[{"orgOrder":0,"company":"Polpharma","sponsor":"Pikralida biopharmaceutical","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"POLAND","productType":"Other Small Molecule","year":"2022","type":"Partnership","leadProduct":"PKL-021","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"Polpharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Polpharma \/ Pikralida biopharmaceutical","highestDevelopmentStatusID":"4","companyTruncated":"Polpharma \/ Pikralida biopharmaceutical"},{"orgOrder":0,"company":"Polpharma","sponsor":"Ryvu Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"POLAND","productType":"Other Small Molecule","year":"2023","type":"Agreement","leadProduct":"RVU120","moa":"CDK8\/19","graph1":"Oncology","graph2":"Preclinical","graph3":"Polpharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Polpharma \/ Ryvu Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Polpharma \/ Ryvu Therapeutics"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : RVU120

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Sponsor : Ryvu Therapeutics

                          Deal Size : $1.0 million

                          Deal Type : Agreement

                          Details : RVU120 is a selective, first-in-class dual CDK8/CDK19 kinase inhibitor that has shown signs of clinical activity in treated patients, as well as efficacy in numerous in vitro and in vivo models of hematologic malignancies and solid tumors.

                          Product Name : RVU120

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 07, 2023

                          Lead Product(s) : RVU120

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Ryvu Therapeutics

                          Deal Size : $1.0 million

                          Deal Type : Agreement

                          Polpharma CB

                          02

                          Lead Product(s) : PKL-021

                          Therapeutic Area : Neurology

                          Study Phase : Preclinical

                          Sponsor : Pikralida biopharmaceutical

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Details : The partnership involves manufacturing of the drug substance of the clinical candidate PKL-021, needed to support the preclinical research program and the production of an investigational medicinal product for the phase one clinical trial.

                          Product Name : PKL-021

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          July 19, 2022

                          Lead Product(s) : PKL-021

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Pikralida biopharmaceutical

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Polpharma CB