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    [{"orgOrder":0,"company":"Prometheus Biosciences","sponsor":"Dr. Falk Pharma","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Collaboration","leadProduct":"PR600","moa":"","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"Prometheus Biosciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"","sponsorNew":"Prometheus Biosciences \/ Dr. Falk Pharma","highestDevelopmentStatusID":"4","companyTruncated":"Prometheus Biosciences \/ Dr. Falk Pharma"},{"orgOrder":0,"company":"Prometheus Biosciences","sponsor":"Eventide Asset Management","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Financing","leadProduct":"PRA023","moa":"","graph1":"Gastroenterology","graph2":"IND Enabling","graph3":"Prometheus 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Inc.","highestDevelopmentStatusID":"8","companyTruncated":"Prometheus Biosciences \/ Merck & Co. Inc."}]

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                            01

                            Prometheus Biosciences

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Merck & Co

                            Deal Size : $10,800.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Merck Strengthens Immunology Pipeline with Acquisition of Prometheus Biosciences, Inc.

                            Details : The acquisition will strengthen Merck's immunology pipeline by adding diversity of portfolio including, PRA023 (tulisokibart), a humanized monoclonal antibody directed to tumor necrosis factor-like ligand 1A, a target associated with both intestinal infl...

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : $10,800.0 million

                            April 16, 2023

                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Merck & Co

                            Deal Size : $10,800.0 million

                            Deal Type : Acquisition

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                            02

                            Prometheus Biosciences

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Prometheus Biosciences Announces Two Oral Presentations on PRA023 at the 18th Congress of European Crohn’s a...

                            Details : PRA023 is a humanized IgG1 mAb that has been shown to block the tumor necrosis factor (TNF)-like ligand 1A (TL1A), a target associated with both intestinal inflammation and fibrosis. It is currently in phase 2a clinical trial for crohn's disease.

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            February 22, 2023

                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Goldman Sachs & Co.

                            Deal Size : $500.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Prometheus Biosciences, Inc. Announces Pricing of Public Upsized $500 Million Offering of Common Stock

                            Details : Prometheus intends to use the net proceeds from this offering, together with its existing cash, cash equivalents and short-term investments to fund the development of PRA023 (a monoclonal antibody against cytokine TL1A), PRA052 and its other research and...

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            December 08, 2022

                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Goldman Sachs & Co.

                            Deal Size : $500.0 million

                            Deal Type : Public Offering

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                            04

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Goldman Sachs & Co. LLC

                            Deal Size : $250.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Prometheus Biosciences, Inc. Announces Proposed Public Offering of Common Stock

                            Details : Prometheus intends to use the net proceeds from this offering, together with its existing cash, cash equivalents and short-term investments to fund the development of PRA023, PRA052 and its other research and development programs.

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            December 07, 2022

                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Goldman Sachs & Co. LLC

                            Deal Size : $250.0 million

                            Deal Type : Public Offering

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                            05

                            Prometheus Biosciences

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Prometheus Biosciences Announces Positive Results for PRA023 in Both ARTEMIS-UC Phase 2 and APOLLO-CD Phase 2a...

                            Details : PRA023 binds both soluble and membrane-associated human TL1A with high affinity and specificity and has the potential to substantially improve outcomes for moderate-to-severe IBD patients predisposed to increased TL1A expression.

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 07, 2022

                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : PRA052

                            Therapeutic Area : Gastroenterology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Prometheus Biosciences Receives FDA Clearance of IND Application for its Second Precision Program, PRA052

                            Details : PRA052 is a monoclonal antibody blocking CD30 ligand that has a pleiotropic effect on both innate and adaptive immunity and targets a pathway that is distinct from TNF.

                            Brand Name : PRA052

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 03, 2022

                            Lead Product(s) : PRA052

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Prometheus Biosciences

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Prometheus Biosciences Completes Enrollment of the ARTEMIS-UC Cohort 1 Phase 2 Study in Ulcerative Colitis

                            Details : PRA023, is a monoclonal antibody against cytokine TL1A, a target associated with both intestinal inflammation and fibrosis,for the treatment of Ulcerative Colitis.

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            July 18, 2022

                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Prometheus Biosciences

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Prometheus Biosciences Provides Enrollment Update in APOLLO-CD and ARTEMIS-UC Global Phase 2 Studies

                            Details : PRA023 is an IgG1 humanized mAB block TNF-like ligand 1A, binds both soluble and membrane-associated human TL1A with high affinity and specificity and has potential to substantially improve outcomes for IBD patients predisposed to increased TL1A expressi...

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 08, 2022

                            Lead Product(s) : PRA023

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Prometheus Biosciences

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Prometheus Biosciences Initiates Third Phase 2 Study of PRA023 for Systemic Sclerosis-Associated Interstitial ...

                            Details : PRA023 is an IgG1 humanized monoclonal antibody (mAb) that has been shown to block tumor necrosis factor like ligand 1A (TL1A), binds both soluble and membrane-associated human TL1A with high affinity and specificity and has the potential to improve outc...

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 30, 2022

                            Lead Product(s) : PRA023

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Prometheus Biosciences

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                            Lead Product(s) : PRA023

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Prometheus Biosciences Provides Corporate Updates at the 40th Annual J.P. Morgan Healthcare Conference

                            Details : Based on positive topline Phase 1 results, US FDA has granted Fast Track Designation for PRA023, for the treatment of Systemic Sclerosis-Associated Interstitial Lung Disease to improve clinical outcomes for patients with this debilitating disease.

                            Brand Name : PRA023

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 12, 2022

                            Lead Product(s) : PRA023

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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