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                          01

                          Pharmtech & Ingredients
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                          Details : PBGENE-HBV first and only potentially curative gene editing program that acts as a cccDNA/HBV DNA inhibitor. It is being developed for the treatment of chronic hepatitis B.

                          Brand Name : PBGENE-HBV

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          October 24, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
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                          Details : PBGENE-HBV first and only potentially curative gene editing program that acts as a cccDNA/HBV DNA inhibitor. It is being developed for the treatment of chronic hepatitis B.

                          Brand Name : PBGENE-HBV

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 30, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
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                          Details : Imugene assumed global rights to azer-cel for cancer, the ongoing clinical execution for PBCAR0191 (azercabtagene zapreleucel) in LBCL patients who have relapsed following autologous CAR T treatment.

                          Brand Name : PBCAR0191

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $21.0 million

                          September 03, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Imugene

                          Deal Size : $227.0 million

                          Deal Type : Licensing Agreement

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                          04

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Azercabtagene Zapreleucel (azer-cel) is an allogeneic CD19 CAR T cell therapy, which is being investigated for progressive forms of multiple sclerosis.

                          Brand Name : Azer-cel

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 09, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Recipient : TG Therapeutics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : PBGENE-HBV aims to eliminate both cccDNA and inactivate HBV DNA, currently in trials for Chronic Hepatitis B.

                          Brand Name : PBGENE-HBV

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          May 08, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : $0.3 million

                          Deal Type : Private Placement

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                          06

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Precision exercised its option to regain rights for the programs, including its novel proprietary ARCUS® platform to develop in vivo gene editing therapies for sophisticated gene edits.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $100.0 million

                          April 16, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Sponsor : Prevail Therapeutics

                          Deal Size : $555.0 million

                          Deal Type : Termination

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                          07

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : ECUR-506 incorporates an ARCUS nuclease vector for gene editing in the PCSK9 gene locus and a donor vector inserting the functional OTC gene to treat Ornithine Transcarbamylase deficiency in infants.

                          Brand Name : ECUR-506

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 06, 2024

                          Lead Product(s) : ECUR-506

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The net proceeds will be used in the clinical development of PBGENE-HBV, designed to both eliminate cccDNA and inactivate HBV DNA. It is being evaluated for the treatment of Chronic Hepatitis B.

                          Brand Name : PBGENE-HBV

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 01, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Guggenheim Securities, LLC

                          Deal Size : $40.0 million

                          Deal Type : Public Offering

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                          09

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The net proceeds will be used in the clinical development of PBGENE-HBV, designed to both eliminate cccDNA and inactivate HBV DNA. It is being evaluated for the treatment of Chronic Hepatitis B.

                          Brand Name : PBGENE-HBV

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          February 29, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Guggenheim Securities, LLC

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          10

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : PBGENE-HBV first and only potentially curative gene editing program that acts as a cccDNA/HBV DNA inhibitor. It is being developed for the treatment of chronic hepatitis B.

                          Brand Name : PBGENE-HBV

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          February 14, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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