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    [{"orgOrder":0,"company":"Blueprint Medicines","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Pralsetinib","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Blueprint Medicines","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Blueprint Medicines \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Blueprint Medicines \/ Not Applicable"},{"orgOrder":0,"company":"Blueprint Medicines","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Pralsetinib","moa":"Tyrosine protein kinase receptor RET","graph1":"Oncology","graph2":"Approved","graph3":"Blueprint Medicines","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Blueprint Medicines \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Blueprint Medicines \/ Not Applicable"},{"orgOrder":0,"company":"Burning Rock Dx","sponsor":"CStone Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Collaboration","leadProduct":"Pralsetinib","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Burning Rock Dx","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Burning Rock Dx \/ CStone Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Burning Rock Dx \/ CStone Pharmaceuticals"},{"orgOrder":0,"company":"Blueprint Medicines","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Pralsetinib","moa":"Tyrosine protein kinase receptor RET","graph1":"Oncology","graph2":"Phase III","graph3":"Blueprint Medicines","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Blueprint Medicines \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Blueprint Medicines \/ Not Applicable"},{"orgOrder":0,"company":"Blueprint Medicines","sponsor":"F. 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                            01

                            Optime Care

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Rigel Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Optime Care Announces Enhanced Partnership with Rigel for GAVRETO® Patients

                            Details : The partnership aims to assist in the commercialization of Rigel Pharmaceuticals' approved product, Gavreto (pralsetinib), which is indicated for RET fusion-positive non-small cell lung cancer.

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            June 27, 2024

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Rigel Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            02

                            Blueprint Medicines

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Rigel Pharmaceuticals

                            Deal Size : $117.5 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Rigel Pharmaceuticals Acquires U.S. Rights to GAVRETO®

                            Details : Through the acquisition, Rigel will able to commercialize the Gavreto (pralsetinib), which is an FDA-approved targeted therapy for RET fusion-positive metastatic non-small cell lung cancer.

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            February 22, 2024

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Rigel Pharmaceuticals

                            Deal Size : $117.5 million

                            Deal Type : Acquisition

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                            03

                            Blueprint Medicines

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $1,702.0 million

                            Deal Type : Termination

                            DEALS_DEV arrow-down

                            Blueprint Medicines to Regain Global Rights to GAVRETO® (pralsetinib) from Roche

                            Details : Under the terms of the agreement, Blueprint Medicines will regain global commercialization and development rights to Gavreto (pralsetinib), a once-daily oral targeted therapy, excluding Greater China.

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : $775.0 million

                            February 23, 2023

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $1,702.0 million

                            Deal Type : Termination

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                            04

                            CStone Pharmaceuticals

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            CStone Announces the NDA Approval of GAVRETO® (pralsetinib) for the Treatment of Advanced RET Fusion-Positive...

                            Details : Gavreto (pralsetinib) is a kinase inhibitor of wild-type RET and oncogenic RET fusions (CCDC6-RET) and mutations. It is approved for adult patients with locally advanced or metastatic RET fusion-positive NSCLC or thyroid cancer and advanced or metastatic...

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 17, 2023

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Blueprint Medicines

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Royalty Pharma

                            Deal Size : $340.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Blueprint Medicines Announces Transformative $1.25 Billion Strategic Financing Collaborations with Sixth Stree...

                            Details : GAVRETO is an important precision therapy that has been incredibly meaningful for patients with metastatic, RET fusion-positive non-small cell lung cancer who may have otherwise had limited options.

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : $175.0 million

                            June 30, 2022

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Royalty Pharma

                            Deal Size : $340.0 million

                            Deal Type : Collaboration

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                            06

                            F. Hoffmann-La Roche

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            European Commission Approves Roche’s Gavreto (Pralsetinib) For the Treatment of Adults With RET Fusion-Posit...

                            Details : Preclinical data have shown that Gavreto inhibits primary RET fusions and mutations that cause cancer in subsets of patients, as well as secondary RET mutations predicted to drive resistance to treatment.

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 19, 2021

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            F. Hoffmann-La Roche

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Blueprint Medicines

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Roche Receives Positive CHMP Opinion For Gavreto® (pralsetinib) For the Treatment of Adults With RET Fusion-P...

                            Details : Gavreto® (pralsetinib) is approved once-daily, oral targeted treatment designed to selectively target rearranged during transfection (RET) alterations. Gavreto showed robust and durable clinical responses in people with NSCLC with RET fusions.

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 17, 2021

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Blueprint Medicines

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            CStone Pharmaceuticals

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Blueprint Medicines

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            CStone Reports Efficacy and Safety Data from the ARROW Trial of Pralsetinib in Advanced Lung Cancer after Plat...

                            Details : Pralsetinib showed robust and durable anti-tumor activity and a well-tolerated safety profile in patients that enrolled at China sites who had advanced RET fusion-positive non-small cell lung cancer (NSCLC) previously treated with platinum-based chemothe...

                            Brand Name : BLU-667

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 28, 2021

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Blueprint Medicines

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Catalent Pharma Solutions

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Blueprint Medicines

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Catalent Signs Commercial Supply Agreement with Blueprint Medicines Following FDA Approval of GAVRETO™ (pral...

                            Details : Developed by Blueprint Medicines, GAVRETO is a new therapy indicated for the treatment of adults with metastatic RET fusion-positive non-small cell lung cancer as detected by an FDA approved test. This agreement will continue Catalent’s involvement in ...

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            November 23, 2020

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Blueprint Medicines

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            Blueprint Medicines

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                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Genentech

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Blueprint Medicines Reports ARROW Trial Data at ESMO Virtual Congress 2020 Demonstrating Durable Clinical Bene...

                            Details : GAVRETO demonstrated consistent clinical activity in patients across lines of therapy and regardless of RET mutation genotypes, including a high response rate in patients with gatekeeper mutations resistant to multi-kinase inhibitors.

                            Brand Name : Gavreto

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 20, 2020

                            Lead Product(s) : Pralsetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Genentech

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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