drug conjugate (ADC). Once bound to a CD19-expressing cell, ZYNLONTA is internalized by the cell, where enzymes release a pyrrolobenzodiazepine (PBD) payload.

                            Brand Name : Zynlonta

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 29, 2022

                            Lead Product(s) : Loncastuximab Tesirine-lpyl,Polatuzumab Vedotin

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Roche's Polivy Combination Approved by European Commission for People With Previously Untreated Diffuse Large ...

                            Details : Approval is based on pivotal data from the phase III POLARIX study, where Polivy (Polatuzumab Vedotin) plus R-CHP significantly improved progression-free survival with comparable safety versus the standard of care, R-CHOP.

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 25, 2022

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            CHMP Recommends EU Approval of Roche's Polivy Combination for People with Previously Untreated Diffuse Large B...

                            Details : Polivy plus R-CHP showed first clinically meaningful improvement in PFS with comparable safety in people with previously untreated diffuse large B-cell lymphoma (DLBCL) over the standard of care in more than 20 years.

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 25, 2022

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Roche’s Polivy Combination Reduced the Risk of Disease Worsening or Death by 27% in People with Previously U...

                            Details : Polivy (polatuzumab vedotin) plus R-CHP is the first treatment regimen to significantly improve outcomes in previously untreated diffuse large B-cell lymphoma in more than 20 years, potentially transforming treatment for people with this disease.

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 14, 2021

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Chugai Pharmaceutical

                            Japan arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            Chugai Pharmaceutical

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                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Chugai Files for Additional Indication of Polivy for Previously Untreated Diffuse Large B-cell Lymphoma

                            Details : Polivy (polatuzumab vedotin) plus R-CHP significantly improved outcomes in previously untreated diffuse large B-cell lymphoma (DLBCL) compared to the standard of care for the first time in 20 year.

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 10, 2021

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Genentech

                            U.S.A arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            Genentech

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                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Genentech to Present New Pivotal Data at ASH 2021 From Broad and Comprehensive Portfolio, Challenging Treatmen...

                            Details : First presentation of efficacy and safety data from the Phase III POLARIX study met its primary endpoint of improving progression-free survival, showing Polivy® (polatuzumab vedotin-piiq) plus Rituxan reduced disease worsening or death.

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 23, 2021

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            F. Hoffmann-La Roche

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                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Phase III Study Shows Roche's Polivy Plus R-CHP Is the First Regimen in 20 Years to Significantly Improve Outc...

                            Details : Polivy is used as an off-the-shelf, fixed-duration treatment option in the relapsed or refractory DLBCL setting, and is approved in combination with bendamustine and MabThera/Rituxan for the treatment of R/R DLBCL in more than 60 countries worldwide.

                            Brand Name : Polivy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 09, 2021

                            Lead Product(s) : Polatuzumab Vedotin,Rituximab,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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