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                          01

                          Peptide-Based Therapeutics Summit
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                          Peptide-Based Therapeutics Summit
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                          Details : PBGENE-DMD restores the body’s ability to produce a functional dystrophin protein, currently being investigated for duchenne muscular dystrophy.

                          Product Name : PBGENE-DMD

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 19, 2025

                          Lead Product(s) : PBGENE-DMD

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : PBGENE-HBV first and only potentially curative gene editing program that acts as a cccDNA/HBV DNA inhibitor. It is being developed for the treatment of chronic hepatitis B.

                          Product Name : PBGENE-HBV

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 17, 2025

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : PBGENE-HBV first and only potentially curative gene editing program that acts as a cccDNA/HBV DNA inhibitor. It is being developed for the treatment of chronic hepatitis B.

                          Product Name : PBGENE-HBV

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 19, 2025

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : PBGENE-HBV first and only potentially curative gene editing program that acts as a cccDNA/HBV DNA inhibitor. It is being developed for the treatment of chronic hepatitis B.

                          Product Name : PBGENE-HBV

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 18, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : TG Therapeutics received exclusive worldwide rights to develop and commercialize Azercabtagene Zapreleucel (azer-cel), an allogeneic CD19 CAR T cell therapy for autoimmune diseases.

                          Product Name : PBCAR0191

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $17.5 million

                          December 02, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Sponsor : TG Therapeutics

                          Deal Size : $305.5 million

                          Deal Type : Licensing Agreement

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                          06

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : PBGENE-HBV first and only potentially curative gene editing program that acts as a cccDNA/HBV DNA inhibitor. It is being developed for the treatment of chronic hepatitis B.

                          Product Name : PBGENE-HBV

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          October 24, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : PBGENE-HBV first and only potentially curative gene editing program that acts as a cccDNA/HBV DNA inhibitor. It is being developed for the treatment of chronic hepatitis B.

                          Product Name : PBGENE-HBV

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 30, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : TG will receive exclusive worldwide rights to develop and commercialize Azercabtagene Zapreleucel, an allogeneic CD19 CAR T cell therapy for autoimmune diseases and non-oncology indications.

                          Product Name : PBCAR0191

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $7.5 million

                          September 01, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Sponsor : TG Therapeutics

                          Deal Size : $315.5 million

                          Deal Type : Licensing Agreement

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                          09

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : PBGENE-HBV aims to eliminate both cccDNA and inactivate HBV DNA, currently in trials for Chronic Hepatitis B.

                          Product Name : PBGENE-HBV

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          August 05, 2024

                          Lead Product(s) : PBGENE-HBV

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : $0.3 million

                          Deal Type : Private Placement

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                          10

                          Peptide-Based Therapeutics Summit
                          Not Confirmed
                          Peptide-Based Therapeutics Summit
                          Not Confirmed

                          Details : ECUR-506 incorporates an ARCUS nuclease vector for gene editing in the PCSK9 gene locus and a donor vector inserting the functional OTC gene to treat Ornithine Transcarbamylase deficiency in infants.

                          Product Name : ECUR-506

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          June 03, 2024

                          Lead Product(s) : ECUR-506

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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