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    [{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"Chiesi Group","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"ISRAEL","productType":"Enzyme","year":"2023","type":"Inapplicable","leadProduct":"Pegunigalsidase Alpha","moa":"Alpha-galactosidase A","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Protalix BioTherapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Protalix BioTherapeutics \/ Chiesi Group","highestDevelopmentStatusID":"15","companyTruncated":"Protalix BioTherapeutics \/ Chiesi Group"},{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"Chiesi Group","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"ISRAEL","productType":"Enzyme","year":"2023","type":"Inapplicable","leadProduct":"Pegunigalsidase Alpha","moa":"Alpha-galactosidase A","graph1":"Genetic Disease","graph2":"Approved 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BioTherapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"ISRAEL","productType":"Enzyme","year":"2021","type":"Inapplicable","leadProduct":"Pegunigalsidase Alpha","moa":"Alpha-galactosidase A","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Protalix BioTherapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Protalix BioTherapeutics \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Protalix BioTherapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"ISRAEL","productType":"Enzyme","year":"2020","type":"Inapplicable","leadProduct":"Pegunigalsidase Alpha","moa":"Alpha-galactosidase A","graph1":"Genetic 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BioTherapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"ISRAEL","productType":"Enzyme","year":"2020","type":"Inapplicable","leadProduct":"Pegunigalsidase Alpha","moa":"Alpha-galactosidase A","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Protalix BioTherapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Protalix BioTherapeutics \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Protalix BioTherapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"Psagot Investment House","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"ISRAEL","productType":"Enzyme","year":"2020","type":"Financing","leadProduct":"Pegunigalsidase Alpha","moa":"Alpha-galactosidase 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Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Protalix BioTherapeutics \/ Inapplicable"}]

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                            01

                            Protalix BioTherapeutics

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                            AACR Annual meeting
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                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chiesi Global Rare Diseases and Protalix BioTherapeutics Announce FDA Approval of ELFABRIO® (pegunigalsidase ...

                            Details : Elfabrio (pegunigalsidase alfa-iwxj) is a PEGylated enzyme replacement therapy (ERT) for the treatment of adult patients with Fabry disease. It is a recombinant human α–Galactosidase–A enzyme expressed in plant-cell culture that is designed to provi...

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            October 05, 2023

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Protalix BioTherapeutics

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                            AACR Annual meeting
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                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chiesi Global Rare Diseases and Protalix BioTherapeutics Announce European Commission Authorization of PRX-102...

                            Details : PRX-102 (pegunigalsidase alfa), EC authorized, is a novel PEGylated, covalently crosslinked form of α-galactosidase-A developed as enzyme replacement therapy for fabry disease, was designed to increase plasma half-life and reduce immunogenicity, thereby...

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            May 05, 2023

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
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                            Protalix BioTherapeutics

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                            AACR Annual meeting
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                            Lead Product(s) : PRX-115

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics Announces First Patient Dosed in First in Human Phase I Clinical Trial of PRX-115 for...

                            Details : PRX-115 is a PEGylated enzyme expressed via ProCellEx® for intravenous (IV) administration of recombinant Uricase, designed for safe and efficacious treatment of refractory gout

                            Product Name : PRX-115

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            March 21, 2023

                            Lead Product(s) : PRX-115

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
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                            Protalix BioTherapeutics

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                            AACR Annual meeting
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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics and Chiesi Global Rare Diseases Announce Resubmission of Biologics License Applicatio...

                            Details : PRX–102 (pegunigalsidase alfa) is an investigational, plant cell culture-expressed, and chemically modified stabilized version of the recombinant α–Galactosidase–A enzyme.

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            November 14, 2022

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
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                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics and Chiesi Global Rare Diseases Announce U.S. Food and Drug Administration Acceptance...

                            Details : PRX–102 (pegunigalsidase alfa) is an investigational, plant cell culture-expressed, and chemically modified stabilized version of the recombinant α–Galactosidase–A enzyme. It is a novel, PEGylated ERT under development for the treatment of Fabry d...

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            May 12, 2022

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
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                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix Biotherapeutics and Chiesi Global Rare Diseases Provide Regulatory Update on PRX-102 for the Treatmen...

                            Details : Pegunigalsidase alfa (PRX–102) is an investigational, plant cell culture-expressed, and chemically modified stabilized version of the recombinant α–Galactosidase–A enzyme. Protein sub-units are covalently bound via chemical cross-linking using sho...

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            November 10, 2021

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
                            Not Confirmed

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
                            Not Confirmed
                            • fda
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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics and Chiesi Global Rare Diseases Present Key Clinical Data of Pegunigalsidase Alfa for...

                            Details : Following the switch to pegunigalsidase alfa there was a decrease in patients with progressing or fast progressing kidney disease, and the majority of patients achieved a stable status post-switch.

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            October 02, 2021

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
                            Not Confirmed

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix and Chiesi Global Rare Diseases Provide Update Regarding Clinical Development of PRX-102 for Fabry Di...

                            Details : PRX–102 is currently being studied in the pivotal Phase III BALANCE clinical trial and in two ongoing long-term extension studies, all of which are part of the overall clinical development of PRX–102 for the proposed treatment of Fabry disease.

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            February 06, 2021

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
                            Not Confirmed

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Psagot Investment House

                            Deal Size : $43.7 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics Announces $43.7 Million in Financing

                            Details : Financing will advance the Company's clinical programs and commercialization of PRX-102 for the treatment of Fabry disease, as well as to further develop its early stage pipeline of therapeutics.

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Undisclosed

                            December 03, 2020

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Psagot Investment House

                            Deal Size : $43.7 million

                            Deal Type : Financing

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                            10

                            Protalix BioTherapeutics

                            Israel arrow
                            AACR Annual meeting
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                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics and Chiesi Global Rare Diseases Announce U.S. FDA Acceptance of BLA for Pegunigalsida...

                            Details : U.S. Food and Drug Administration (FDA) has accepted the Biologics License Application (BLA) and granted Priority Review designation for pegunigalsidase alfa for the proposed treatment of adult patients with Fabry disease.

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            November 08, 2020

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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