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    [{"orgOrder":0,"company":"Prevail Therapeutics","sponsor":"Eli Lilly","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Acquisition","leadProduct":"Methylprednisolone","moa":"||GBA1 gene","graph1":"Genetic Disease","graph2":"Phase I\/ Phase II","graph3":"Prevail Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intracisternal Injection","sponsorNew":"Prevail Therapeutics \/ Eli Lilly","highestDevelopmentStatusID":"7","companyTruncated":"Prevail Therapeutics \/ Eli Lilly"},{"orgOrder":0,"company":"Prevail Therapeutics","sponsor":"Eli Lilly","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Acquisition","leadProduct":"Methylprednisolone","moa":"||GBA1 gene","graph1":"Neurology","graph2":"Phase I\/ Phase II","graph3":"Prevail 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    Find Clinical Drug Pipeline Developments & Deals by Prevail Therapeutics

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                            01

                            Prevail Therapeutics

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                            Prevail Therapeutics

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                            Lead Product(s) : PR001,Methylprednisolone

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Eli Lilly

                            Deal Size : $1,040.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Lilly Completes Acquisition of Prevail Therapeutics

                            Details : Acquisition will set up a gene therapy program at Lilly, based on Prevail's portfolio of neuroscience assets, including the lead candidate, PR001, and will broaden Lilly's commitment to use novel modalities to address fatal genetic forms of neurodegenera...

                            Product Name : PR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            January 22, 2021

                            Lead Product(s) : PR001,Methylprednisolone

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Eli Lilly

                            Deal Size : $1,040.0 million

                            Deal Type : Acquisition

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                            02

                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Prevail Therapeutics

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                            Lead Product(s) : PR001,Methylprednisolone

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Eli Lilly

                            Deal Size : $1,040.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Lilly Announces Agreement to Acquire Prevail Therapeutics

                            Details : Acquisition will establish a gene therapy program at Lilly, anchored by Prevail's portfolio of neuroscience assets, and will broaden Lilly's commitment to use novel modalities to attempt to address otherwise fatal genetic forms of neurodegenerative disea...

                            Product Name : PR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            December 15, 2020

                            Lead Product(s) : PR001,Methylprednisolone

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Eli Lilly

                            Deal Size : $1,040.0 million

                            Deal Type : Acquisition

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                            03

                            Prevail Therapeutics

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                            Lead Product(s) : PR001

                            Therapeutic Area : Genetic Disease

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevail Therapeutics’ PR001 Gets Orphan Drug Designation By FDA

                            Details : The Company also announced that the FDA has granted Rare Pediatric Disease Designation for PR001 for the treatment of neuronopathic Gaucher disease (nGD), the most severe form of the condition.

                            Product Name : PR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 02, 2020

                            Lead Product(s) : PR001

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Lead Product(s) : PR006,Methylprednisolone

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevail Therapeutics Receives European Commission Orphan Designation for PR006 for the Treatment of Frontotemp...

                            Details : PR006 is an investigational AAV9 gene therapy delivering the GRN gene and is being developed as a potential therapy for patients with frontotemporal dementia with GRN mutations.

                            Product Name : PR006

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            November 30, 2020

                            Lead Product(s) : PR006,Methylprednisolone

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Prevail Therapeutics

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                            Lead Product(s) : PR001,Methylprednisolone

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevail Therapeutics Granted Composition of Matter Patent for Experimental Gene Therapy Program PR001

                            Details : The Company expects to initiate enrollment of the Phase 1/2 PROVIDE clinical trial of PR001 for Type 2 Gaucher disease patients in the fourth quarter of 2020 and currently anticipates it will provide the next update on PR001 biomarker and safety data for...

                            Product Name : PR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            November 18, 2020

                            Lead Product(s) : PR001,Methylprednisolone

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Lead Product(s) : PR001,Methylprednisolone

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevail Therapeutics Receives U.S. FDA Fast Track Designation for PR001 for the Treatment of Neuronopathic Gau...

                            Details : The Company is developing PR001 for patients with Parkinson’s disease with GBA1 mutations (PD-GBA) and neuronopathic Gaucher disease (nGD). Prevail expects to start enrollment of the PROVIDE Phase 1/2 clinical trial of PR001 in the second half of 2020.

                            Product Name : PR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            October 27, 2020

                            Lead Product(s) : PR001,Methylprednisolone

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Prevail Therapeutics

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                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Lead Product(s) : PR001

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevail Therapeutics Provides PR001 Program Update

                            Details : Company Advancing its Phase 1/2 Clinical Trial for the Treatment of Neuronopathic Gaucher Disease and Expects to Initiate Patient Dosing in First Half of 2020.

                            Product Name : PR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            September 01, 2020

                            Lead Product(s) : PR001

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Lead Product(s) : PR006

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevail Therapeutics Granted Composition of Matter Patent for Experimental Gene Therapy Program PR006

                            Details : PR006 is being developed as a potential one-time gene therapy for FTD-GRN, a progressive neurodegenerative disease caused by mutations in the GRN gene that reduce production of progranulin.

                            Product Name : PR006

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            July 27, 2020

                            Lead Product(s) : PR006

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Prevail Therapeutics

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                            Lead Product(s) : PR001

                            Therapeutic Area : Genetic Disease

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevail Therapeutics to Highlight Multiple CNS-Focused Gene Therapy Programs at 2020 American Society of Gene ...

                            Details : Preclinical data demonstrate potential of Prevail’s AAV gene therapy approach to slow or halt progression in multiple neurodegenerative diseases.

                            Product Name : PR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 29, 2020

                            Lead Product(s) : PR001

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Prevail Therapeutics

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                            Peptide Therapy Summit
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                            Lead Product(s) : PR001

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prevail Therapeutics to Present at AAT-AD/PD Focus Meeting 2020: Advances in Alzheimer’s and Parkinson’s T...

                            Details : The presentation will highlight preclinical data related to PR001 for PD-GBA and the design of PROPEL, Phase 1/2 clinical trial to evaluate the safety and efficacy of PR001 in patients with PD-GBA.

                            Product Name : PR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 31, 2020

                            Lead Product(s) : PR001

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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